Gfla026542.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Gortyna flavago
Gene Symbol
egg
Assembly
GCA_963669345.1
Location
OY770153.1:3288407-3328687[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.5 1.2e+04 -3.3 0.1 26 38 1915 1927 1892 1928 0.79
2 2 1.3e-12 4.7e-09 36.5 0.0 4 73 1959 2021 1956 2025 0.88

Sequence Information

Coding Sequence
ATGCCTGAAAATGTGCCTAAAGGGGCTGGAGATGATAAAGTACGTATTTTACTAGATAACTTAGAACTTGACAAAATAGAATCAGAGTTGTCAGAAATGTCAAAAGACATCATAAATACTGATGCAGGCAAAGATGCTGGTGACTATACAGATGAAGCAAAGGTCAGTGCAAtagatgataaaaaaattgaggaTGTTAACACTAAAATTGATGCAAAAGTATCTATAACCAATGTTACTGTTGAGAAAGATGAAAGCAATGATACTTCCCTCGACAAGTGTAATGAAAAGGAATCTAAAAAGGCAGATGATCTTGATGAAATTGAAGATGATGATATGGAACTAAGAtgggatgatgatgatgacgatagcAATCATCCTATGGGTGATGATAATGGAAACACAAACACTAAGAATGATGATATTCTGTCCAAAGGCCAACTTTTGGAAGATCCTTcagatgttttaaataaagatattacTGAAATGCCTTCTGATGGGAATCCTAAAGTTTCCGGAGCCAATCTTGATAGTGATGTGTTAAAAGTCAACAATGAAGAAAATAGTCTTACAAGAGATGATAATTCTATAGAAATTAAAACTACTAAAGAATCAGAAATTAGTCAAAAACTAGACATTCCTAAAGATGAAAAAATCTTGGTAGATATGCGTTTAGAGGAAAACGACTTAAATACTGAAGAAATAAATAGCCCAGAAATGGATTTTTCCGCAGAAGAAAGTATGGATCGAGATGATATTAACATCTTAGAAGAGAAACTATTGGAAGAATCTGAAAATACTGAAGAAATAAATAGCCCAGAAATGGATTTTTCCGCAGAAGAATCTATGGATCGAGATGATATTAATGTCTTAGAAGAGAAACTATTGGAAGAATCTGAAATTGTCACTGAAGCAACAGTAATAGCGCCGGAAAAAGAGATTCTAGAAGAGAAAAGTATGGATGAACTAATAAAAGAGACAGAATCTGCTAAAACCAATCTTCTAACGGAAGTTACTAATGATGAACAGACAAAAGAAGATCCAGTTGCCACAATTGAAGAAGAACAACTTTTAGCTGAATCTACAAGTAACACTGAAACTGAGTCTTCAACATTGAAGttgaaatcttttaaaaatgtcatcttgaacaaaaataatgatgatattATGTCAGAAGAAAAGCTTTTAGAAGAACCTGATTCTAAGTGCGAAAGttctttgtttatttctgaCAAAGTTATTGAATATTCTAAAATAGTTCCTGAAAAAGAGGCCACAATTAATAAAGAAGATAATGATGATGCTCTGCTAGAAGAAAAACTATTACAAGAAACGGAAACATCTGAAATTATTCCTGAAAGTGATAAAACAATGGATGTTGATAATGAAGAAGAAAGAGAATTACTGAAAGATGATGAACTTCTAGAAGATAGCTGTACTCCTATGGATGTGGACGATACTGACATATCTATTGGAGATCAGGCTAAGGTAGAAGACAAGATTATAGATCAAACAATGAATCAATCTGAAGTAGCAAAGAAAGGTCTAGCTCTGCCAATAGAAGACCAAACTAATATAGAAAAGGTAGATGAAACAACAGATGAAGTTAAAAATATGGATCAATCTGATGATCAAAGCAGAATAATTGAGAAAGTTATTGATCAGCCAATCAAAGATACATCTAAAGCAGTAGATATTGTTAAAGATACACCTATTGAAGATGAAGTTAAAAAACATGAGGAAATTGTAGATCAAGCTGTCTCTGAAAAAGAGAGAATTGATCAACAAATTGATGATGAAACTAAAATGGAAGACAGCAATAGAGATCAATTAATTCATGAATCTAATACAGAACAGTCTATTAAGAGTCCTGTACAAACAGATGCAATCTCTGTTTCTAATACTCCTAACATTCTAGTTGAAGATCTAGAGAAACCTATCCCGGAAGAAGCTACTCTTGTAGAAGAAATTAAAACAGATCCAAAAGAACTTAAGGAAAATACTGAAAGTTTATACAAAGACACAGATTTAGACAAACctgaaaaaagtaaagaaattaTCAATCCAGACACTAGCTTAGATAACAACAAGGAGGTTGATGAAATTTCATTTTCTAACAACTCTTCAATATTTCTAGAAGTTTCGTGTCCTATCAAAACTGACCATGGAGTGCATAAACCAGACGTAATGTTAGAAATACCTACACAAGAACTAATTGACATGGATGATACAGATTTTTCTATGAATTTAGACCATTCTGTAATGATTGACAGTCTTAATGATGTTGACAAAAACGTTGATGATGATATAGTACATGACAAAACAATTGATGAAACTGTTGTTGATGATGTCATAGGAAGTGATAAAATTGTTACTGATAATGCTACAGTCAGTGGGAAATCAGTAGAACAAGCTAAAGTAGATGAAGATACAGTAAAAGAGAAACCAGTAGATCAAAAAGCCTTAGTTACTGAATCAACAATTATTGATAACATCATAGCTGAAGATGACGCAGAGAAACCAGTAGATCAAAAAGCCATAGATACTGAAATGACAACTGTTGATAAAATCATTGCTGATGAAGACACAGGAAAAGAGAAATTAGTAGTTCAAGAAGCCATAGTAACTGAATCAACAGTAGGTGAAGTCCAAACAGTAAGTAATATTGCGGAAAGTGACAAGAAAGTTGAAGATACTGTTGTTCAAGCAACAGAAATAGCAACTGTTGAAGAAAACATGGAAAGAATGTTTGCAGATGAAGAGTCAGAAGTTGCTAAAGAAATTGCAGAATGCATTGCATCCACAAGCCAAGTTCAAGTACCCGCCGAGCAGCCATCAGCATCCATAACCCGTATGACTCCAGACACATCAGATGAAGTTCCAGAGATAGATGACAGTCTGGGTCTGTTGGCTGAGTCTGCAGGACGGATGATGGAAGATGATGAGGAGCctgatgatgattttgatggtgacgatgatgatgattttgatcATGATGAAAGCAGTAACCAAATCTCGGCAGAACAGTCGGAGGATTCGAACCCAGCAGCATTAGAATCTGAACTAGCAAGAGACCAGGAAGACAAGGAGTTGGAGACTCCAGACCCTAAGGATGAAGAGTTCATGATGTGTGACAGTACATCCCAGGATAAGGCGGAGAAGATGGACGTGGAAGAGGAATATGGCACAgtGCAGTTACAGGCGGAAACAATAAATGAAATGCATGAAGAGGCAAAGTCGGCTGTTGATGCGTTGTTGAACGTTGATAACCCCGCCAGTGAACAAGTTCAGGATCAACAAGAAACCACAGACCAAATGGACATAGAGACTGTGAAGCTGTCAGATACGTCTGACAACGAAGTTGATGTTGAACCTACGGAAGTTCAACAGGCTGTGGCTAAATCAAGTGGGGAGGATGAAGAAAAACAAAAGCCCTCGCCTTCTAAATCACCGAGCAAGAGCAATATATCGCCCAAGCAATCGCCAAGCAAGTCGAGCCAGCCGCCCTGTAAGCAATCCCCGAGCAAGATGAAGAATTTGACTATCACCACGCAAGCACGTAACTCCGTTGTCAATATTGTGGATTTAGAGGAGAGCAGTTCTTCCGAAGATGATATTCAAGAAGTACAAAAACAACAGGAGCCAGAAACAACACAGGATGACACACCTTCCCCGGAATCAGATGTTACCAACGTTAATATACCAACGGGCATAGACATAATGTGCACTTCCGGCGGAAATACGTCAGAGATAACGACTAAAGACAACCTCTCCCAGGTTGTTATCAGTGGCGTGCCTAAGCCGCCGCCGCATAAGCCTgcTAGATTGAATACCAGTGAAGTTTCAATCAAAACTGTTAGTAATACAGAACCATTGATTATACCTGAAACTAAGATTAATGAACAGACGCAAGAACAGTCTAAACCTAAACTAAGTCTAGAAATATTCAGTCTAGATTCTGATGACGATGAAAACGCTGCTAAAGaaaaaccACCACTAACACCCTCACCTCACAAAATGACGGCCTTAGAATTAGAAAAAGCTCGAGAAACATCCAAATGTATCAACTATTGTTGCACAAGCGACAACAAAGTGCCTTACAAGGTGGCGGAGGCGTCAGTGGTCGCGTACTACGACGCGGGCAGGAAGAGACGCTCCATGGTGTGCCAGCCATGCGCCGATGTGGTCGCTGCTAGGACTAAGAATCTAATTCAAGGCATAAAGGATCTAACTCCACTATTAGACTTGAACATGGGCAAGTTATCACAAGACTTGGTGGAGATATCCGACTCGGAGTCTGAAGATGAGGTTATGAGTAATGAGGAACCCAAGGAGAGTATCGGAGAGAAAGGGGCTAAATTCATAGAAGAAAATCTGGCCAAGTATTTGAACGACACGTGGAAGAAATACGACATGGACGTGCGTCTCACAGAAACACAGATTATGTTAGATGATGAGATTGAAAAACTTGAACAGGACAGCAAAGAAATCGACGCAATGCTAAACGAGTGTCAGGTAGCGACAGACAAGCTTCGCTGCGAGTTATATGCAACGTTCGAGTGTCGACGACAAAAACTACCCTCCTTAACTATATACGACACGCCTGAGTCTAAaACTCGTCAAGCCAAGCGTCGTTTGTCTTCAACCAGTGAGACTCCAGCCAAACGTCCCGCTATACCGCTTGGATATGCACCTTTAGATGGCGCTGATTCCAAGGAAAAAGCTGCAATCCCGGCGCCAGATAATAAACAAGATGATGACAAAGACATATCAGTAGTGAAACTGTCAGCGGAAGCCGCCCCGGCAGAGCTGCCCCCCCCCGGCGAGATCTCGCGCCCGCCGCTGCGCGTGGGCATGCCGGTCTATGCCATGAAGAACGCCTTCGGACCCTGGCTTAAAGGCAGAGTGGTGGAGATACAGCCCAAGAACACGTCTGGGGGCAACCCATTCTCTGTGTGTCTTGTGAAGTTTGACCACAAAGTCAAGACTAATGGGAAAGTGTTGCATGCAAGGTGCATCGCATATTCTGAGCCCGCTGATGTTAGAATGACTATTGGTACCCGTCTTATAGCGCTGTTCAAGGATTCGAACAAACGCGAATCGTACTACTCAGGAGTTGTAGCTGAAATACCCAATCCAGTCAATAATTATAGATATTTAGTATTCTTCGACGATGGTTACGCTCAGTACGTCCAGCACCAATTCACCCGCCTAGTCTGCGAAAGTTCCCCTTTAGTATGGGAGGAAGTACATCCATTCTCCCGGGAATTCGTCCGTCAGTACCTAATGGAGTATCCGGAGAGACCCATGGTCAGGCTGCATGAGGGGCAGCATCTGAAGACTGAGTGGAACGGAAAATGGTGGTCATCCCGAGTGACCCGCGTGGACGCGTCGCTGGCGCAAGTGATGTTCGTGGGCGACGGCCGGCGCGAGTGGATCTACCGCGGATCCACGCGCCTCGCGCCGCTCTACCTCGAGCTGCGCGCGGCTGAACGACACCGACCTAGACCCATGCCGCGGAGCAAGGCGCAGCCTAGGTTCAATATGCCGTACGTGGAGTACACTCGGTCGGATGAGCAGGAGTCGAACAAGCAAGTGGATGCGCAGGCGCAGCAACAGCAAgaacagcagcagcagcagatACAAAATGAGGAGATACGCCGCCAACGCGCCGTGGCCAAGAAGTCTACGTCAGCTCCTCCTCAAGTGCTCCCGCCATCACAACAGGTTATGCCCTCAACATCGGATACAGTCACAAGCAGAGTTGTGTACTACACACCAAAGAACGCGGTGAAACCATTGAAGATGGTGCCACACAGGTGTGGGCCGAAATGCAAGAGAAGCGACGTACTCTCACTAAAAGAGTTGAGGACTTATAATCCTCTAGCTAAACCACTGCTCAGCGGATGGGAAAGACAAATTGTCCGCTTCAAGGGCCACAAGGAAGTGATGTACCGAGCGCCCTGTGGCCGTCGCTTACGAAACATGCGCGAGTTACATCATTACTTACGTTCTATAGACAGCGACTTGCCTGTGGATCTGTTCGACTTCCACTATTCAACGCATTGTCTGGCAGAATTCGTGCTGAACAAATGTCTCGTGGGGAAAAAGGACCTCTCCCACGGCAAAGAGAACGTCCCAGTGCCCTGCGTGAACTACTACGACGACTCGTTACCGGAGTTCTGTTCTTACAACACCGAGCGCACTCCCACCGCCGGCGTGCCGCTCAACCTGGAGCCCGAGTTCCTGTGCGGCTGCGACTGTACCGACGACTGCCAGGATAAATCAAAATGCGCTTGTTGGAAAATGACGCTAGAGGGCGCTCGCACCATCGGGCTACGCGGACCTAATTTGGGCTATGTGTACAAGCGATTGCCTGAACCGTTACCTTCTGGCATATACGAGTGTAATTCTAGGTGTAAATGCAAGCACACATGTCTAAACCGCGTGGCGCAACATCCACTACAATTAAAATTACAGgTGTTCAAAACTCCAAACCGTGGTTGGGGCATTCGGGCACTGAACGACGTGCCAAAAGGCTCGTTCCTATGCGTGTACGCCGGTAACCTACTGACTGACGCTACAGCTAACTTGgACGGTTTGAACGAGGGCGACGAATATTTAGCAGAATTAGATTATATAGAAGTTGTGGAACAGATGAAGGAGGGTTATGAAGAGGACATTCCGGAGGCCGACAAGAAATTAGACAAGAAAGAAGTTAAAGATGGTGATGACAGTGACGAGGATGACCCGTCATCCTCCGAGGATGAGGAGACGGCCGATAAGACTGACAAGGAAGATGATGACTTCAGACCTGGATACATTGGACTTGGCGTTACGGAGTTCAGCAAACGCCTCCGTAAACGCGAAAAATCAAAGAAAGATAAAGAAAACGTGGCAGGTGATGAGAAAGAAAAGGACAAAGATACGACGAAAGAGTCGAATGCTGAAGAGGATTGTATTACTATAAGTGATGATGAAGAAGTACGAGAACCTTCAAGATTCATGGCGCAAACGAACATGGGCGCTAGCGAATATATTTCTAAATACAAGTCTGTTCGCACGTTATTTGGTAAGGACGAGGCGTGCTATATCATGGACGCTAAGGTTCAAGGCAACATTGGCAGATATCTCAACCACTCTTGTTGCCCGAATGTCTTCGTACAGAACGTGTTTGTGGACACCCACGACCCTCGCTTCCCATGGGTGGCGTTTTTCGCGCTCTCGCACATCAAAGCAGGCACCGAGCTCACTTGGAACTACAACTATGACGTGGGTTCGGTTCCCGGGAAGATACTTTATTGTTATTGTGGAGCTCCTAACTGTAGGGGAAGACTGTTGTAA
Protein Sequence
MPENVPKGAGDDKVRILLDNLELDKIESELSEMSKDIINTDAGKDAGDYTDEAKVSAIDDKKIEDVNTKIDAKVSITNVTVEKDESNDTSLDKCNEKESKKADDLDEIEDDDMELRWDDDDDDSNHPMGDDNGNTNTKNDDILSKGQLLEDPSDVLNKDITEMPSDGNPKVSGANLDSDVLKVNNEENSLTRDDNSIEIKTTKESEISQKLDIPKDEKILVDMRLEENDLNTEEINSPEMDFSAEESMDRDDINILEEKLLEESENTEEINSPEMDFSAEESMDRDDINVLEEKLLEESEIVTEATVIAPEKEILEEKSMDELIKETESAKTNLLTEVTNDEQTKEDPVATIEEEQLLAESTSNTETESSTLKLKSFKNVILNKNNDDIMSEEKLLEEPDSKCESSLFISDKVIEYSKIVPEKEATINKEDNDDALLEEKLLQETETSEIIPESDKTMDVDNEEERELLKDDELLEDSCTPMDVDDTDISIGDQAKVEDKIIDQTMNQSEVAKKGLALPIEDQTNIEKVDETTDEVKNMDQSDDQSRIIEKVIDQPIKDTSKAVDIVKDTPIEDEVKKHEEIVDQAVSEKERIDQQIDDETKMEDSNRDQLIHESNTEQSIKSPVQTDAISVSNTPNILVEDLEKPIPEEATLVEEIKTDPKELKENTESLYKDTDLDKPEKSKEIINPDTSLDNNKEVDEISFSNNSSIFLEVSCPIKTDHGVHKPDVMLEIPTQELIDMDDTDFSMNLDHSVMIDSLNDVDKNVDDDIVHDKTIDETVVDDVIGSDKIVTDNATVSGKSVEQAKVDEDTVKEKPVDQKALVTESTIIDNIIAEDDAEKPVDQKAIDTEMTTVDKIIADEDTGKEKLVVQEAIVTESTVGEVQTVSNIAESDKKVEDTVVQATEIATVEENMERMFADEESEVAKEIAECIASTSQVQVPAEQPSASITRMTPDTSDEVPEIDDSLGLLAESAGRMMEDDEEPDDDFDGDDDDDFDHDESSNQISAEQSEDSNPAALESELARDQEDKELETPDPKDEEFMMCDSTSQDKAEKMDVEEEYGTVQLQAETINEMHEEAKSAVDALLNVDNPASEQVQDQQETTDQMDIETVKLSDTSDNEVDVEPTEVQQAVAKSSGEDEEKQKPSPSKSPSKSNISPKQSPSKSSQPPCKQSPSKMKNLTITTQARNSVVNIVDLEESSSSEDDIQEVQKQQEPETTQDDTPSPESDVTNVNIPTGIDIMCTSGGNTSEITTKDNLSQVVISGVPKPPPHKPARLNTSEVSIKTVSNTEPLIIPETKINEQTQEQSKPKLSLEIFSLDSDDDENAAKEKPPLTPSPHKMTALELEKARETSKCINYCCTSDNKVPYKVAEASVVAYYDAGRKRRSMVCQPCADVVAARTKNLIQGIKDLTPLLDLNMGKLSQDLVEISDSESEDEVMSNEEPKESIGEKGAKFIEENLAKYLNDTWKKYDMDVRLTETQIMLDDEIEKLEQDSKEIDAMLNECQVATDKLRCELYATFECRRQKLPSLTIYDTPESKTRQAKRRLSSTSETPAKRPAIPLGYAPLDGADSKEKAAIPAPDNKQDDDKDISVVKLSAEAAPAELPPPGEISRPPLRVGMPVYAMKNAFGPWLKGRVVEIQPKNTSGGNPFSVCLVKFDHKVKTNGKVLHARCIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQFTRLVCESSPLVWEEVHPFSREFVRQYLMEYPERPMVRLHEGQHLKTEWNGKWWSSRVTRVDASLAQVMFVGDGRREWIYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRFNMPYVEYTRSDEQESNKQVDAQAQQQQEQQQQQIQNEEIRRQRAVAKKSTSAPPQVLPPSQQVMPSTSDTVTSRVVYYTPKNAVKPLKMVPHRCGPKCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRFKGHKEVMYRAPCGRRLRNMRELHHYLRSIDSDLPVDLFDFHYSTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLRGPNLGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTPNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPEADKKLDKKEVKDGDDSDEDDPSSSEDEETADKTDKEDDDFRPGYIGLGVTEFSKRLRKREKSKKDKENVAGDEKEKDKDTTKESNAEEDCITISDDEEVREPSRFMAQTNMGASEYISKYKSVRTLFGKDEACYIMDAKVQGNIGRYLNHSCCPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKILYCYCGAPNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00037842;
90% Identity
iTF_01093126;
80% Identity
-