Gspa032758.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Globia sparganii
Gene Symbol
egg
Assembly
GCA_949316385.1
Location
OX438680.1:7485885-7538893[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.4 2.2e+04 -3.8 0.0 29 38 1901 1910 1872 1911 0.72
2 2 1.6e-12 5.7e-09 36.5 0.0 4 73 1942 2004 1939 2008 0.88

Sequence Information

Coding Sequence
ATGAGTGATACAGAAGAAAAAAACAGTAATGATGAAGAAAAATCGCGAATAAATCAAGACGAAGGCAGCAAAAACCTAAAATTAATAACTGAGGGTAATGTATCATTAGATTccaataaaaatacagaaaatagtgGCGCGATACCTGAAAATGTGCCTTTAAAAGGGGCTGGAGATGATAAAGTACGTATTTTACTAGATAACTTAGAACTTGACAAAATAGAAGCAGAGGTGACAGAAATTTCAAAGGAAATCATAATTACTGCTGCAGGCAAAGATGCTGGTGACTATACAGACAAAGCAAAGATCAGTGCAAtagatgataaaaaaattgaggATGTTAACACTGAAATTGATGCAAAAGTATCTAAAACCAATCTTACTGTTGAGAAAGATGAAAGCGATGATACTTCCCTCGACAAATGTAATGAAAAGGGATCTAAGAAGGCTGATGATCTTGATGAAATTGAAGATGAAGATATGGAACTAAGatgggatgatgatgatgatgatgctagcATTCATGCTGTCAGTGATGATAACAGAAACGCAGACGCTAAGAATGATGATATTCTGTCTGAAGGCCAACTTTTGGAAGATCCGTCAGATGTTTTAACTAAAGATATGACTGAAATGCCTTCTGATGGGAATCCTAAAGTTTCTGAAGCCAATCTTGATAGTGATCAGTTAAAAATCAACAATGAAGAAAATAGTCTTACAAGAGATGATAATTCTAAAGAAATTGAAACTTCTAAAGAATCAGGAATTACTCCAAAACTGGACATTCCTAAAGATGAAAAAATTGTGGTAGATATGCATTTAGAGGAAAACAACTTAGATACTGAAGAAATAAATAGCCCAGAAATGGATTTTTCCACAGAAGAAAGTATGGATGGagatgatattaatgtcttaGAAGAGGAACTATTGGAAGAATCTGAAATTTTCACTGAAGCAACAGTCATAGCTCCGGCAAAAGAGATTCTTGAAGAGAAAAGTATGGATGAATCAATAAAAGAGACAGAATCTGCTAAAACCAATTTTCTAACGGAGGTTACTAATGATGAACAGACAAAAGAAGATCCAGTTGCCATTATTGACGAAGACCAACTTTTAGCTGAATCTAAAAGTAATACTGAAACGGAGTCTTCAACATTGAAGTTGAAATCTTTTACAGATgtcattttgaacaaaaataatgatgatattatCTCAGAAGAAAAGCTTTTAGAAGAACCTGATTCTAAGAGCGAAAGTTCTTTGATTATTTCTGATAAAGTTAATGAATGTTCTAAAATAGTTCCTGAAAAAGAGGCCCCAGTGAATAAAGAAGATTATGATGATGCTCTGCTAGAAGAAAAACTATTACAAGAAACGGAAACAGCTGAAATTATTCCTGAAAATGATACAACAATGGATGTTGATGATGAAGAAGAGGGAGAGTTACTGAAAGATGATGAATGCTTAGAAGATAGCTGTACTCCTATGGATGTGGACAACATTGACACATCTATTGGAGATCAGGCTAAGGTAGAAGAAAAGATTGTAGATCAAATAATGAATCAGTCTGAAGTAGCAAAGAAAGATATAGCTCTGACAATAGAAGACCAAACTAATATGTACTATGAAACAACTGATGAAGTTAAAAATATGGATCAATCTGATGATCAAAGCAGAACAATTGAGAAACATATTGATCAGCCAATCAAAGACACATCTAAAGCAGTAGATATTGTTCAAGATACACCTATTGAAGATGAAGTTAAAATTGATGAGCAAATTGTAGATCAAACTGTCTCTGAAAAAGAGAGAATTGATCAACAAATTGATGATCAAACTAAAATGGAAGACAGCAATAAAGATCGATTAATTCTTGAATCTAATACAAAAGAACAGTCTATTAAGAGTCCTATACAAACAGATGCACTCACTGTTTCTAATACTCATAACATTCTAGTTGAAGATCTAGAGAAACCTATTCTGGAAGAAACTATTCTTGTAGaagaaattcaaattaaaaaagatcCAGAAGAACTTACtgaaaatatatacaaagaCACTGATTTagacaaacctgaaaaaagtaAAGAAATGATCAGTTCAGACACTAGCTTAGATAACAACAAGGAGGTTGATGAAATTTCATTTTCTAACAACTCTTCAATATTTCTAGAAGATTCGTGTCCAATCAAAACTGACCATGGAGTACATAAACCAGACGTGATGCTAGAAATACCTACACAAGAACTAATTGACATGGATGATACAGATTTGTCTTTGAATTTAGACCAAAACGTTGATGACGACATCGTACATGACAAAACAATTGATGAAACTGTTGTTGATGATGTCAtagaaagtaataaaattgttactgATAATGCTACAGTCAGTGAGAAATCAGTAGAACAAGCTAAAGTAGATGAAGACACCCTAAAAGAAGCAGATCATAAAGCCTTAGCTACTGAATCAACACTTATTGATAAAATCATAGCTGAAGATGATGCAGAGAAACCAGTAGATCAAAAAGCCATAGATACTGAAATGACAGCTGTTGATAAAATCATTGCTGATGAAGACACAGTAAAAGAAAAATCAATAGTTCAAGAAGCCATAGTAACTGAATCAACAGTAGGTGAAGTCCAAACAGTAAGTAATACTGTGGAAAGTGACAAAAAAGTTGAAGATAACGTTGTTCAAGCAACAGTTGAAGAAAACATGGAAAGattgtttgcagatgatgaTCCAGAAGTGGCTAAAGAAATTGCAGAGTGCATTGCATCCACAAGCCAAGTCCAAGTACCTGCCGAGCAGCCATCAACATCCATAACCCGTATGACTCCAGACACATCGGATGAAGTTCCAGAGATAGATGACAGTCTGGGTCTGTTGGCTGAGTCTGCAGGACGGATGATGGAAGACGATGAGGAGCCTGATGATGACTTTGacggtgatgatgatgatgattttgataatgatgAAAGCAGTAACCAAATTTCAGCAGAACAGTCGGAGGATTCGAATCCAGCAGCATTAGAGTCTGAACTAGCAAGAGACCAGGAAGACAAGGAGTTGGAGACTTCAGACCCTAAGGATGAAGAGTTCATGATGTGTGACAGTCCATCCCAGGATAAGGCGGAGAAGATGGATGTGGAAGGGGCATATGGGACTgTGGAGTTCCAGGCGGAatcaataaatgaaataaatgacgAGGCAAAGTCGGCTGTTGACGCGTTGTTGAACGCTGATATCCCCGCCAGTGAACAAGTTCAGGATCAACAAGAAACCACAGACCAAATGGACATAGAGACGGTGAAGCTGTCAGATACGTCCGATAACGAAGTTGATGTTGAACCTACGGAAGTTCAACAGGCTGTGGCTAAATCAAGCAAGGAGGGTGAAGaaaaacaaaagcgCTCACCTTCTAAATCACCAAGCAAGTCAAGCCAGTCGCCCTGTAAGCTATCCCCGAGCAAGATGAAGAATTTGGCCATCGCCACGCAAGCAGCTAGCGCGGTTGTCAATATTGTTGATTTAGAGGAGAGCAGCTCGTCTGAAGATGATATTCAAGAAGTACAAAAGCAACCGGAACCAGATACAACACAGGACGACACACCTCCTTCCCCAGAATCAGATGTTACCAACGTTAACATACCAACTGGTATAGACATAATGTGTACTTCCGGCGGAAATACGTCAGAGATAACGACTAAAGACAACCTCTCCCAGGTTGTTATCAGTGGCGTGCCCAAGCCGCCGCCGCATAAGCCTgcTAGATTGAATACCAGTGAAGTAACAATCAAAACTGCTAGTAATACAGAACCATTGATTATACCTGAAACTAAGATGAATGAGCAGACTCAAACAAAGTCTAAACATAAACTAAATCTAGAAATATTCAGTCTAGATTCTGACGACGATGAAAGCGCTGCTAAAGAAAAACCACCACCAACACCCCCTCACAAAATGACGGCCTTAGAACTAGAAAAAGCTCGAGAAACATCGAAGTGTATCAACTATTGTTGCACGAGCGACAACAAAGTGCCTTACAAGCTGGCGGAGGCGTCAGTGGTCGCGTACTACGACGCGGGCAGGAAGAGACGCTCCATGGTGTGCCAGCCATGCGCCGATGTGGTCGCTGCCAGGACTAAGAATCTAATTCAAGGAATAAAGGATCTAACTCCTCTCTTAGACTTAGAGATGGGCAAGTTATCACAAGACTTGGTGGAGATATCCGACTCGGAGTCTGAAGATGAGGATATGAATACTGACGAACCCAAGGAGAGTATCGGAGAGAAGGGGGCtaaATTCTTAGAAGACAATCTGGCCAAGTTTTTGAACGACACGTGGAAGAAATACGACATGGACGTGCGCCTCACAGAAACACAGATCATGTTAGATGATGAAATTGAAAAACTTGAAAagGACAGCAAAGAAATCGACGCAATGTTAAACGAGTGCCAGGTAGCGACAGACAAGCTTCGCTGCGAGTTATATGCGACGTTCGAGTGCCGGCGACAAAATCTACCCCCCTTAGCTATATACGACACGCCTGAGtctaaaACTCGCCAAGTCAAGCGGCGTTTGTCGTCAACCAGTGAGACTCCAGCCAAACGTCCCGCTATACCACTTGGATATACACCTTTAGATCGCGGCGACTCCAAGgaAAAAGCAGCAATCCCGGCACCAGATAGTAAATTAGATGATGACAAAGACATATCAGTAGTGAAACTATCAGCGGAAGCCGCCCCGGCAGAGCTGCCTCCCCCCGGAGAGATCTCCCGCCCGCCGCTGCGCGTGGGCATGCCGGTGTACGCCATGAAGAACGCCTTCGGACCCTGGCTTAAAGGCAAAGTGGTGGAGATTCAGCCCAAGAATACGTCTGGgGGCAGCCCTTTCTCTGTGTGTCTTGTGAAATTTGACCACAAAGTTAAGACTAATGGAAAAATGTTGCATGCTAGGTGCATCGCATATTCTGAGCCCGCTGATGTTAGAATGACTATCGGTACCCGCTTAATTGCCCTGTTCAAGGATTCGAACAAACGTGAATCATACTACTCAGGTGTTGTAGCCGAAATACCCAATCCAGTCAATAATTATAGATACCTAGTATTCTTCGACGATGGCTACGCCCAGTACGTCCAACACCAATTTACCCGTCTAGTCTGCGAAAGTTCTCCCTTAGTGTGGGAGGAAGTACATCCATTCTCGCGGGAATTCGTCCGCCAGTACCTAATGGAGTATCCAGAGAGACCCATGGTCAGGCTGCATGAGGGACAGCATCTGAAGACTGAGTGGAACGGAAAATGGTGGTCATCTCGAGTGACCCGCGTGGACGCGTCGCTGGCGCAAGTGATGTTCGTGGGCGACGGGCGGCGCGAGTGGATCTACCGCGGATCCACGCGCCTCGCACCGCTCTACCTCGAACTGCGCGCCGCCGAGCGACACCGGCCCAGACCCATGCCAAGGAGCAAGGCGCAGCCTAGGttcAATATGCCGTACGTGGAGTACACTCGGTCGGATGAGCAGGAGTCGAACAAGCAAGTGGATGCGCAGGCGCAGCCACAGCAAgaacagcagcagcagcagatACAAAATGAGGAGATACGTCGCCAACGCGCCGTGGCCAAGAAGTCTACCTCAGCTCCTCCGCAAGTGCTCCCGCCATCACAACAGGTTATGCCCACAAACCTGGATACTGTCACCAGCAGAGTTGTGTACTACACACCAAAGAACGCGGTGAAACCATTGAAGATGGTGCCACACAGATGTGGTCCGAGATGCAAGAGAAGCGATGTACTCTCACTAAAAGAGTTGAGGACTTATAATCCTCTAGCTAAACCACTGCTCAGCGGATGGGAAAGACAAATTGTCCGCTTCAAGGGCCACAAGGAAGTGATGTACCGAGCACCCTGTGGCCGTCGCTTACGAAACATGCGCGAGTTACATCACTACTTACGTTCTATCGACAGCGACTTGCCTGTAGATCTGTTTGATTTTCACTACTCTACGCATTGTCTGGCAGAGTTCGTGCTCAACAAGTgtttagttgggaaaaagGACCTCTCCCACGGCAAAGAGAACGTCCCGGTGCCCTGCGTGAACTACTACGATGACTCGTTACCGGAGTTCTGTTCGTACAACACCGAGCGCACTCCCACAGCCGGCGTGCCGCTCAACCTGGAGCCCGAGTTCCTGTGCGGCTGCGACTGTACCGATGATTGTCAGGATAAATCAAAATGCGCTTGTTGGAAAATGACGCTAGAGGGCGCTCGCACCATCGGGCTACGTGGACCTAATTTGGGCTATGTGTACAAACGATTGCCTGAACCGTTACCTTCTGGTATATACGAGTGTAATTCTAGATGTAAATGCAAGCACACATGTCTAAATCGCGTGGCGCAACATCCACTACAATTAAAATTACAGGTGTTCAAAACTCCAAACCGTGGTTGGGGCATCCGGGCACTGAACGATGTGCCAAAAGGCTCGTTCCTATGTGTTTACGCTGGTAACCTTTTGACTGACGCTACGGCTAACTTGgACGGTTTGAATGAGGGCGATGAATATTTAGCAGAATTAGATTACATAGAAGTTGTGGAACAGATGAAAGAGGGGTACGAAGAGGATATTCCGGAGGCCGACAAGAAATTAGACAAGAAAGAAGGTAAGGATGGTGACGACAGTGACGAGGATGAGCAGTCATCCTCCGAGGATGAGGAGACGGCCGATAAGAATGACAAGGAAGATGATGACTTCAGACCGGGATACATTGGACTTGGCGTTACGGAGTTCAGCAAACGCCTCCGTAAACGCGAAAaatcaaagaaagataaagaaAACGCGGCGGGTGATGAGAAAGAAAAGGACAAAGATACGACTAAAGAACCGAATGCTGAAGAAGATTGTATTACTATTAGTGACGATGAAGAAGTAAGAGAACCTTCAAGATTCATGGCGCAAACGAACATGGGAGCTAGcgaatatatttctaaatacaaGTCTGTTCGCACGTTATTCGGTAAGGACGAGGCGTGTTATATCATGGACGCTAAGGTTCAAGGTAACATTGGCAGATATCTCAACCACTCTTGCTGCCCGAATGTGTTCGTACAGAACGTGTTCGTGGACACCCACGACCCTCGCTTCCCCTGGGTGGCGTTTTTCGCGCTCTCACACATCAAAGCAGGCACCGAGCTCACTTGGAACTACAATTACGACGTGGGTTCGGTTCCCGGGAAGATACTTTACTGTTATTGTGGAGCTCCTAACTGTAGGGGAAGACTGTTGTAA
Protein Sequence
MSDTEEKNSNDEEKSRINQDEGSKNLKLITEGNVSLDSNKNTENSGAIPENVPLKGAGDDKVRILLDNLELDKIEAEVTEISKEIIITAAGKDAGDYTDKAKISAIDDKKIEDVNTEIDAKVSKTNLTVEKDESDDTSLDKCNEKGSKKADDLDEIEDEDMELRWDDDDDDASIHAVSDDNRNADAKNDDILSEGQLLEDPSDVLTKDMTEMPSDGNPKVSEANLDSDQLKINNEENSLTRDDNSKEIETSKESGITPKLDIPKDEKIVVDMHLEENNLDTEEINSPEMDFSTEESMDGDDINVLEEELLEESEIFTEATVIAPAKEILEEKSMDESIKETESAKTNFLTEVTNDEQTKEDPVAIIDEDQLLAESKSNTETESSTLKLKSFTDVILNKNNDDIISEEKLLEEPDSKSESSLIISDKVNECSKIVPEKEAPVNKEDYDDALLEEKLLQETETAEIIPENDTTMDVDDEEEGELLKDDECLEDSCTPMDVDNIDTSIGDQAKVEEKIVDQIMNQSEVAKKDIALTIEDQTNMYYETTDEVKNMDQSDDQSRTIEKHIDQPIKDTSKAVDIVQDTPIEDEVKIDEQIVDQTVSEKERIDQQIDDQTKMEDSNKDRLILESNTKEQSIKSPIQTDALTVSNTHNILVEDLEKPILEETILVEEIQIKKDPEELTENIYKDTDLDKPEKSKEMISSDTSLDNNKEVDEISFSNNSSIFLEDSCPIKTDHGVHKPDVMLEIPTQELIDMDDTDLSLNLDQNVDDDIVHDKTIDETVVDDVIESNKIVTDNATVSEKSVEQAKVDEDTLKEADHKALATESTLIDKIIAEDDAEKPVDQKAIDTEMTAVDKIIADEDTVKEKSIVQEAIVTESTVGEVQTVSNTVESDKKVEDNVVQATVEENMERLFADDDPEVAKEIAECIASTSQVQVPAEQPSTSITRMTPDTSDEVPEIDDSLGLLAESAGRMMEDDEEPDDDFDGDDDDDFDNDESSNQISAEQSEDSNPAALESELARDQEDKELETSDPKDEEFMMCDSPSQDKAEKMDVEGAYGTVEFQAESINEINDEAKSAVDALLNADIPASEQVQDQQETTDQMDIETVKLSDTSDNEVDVEPTEVQQAVAKSSKEGEEKQKRSPSKSPSKSSQSPCKLSPSKMKNLAIATQAASAVVNIVDLEESSSSEDDIQEVQKQPEPDTTQDDTPPSPESDVTNVNIPTGIDIMCTSGGNTSEITTKDNLSQVVISGVPKPPPHKPARLNTSEVTIKTASNTEPLIIPETKMNEQTQTKSKHKLNLEIFSLDSDDDESAAKEKPPPTPPHKMTALELEKARETSKCINYCCTSDNKVPYKLAEASVVAYYDAGRKRRSMVCQPCADVVAARTKNLIQGIKDLTPLLDLEMGKLSQDLVEISDSESEDEDMNTDEPKESIGEKGAKFLEDNLAKFLNDTWKKYDMDVRLTETQIMLDDEIEKLEKDSKEIDAMLNECQVATDKLRCELYATFECRRQNLPPLAIYDTPESKTRQVKRRLSSTSETPAKRPAIPLGYTPLDRGDSKEKAAIPAPDSKLDDDKDISVVKLSAEAAPAELPPPGEISRPPLRVGMPVYAMKNAFGPWLKGKVVEIQPKNTSGGSPFSVCLVKFDHKVKTNGKMLHARCIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQFTRLVCESSPLVWEEVHPFSREFVRQYLMEYPERPMVRLHEGQHLKTEWNGKWWSSRVTRVDASLAQVMFVGDGRREWIYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRFNMPYVEYTRSDEQESNKQVDAQAQPQQEQQQQQIQNEEIRRQRAVAKKSTSAPPQVLPPSQQVMPTNLDTVTSRVVYYTPKNAVKPLKMVPHRCGPRCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRFKGHKEVMYRAPCGRRLRNMRELHHYLRSIDSDLPVDLFDFHYSTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLRGPNLGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTPNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPEADKKLDKKEGKDGDDSDEDEQSSSEDEETADKNDKEDDDFRPGYIGLGVTEFSKRLRKREKSKKDKENAAGDEKEKDKDTTKEPNAEEDCITISDDEEVREPSRFMAQTNMGASEYISKYKSVRTLFGKDEACYIMDAKVQGNIGRYLNHSCCPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKILYCYCGAPNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00037842;
90% Identity
-
80% Identity
-