Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.2e-91 1.1e-86 292.3 24.3 44 299 8 260 2 261 0.96

2 3 0.0077 3.7e+02 1.6 3.8 123 171 262 310 260 313 0.89

3 3 0.046 2.2e+03 -1.0 6.9 193 237 291 334 272 336 0.56

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.2e-91	1.1e-86	292.3	24.3	44	299	8	260	2	261	0.96
2	3	0.0077	3.7e+02	1.6	3.8	123	171	262	310	260	313	0.89
3	3	0.046	2.2e+03	-1.0	6.9	193	237	291	334	272	336	0.56

Coding Sequence: ATGATTGTAGGCGATGTAAATAGAACTATGAGAGTAACTCCAGATCCAGTGCGTGCATCACGACTTCTTACAAATTCCAACAATTTTCAATCAAGTCGTAGATCTTCAGAAGATTCATTGGAAGACGCAGGATTAAACAGAGATATTAGGctgGAATTAAAGGAATTTGAAGAAAAATTCAGGAAGGCAATGATAGCTAATGCTCAGCTAGACAATGAAAAATCATCATATGCCTATCAAGTTGACTTATTAAAGGATAAATTGGAAGAATTAGAAGAAACCACTGCGCAATTACGTAGAGAATTGAGAGAGAAAAATCGAGATGTTGAGCAGTTAAAACGGGTCAGTCAAAGACTGAAAGAAGATTTAGATATTTGTAAAGCGCAGTTACTAGAAAGAGATACACTTATACAAgaAAACGGTTTAGTCATTGTTGACAATAAGGAAAGTGAAGATGAGGATAACGAAAATATTGAAAATGGATTATACCATAGAAAGAGGATACTAATCAGTACAGAAGCTGCAGAATTATTAGAAACGGCTGGTAAAGGTTCATTAGatattcgATTGAGAAAGTTTGCTTCGGAGAAAAAGGAATTGCAAGATGAAATTCGCCGTTTAAGATCGGAATTAGAAGAAACTAGGAATCGCGTGAGACCCGAAAAATCATCTGGCTCAATATTAGGTTGTTTAACAGATAACGAAGATATTCAACGTGAAGCGAATAAATTATTGGctgattataaatttaaattacaaaaaacgGAGCAAGATATGTCAATGCTGCAAGCAACAGTAGCTAGATTAGAAAGTCAAGTAATTCGTTATAAATCAGCTGCGGAAGCATCTGAAAAAGCAGAAGATGAATTGAAAGTAGAAAAAAGAAAGTTGCAAAGAGAAGTAAGAGAAACACAAAGTCGTGTAGAGGAATTAGAAACAGCAAACTCTCATCTACAAAGGAGGTTGGATAAACTTAAAAACGCTAAATCAGCTCTTTTAAAAGAACTTTGA
Protein Sequence: MIVGDVNRTMRVTPDPVRASRLLTNSNNFQSSRRSSEDSLEDAGLNRDIRLELKEFEEKFRKAMIANAQLDNEKSSYAYQVDLLKDKLEELEETTAQLRRELREKNRDVEQLKRVSQRLKEDLDICKAQLLERDTLIQENGLVIVDNKESEDEDNENIENGLYHRKRILISTEAAELLETAGKGSLDIRLRKFASEKKELQDEIRRLRSELEETRNRVRPEKSSGSILGCLTDNEDIQREANKLLADYKFKLQKTEQDMSMLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRETQSRVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2