Basic Information

Gene Symbol
MBD2
Assembly
GCA_000688735.1
Location
Scaffold63:924972-928167[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.5e-25 1.2e-21 76.2 0.0 1 73 7 74 7 78 0.94
2 2 3.2e-05 0.16 11.7 0.0 26 75 179 237 168 239 0.90

Sequence Information

Coding Sequence
ATGAACTCGAATATTACTATTGAGCGAAAGAGAGTAGACTGTAATGCTTTACCAAAGGGCTGGCAAAGAGAGGAGGTATTAAGAAAATCAGGAATCTCAGCAGGAAAAGTTGACGTTTACTACTATAGTCCTACAGGTAAACGTATCGACACAAAACCCCAACTGTCACGCCACTTGGGAGATGCGATAGATATAAGCAGTTTCGATTTTCAAAAGGGCAAATTTATACATCACCTACCGCTGCCTTCCATATCCGTATATCGCTGCTCGGCTGTCAGTGGTACCGGTTGTGTTAATTCAAGCAGTACGACAACGTCTATAGGAGCTTCTGGAGGTCCTCTAACAATAACACCACAAGCTGCTAGCTCAAATTCTTTAAAACGGAAACATAAAACGGCAACGCAACCTCCAGCTGGAGCCTCGCCCCAACATAGCACTTTATTGGGGTCTTGTACTGTAACTGTTCCTACTGCAGCAGTGCCGGCAGCAGCCAGTAGCAACGTTAACATAAGACAGCAACAACAATTAGAATTCAGTCGAGCATTGCGCTCAGATGCTTCATTGGTTCCTCCGATACGTCAAACAGCCTCTATATTCAAACAACCGGTAACGGTGGTGCGAAATCACGAGAATAACAAAGTAAAACATGACACCAAGCATGGTGCTCAGGAAAAACCTAAGCAACTGTTTTGGGAGAAACGTTTAGAACGTATGCGAGCCTGTCACGCGAGCGGTGAGGAATTGGATGATATTGTTTTACCGAAAAATTTGAAAGCGTTAGGTCCTAATGTACATGAACAGACGGTTATGCAATCACTAGCCACAGCTTTGCATGTGCTAAATACGCCAGTAACTGGACAAACTGCCACGAAGTCTGAATTCCAAAAGAACGCCCCGGCTTTTATTAATCCTGACCAACCATTAATGCAGGCCATACTAGTCTCTGATGACGATATACGGCGACAAGAAGACCGTGTAAACATAGCCCGACGAAAACTACAAGAAGCCTTGAAGGTTTAA
Protein Sequence
MNSNITIERKRVDCNALPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIDTKPQLSRHLGDAIDISSFDFQKGKFIHHLPLPSISVYRCSAVSGTGCVNSSSTTTSIGASGGPLTITPQAASSNSLKRKHKTATQPPAGASPQHSTLLGSCTVTVPTAAVPAAASSNVNIRQQQQLEFSRALRSDASLVPPIRQTASIFKQPVTVVRNHENNKVKHDTKHGAQEKPKQLFWEKRLERMRACHASGEELDDIVLPKNLKALGPNVHEQTVMQSLATALHVLNTPVTGQTATKSEFQKNAPAFINPDQPLMQAILVSDDDIRRQEDRVNIARRKLQEALKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2