Basic Information

Gene Symbol
Mbd2
Assembly
GCA_956483585.1
Location
OY101442.1:13732646-13734598[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.4e-26 5.3e-22 78.4 0.0 1 73 9 76 9 80 0.95
2 2 2.2e-05 0.18 12.6 0.0 27 74 200 256 185 259 0.87

Sequence Information

Coding Sequence
atgcaAATGAACTCGAATATTTCAATTGAACGTAAGAAAGTAGACTGTAATTCCCTTCCAAAAGGATGGCAAAGAGAGGAAGTTTTACGAAAGTCTGGAATCTCAGCGGGAAAAGTTGATGTCTACTATTAcagTCCAACTGGAAAACGTATAGATAGCAAACCACAATTGGCACGTCATTTAGGAGAAGCTATAGATATAAGCAGTTTTGATTTccaaaaaggcaaatttatacaacatctgCCATCACCTTCTATATCACTGTACCGCTGCATATCCGCGACGACGCCTGCAGTCAGCAGTAGTGGAACTGGCTTAGGAGGTGGTGGTAGCAATACTGGCATTAGTATTGCTGGTAATGCTACTTCATTGCCAACATTGGGTGGTGGCATTACTATAATGCCATCACATCATGCATCTGCGGGCCACAATTTAAAGCGTAAACATAGAATGGGATCTCAAACAGCAGTTTTTAATTTGCCTTCGTTGTCTTCCACTTCAATTTCGAATCATCATAATCTTTTAAGTTCTTGCACAACGATGACGACGATGACATCAACAAATTTGCCACTTAAGCAGCAACAATTAGAATTCAGtcGCGCTATGCGAACAGATGTCTCAATGGTGCCGCCTATACGCCAGACTGCTTCTATATTTAAGCAGCCCGTAACTGTAATACGAAATCATGAAAACAGCAAGACAAAAAATGACACAAAACAAGGAGCACAAGATAAACCGAAGCAATTATTTTGGGAAAAACGTTTAGAGCGTATACGAGCTTGTCATGCAACCGGTGAGCAATTTGATGACATTGTATTGCCCAAGAGTCTTAAACCTTTAGGGCCTAATGTCCATGAACAGACCGTCATGCAATCACTAGCTACAGCTTTACATGTACTCAATACTCCTGTAACTGGACAAACAGCTTCTAAAACTGAATTTCAAAAAAACGCCACGGCTTTCATCAATCCTGACCAACCCCTGATGCAAGGTATACTCATATCAGATGATGATATACGGCGACAAGAAGATCGTGTTAATTCGGCAAGAAGAAAGCTACAAGAAGCTTTAAAAGCTTAA
Protein Sequence
MQMNSNISIERKKVDCNSLPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARHLGEAIDISSFDFQKGKFIQHLPSPSISLYRCISATTPAVSSSGTGLGGGGSNTGISIAGNATSLPTLGGGITIMPSHHASAGHNLKRKHRMGSQTAVFNLPSLSSTSISNHHNLLSSCTTMTTMTSTNLPLKQQQLEFSRAMRTDVSMVPPIRQTASIFKQPVTVIRNHENSKTKNDTKQGAQDKPKQLFWEKRLERIRACHATGEQFDDIVLPKSLKPLGPNVHEQTVMQSLATALHVLNTPVTGQTASKTEFQKNATAFINPDQPLMQGILISDDDIRRQEDRVNSARRKLQEALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01109335;
90% Identity
iTF_01397429;
80% Identity
-