Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.092 76 3.4 0.1 26 45 42 61 33 67 0.89

2 6 0.00016 0.13 12.3 0.5 26 48 110 131 97 135 0.84

3 6 0.0065 5.3 7.1 0.1 19 42 174 197 166 206 0.82

4 6 5.3 4.4e+03 -2.2 0.0 27 39 220 232 216 241 0.81

5 6 0.00018 0.15 12.1 1.0 27 48 244 265 239 269 0.93

6 6 0.32 2.6e+02 1.7 0.0 39 50 328 338 323 340 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.092	76	3.4	0.1	26	45	42	61	33	67	0.89
2	6	0.00016	0.13	12.3	0.5	26	48	110	131	97	135	0.84
3	6	0.0065	5.3	7.1	0.1	19	42	174	197	166	206	0.82
4	6	5.3	4.4e+03	-2.2	0.0	27	39	220	232	216	241	0.81
5	6	0.00018	0.15	12.1	1.0	27	48	244	265	239	269	0.93
6	6	0.32	2.6e+02	1.7	0.0	39	50	328	338	323	340	0.74

Coding Sequence: CTGCGGTCGGAGAACATTTTCGTGCCCGATGCCCAGGTTCCTGGCACCTATTTCTGCACAGTGTGCTCGAAGGCCGTCCGGAACAAGTGGCACCACATGCAAGTACATTTCCCCGGAGTTCATAAGTGCACCATTTGTGAAGCAGTGTATACCCGTGTTGATAAGCTGAAAGCCCATCTTCgatCGAGCGATACATTTGCAGGGACTGAAATATCTCATTTAGATTTCTATGAGAAACTACCGTTTGGTCAGGCTAAGTGTAAACTGTGCGGCCGAATAGTTTTGCACATGAAAAGCCACTTCAAGACTCATAAGCCTGATAAACGGCAATGTCCTATTTGCCGGTTGACAATGCGCTCAGACAATATTAAACGCCACCTCAGAGACAGACATGGCGTTGCTCACTCATCATCAACCAACGAATTATCCCACAAACTATTTTTTGAGAGACTTCCCAATGGATTGATAATGTGCAAGATCTGTGGCAGGGCTGTCTCGCACATGAAGAATCATTTTACAACCCATTCAAATGAAAGAGCTCAGTGCCCAGTCTGTTTTGTGTATCGTTCTAGGCCAGACAACTTAAAGCGGTCTAAAGTGTGGCACATGCGGCTGACCTTTGAGCGGATCCAGGGAGTGGCCAACAACTTGCACCGCTGCCGACTGTGCGGCAAGGTGGTGACCCACGTCCGAAACCACTACCACGTGCACTTCCCCGGCCGCTTCGAGTGTCCCCTGTGCCACGCGACCTACACGCGCAGCGACAACCTGCGCACGCACTGCCGCTTCAAGCACCCGCTCTTCAACCCCGACCTCAACAAGttcctcgcgcgcccgcccaccgggTCCCTGCCGTCTCCGTCCCCCTCGCCGGGTCAGTCCGCGGGAGCGCAGGACCTCGCGACGACGtcgaggggcggaggcgggggtggttctgggggcggcgggggcggtgggggagggagcggccggtccagcagcagcctgcgcgACTTGGAGCTCAAGCACTTCGGGGACATGATGGGGGAGCGCGACAGGGATGGAGAGGACGCCAGCGACAAGTCCTCC
Protein Sequence: LRSENIFVPDAQVPGTYFCTVCSKAVRNKWHHMQVHFPGVHKCTICEAVYTRVDKLKAHLRSSDTFAGTEISHLDFYEKLPFGQAKCKLCGRIVLHMKSHFKTHKPDKRQCPICRLTMRSDNIKRHLRDRHGVAHSSSTNELSHKLFFERLPNGLIMCKICGRAVSHMKNHFTTHSNERAQCPVCFVYRSRPDNLKRSKVWHMRLTFERIQGVANNLHRCRLCGKVVTHVRNHYHVHFPGRFECPLCHATYTRSDNLRTHCRFKHPLFNPDLNKFLARPPTGSLPSPSPSPGQSAGAQDLATTSRGGGGGGSGGGGGGGGGSGRSSSSLRDLELKHFGDMMGERDRDGEDASDKSS

Sequence clustering based on sequence similarity using MMseqs2