Basic Information

Gene Symbol
Mbd2
Assembly
GCA_030704555.1
Location
CM060812.1:4186203-4189274[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 9.1e-28 2.2e-24 85.4 0.1 1 72 5 71 5 76 0.93
2 2 0.00074 1.8 8.8 0.0 29 74 93 146 77 149 0.87

Sequence Information

Coding Sequence
atgaatatctCTATAGAAAAGAAAAGATCGGATTGTTCTGCATTGCCAAAAGGTTGGCAAAGAgaagaaataataagaaaatctgGATTGTCTGCAGGCAAAGTTGATGTTTATTACTATAGCCCAACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTAGTGCGTTATCTTGGTGATAGTGTGGACTTGTCGTGTTTTGACTATCAACAAGGTCAAATTAACACAATGCTCCTGTGCAAGGCCAAGAAAGCTCGAGCTCAATTTGATTACAGGGGTGTTCGTTCAGACACTTCACTTGTGCCCCCAATACGTCAAACTGCCTCTATATTTAAGCAACCAGTCACTGTTTACAAGACTCaagaaagtaaagtaaaaactgACCTCAAACAAGGCACACAAGAAAAGCCGAAACAGCTATTTTGGGAAAAACGTCTAGAAGGATTGACCGCTTGTGATTCTAATGGAGTAGTTGGTACAACATCTCTACCAAAATACATTAAACCTCTGGGACCATATACTTCAGACGCTACAACAATACAGTCCTTAGCTACAGCTTTACATGTTTCATCCCAACCCATAACAGGTCAAACCGGatcaaaacaaacaataatagaGAGCCCGGGAGTTTTTTTAAACCCGGACCAGCCATTGATAGCTGCGGTGACCATAACAAAGGATGACCTGCGTCGGCAAGAGGAGCGTGTGAAGCGCGCGCGTTTGAGGCTCCATGAGGCCCTAGCGGCTGCATAG
Protein Sequence
MNISIEKKRSDCSALPKGWQREEIIRKSGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSVDLSCFDYQQGQINTMLLCKAKKARAQFDYRGVRSDTSLVPPIRQTASIFKQPVTVYKTQESKVKTDLKQGTQEKPKQLFWEKRLEGLTACDSNGVVGTTSLPKYIKPLGPYTSDATTIQSLATALHVSSQPITGQTGSKQTIIESPGVFLNPDQPLIAAVTITKDDLRRQEERVKRARLRLHEALAAA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090793;
90% Identity
iTF_00774506;