Basic Information

Gene Symbol
MBD2
Assembly
GCA_949710015.1
Location
OX453290.1:27392995-27394545[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.4e-25 1.6e-21 75.7 0.0 1 73 7 74 7 78 0.94
2 2 0.00014 0.49 10.0 0.0 26 75 169 227 158 229 0.84

Sequence Information

Coding Sequence
atgAACTCGAATATAACAATTGAACGCAAACGGGTGGACTGCAATGCATTGCCAAAAGGCTGGCAAAGGGAGGAGGTTTTAAGAAAGTCGGGTATATCGGCCGGTAAAGTGGATGTTTACTATTACAGCCCAGCGGGAAAGCGCATGGACAGTAAGCCACAGTTGGCTCGACATCTGGGTGATGCTATTGATATTAGCAgctttgattttcaaaaaggcAAATTCATACATCACCTGCCGCTGCCATCAATATCGCTGTACCGGTGTTCTGCTGCCTTTACAGGCGACACGAACAATTCCATAACAACTGCAGGCGGAGGTGTTACCATAACACCGCAAACGTCCAATTCGAATTCATTGAGACGTAAACAAAAGCCAGCATCACAGGCACTTGTGCCAAATCAAAACAGACACAATACCCTATTAGGTTCGGTGCCCGTTTCAACTGCAACCCTTGTGAGCGTTAACTCCAATTTacgacaacagcaacagcaattaGAGTTCAGccGAGCTTTACGCTCAGATGCATCATTGGTTCCTCCCATACGACAAACGGCTTCCATATTTAAACAGCCAGTAACTGTGGTGCGCAACCATGAGAATAATAAAGTGAAACATGACCCCAAGCATGGTGGTCAAGACAAACCCAAACAATTGTTTTGGGAGAAACGGCTCGAATGTATGCGAGCTTGTCATGCCAGTGGTGAAGAGTTCGATGATATTATATTGCCAAAAAATTTACGAGCATTGGGCCCCAATGTTCATGAGCAAACCGTTATGCAATCGTTGGCTACCGCTCTGCATGTCCTCAACACTCCCGTTACGGGGCAAACTGCCACCAAATCTGAATTTCAACGTAACGCCCCAGCCTTTATCAATCCCGACCAACCGTTAATGCAAGCGACACTAGTGTCTGATGATGATATACGGCGACAAGAGGATAGAGTGAGTGTGGCGCGGCGTAAACTTCAAGAGGCGCTTAAGATGTGA
Protein Sequence
MNSNITIERKRVDCNALPKGWQREEVLRKSGISAGKVDVYYYSPAGKRMDSKPQLARHLGDAIDISSFDFQKGKFIHHLPLPSISLYRCSAAFTGDTNNSITTAGGGVTITPQTSNSNSLRRKQKPASQALVPNQNRHNTLLGSVPVSTATLVSVNSNLRQQQQQLEFSRALRSDASLVPPIRQTASIFKQPVTVVRNHENNKVKHDPKHGGQDKPKQLFWEKRLECMRACHASGEEFDDIILPKNLRALGPNVHEQTVMQSLATALHVLNTPVTGQTATKSEFQRNAPAFINPDQPLMQATLVSDDDIRRQEDRVSVARRKLQEALKM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00746712;
90% Identity
iTF_01115010; iTF_01114257;
80% Identity
-