Basic Information

Gene Symbol
Zfa
Assembly
GCA_947568875.1
Location
OX387654.1:7776778-7786126[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.0094 0.99 10.8 1.6 3 23 742 763 741 763 0.96
2 23 0.2 22 6.6 0.3 1 22 1147 1168 1147 1168 0.95
3 23 7.4 7.8e+02 1.7 0.4 1 22 1210 1231 1210 1233 0.82
4 23 0.016 1.7 10.1 4.8 2 22 1243 1263 1242 1263 0.93
5 23 0.59 62 5.2 0.1 3 23 1272 1293 1270 1293 0.89
6 23 0.017 1.8 10.0 0.2 3 23 1314 1335 1312 1335 0.96
7 23 0.0032 0.34 12.3 2.5 1 23 1341 1364 1341 1364 0.95
8 23 0.12 13 7.3 0.0 1 23 1390 1413 1390 1413 0.90
9 23 0.018 1.9 9.9 3.4 1 23 1418 1440 1418 1440 0.97
10 23 0.0085 0.9 10.9 0.2 1 23 1446 1469 1446 1469 0.95
11 23 0.004 0.42 12.0 0.8 1 23 1482 1504 1482 1504 0.97
12 23 0.00017 0.018 16.3 1.8 1 23 1554 1577 1554 1577 0.97
13 23 0.0026 0.28 12.6 0.9 1 23 1637 1660 1637 1660 0.95
14 23 0.0023 0.25 12.7 2.1 2 23 1687 1709 1686 1709 0.95
15 23 0.039 4.1 8.9 0.1 2 23 1715 1737 1714 1737 0.94
16 23 0.0097 1 10.8 0.2 1 21 1781 1801 1781 1802 0.95
17 23 0.00041 0.044 15.1 1.0 1 23 1812 1834 1812 1834 0.93
18 23 0.00011 0.012 16.9 0.3 2 23 1927 1949 1927 1949 0.93
19 23 3.9e-07 4.1e-05 24.6 1.4 3 23 1956 1976 1955 1976 0.98
20 23 0.0092 0.97 10.8 0.5 1 23 1994 2016 1994 2017 0.96
21 23 0.18 19 6.8 0.0 1 23 2040 2062 2040 2062 0.97
22 23 0.027 2.9 9.4 0.6 1 23 2068 2091 2068 2091 0.95
23 23 0.00025 0.026 15.8 0.4 1 23 2099 2122 2099 2122 0.96

Sequence Information

Coding Sequence
ATGAATGTGAACTATGATCGTGTTTGTAGACTGTGCTTGTCATCTCGAGGCGAATTACTGCCGATTTTTCCTACCACCAGTTCGGATGACTCGGAACCTCCCGTCCTCGCTTTGAAAATCAAGGATTGTGTGTCCGTACAGATAAACGAAAATGATGATCTGCCCACTAATGTCTGCAGGAAATGCATGGACAATGTCAATAACTGGCATGTTTTTAAAAATGTATGTGAAAAGACACAAAACAAACTACAGTCTCTGAAAGATGGCAGCCAACTAGAAGAGGTGAAAATAAAAAGTGAACCACTATCTGATGGGGCTTATGATGATGGAGTGGTCATTGATGGCTCATATCCTGTCATTGAGAATGCTGGCTTTTCAAACAAAGTGCAACCTGAAGGTCCCCCAATCTTGGCTTCATTGGGGCTTACACCAAGAAGTGATAAGAAATGTGTGGACCCGCGAATGGATTGGCATCGGGTCCATGCAATTTTGGACATGGTTCAAGACAATGAGGTGATTGACTCTCTGCAGGCAAAGGAAGAGTGTGATGTTTTGCAACATTCTGATCATGACTCGGACACAGAAGCCGAACTCCAACCAGAAATCGATGATGATTATATTGATTGCAAAAGTGGTTACATATGCAAAAATAAAAACATTATGTCAAAAGTTCCAAAACTATCAACTTCTGTAAATAATGCCAGAGTCAAAGAAGCTTTCAAACTGAGAAAACGTAAATCAGAAGTTCGTAAACATTGTTCACAGCCTAAAAATGCGTGGCAGTTGTTATTCACCAATGACCTACTAGAATTGATTGTTGCTTCTACTAATGAAAATATTGTGACAAATGGGAAAAGTTTCACGGAGTCGACCAGTGTCGGCGAAATTAAAACGCTTATCGGTATTCTGTATCTGCACGGCATAATGCGGCCGACGCATCAGAAATGTAGCGAACTTTGGAACAGTGAATGTGGTGTTCCTTGCGTCAGAAAGGTCATGAAGTACGAAAGGTTCAAATTCCTGCTTCAAAACATGAGCTTCGATAAAGAGGACGACGATAGCATTATACAGTTCGACATAATGAAGCGTATGCGTAAAGTATTCGAAATCTTCGCCATGAATTGCAGAACATTTCATGAGATCGAGAATGCCGCGGTTATTGATGAGATCATCGTGCCAGTTTACGGACCTTGCCCGTTTCGATACGATATTGATAAGAAACCGCTGAAGCGGGGCATAAAAATGGTACTGCTAGTTGATTCATCCACATTCTATATGAGCAATTTAGATGTCATTACTGATCCCTATTTTGGCGCCGAAGATATAACGAAAAAGTTGGTTCAGCATTTAGCTGGAACTGGCAGATCTATTGTTATGGATAGTTGGTTTACATCTTCCTCATTGATTGATAGCCTTAGAAATGAGTACCAGTTGTATTCTATTGCAGCTTTGAACCCAAACAGTGATATGATTCCACCACTATTCCTATCTCAATACAGGAAATGTCGAACATTCATGTCTGGATTTATTGATCATGAAGTATCACTGACATCTTATGTCAATACTCTGGGGAAATCAGTAAATGTATTGACTAATGAGCCTAGATATTACAGGAAAGGTCATATAAATCACACTACAGTTGTATCAGTGTATAAGAGGAATCAGTCTGCCGTAGAAGTTGTGGATGTTCTCATGAATTACTACACTACAATGCAACATACAAATGATTGGACATTGTCCTTATTCTTTACATTGCTGAATATTGCCTCTGTGAATGCTCAAGTGTTGTGGTGCTCTCAAAACTCGAATGTTACGCAGCGTCGCTTATTTATTAAAGAATTAGCGACTAGTTTACTAGAACCAGATGAAGAAAGAATGTTAATTTCTCCGATAAACGATTTAGAAGAAAGGAAAAACAAATTTTCTGTCATACCCAGTAATGTACAACCATATTATAAGAATAGGAGAAGGTGTAAGATATGTGTTAAGACGACGAAACGCGATAGGAGAACAAGACAGTTCTGTGTAAAGTGCGGCACTTTTATTTGTAAAGAGCATGCTGGTGCGGAAAGTGAAAACAATGAAGACGAGGAAGAAATGAGCGAGCCCGCCCAAAATTTCCCGAAAATGCCCCACATGCCCGAGGTGTCCATCACGGTCATGAGGCCTACAGGTGAAACCCTGCACGCTCGCCAAGGTATTCACCAACTGGCCTCCAAACTGTGCCTCGTCTGCGGCCGCTCCTACAGGTACTCCCACAACGCACGCAGGCATGAACTTACGTCTCACAGCTTCGACAGATATACAAACAAAATTACTCCTAAAAAAACCCTCAATCATCTACAACCCAAACTCAGACCGAACCCATTCAACCCCAAAGCACGGATGATGCCGAATCCTATTAGTCATAAGATGCAGTTCTTGAACAAGAACATGCCAACAAAAATAATGCCCATAAACAAAGTTATAATGCCACAGAAACCCATTCCAATAAAGACGTCAAAGACACAAAATAATTTGCCTTATCCTCTACGCATTAAAGCACTCAAAGATTTACAAATTAAGAAAAAGGAGCCTCAAATTCTAAAGACTTTGTTAACCTCTAAACCTGAAGTTCTGGTTTCCGAACCAGAAATTCTAAATTCTGGGCCTGAAAGCCCAGAAACATTGATATCTGAGCCTGAAATTGCATCTTTTCAAGTCGAAGCTATTCTTACGGAACCCGATGCCGATGCATACGATGATCCACAGCAAGGCGACGAAGAAGTTGATGAAGAAATGCAGAACAATCAAAGTCAAAATTATGACACAGTCGATATGGACTCTGAGAATGAAATAGAGATTGCTCGTCAGGACGGCATTGAACACGAAGGTGAGGAAAATGCAGATGGGGAAGAGAATATCGACCATGATGACGATAATAACATGGAAGGCGCTCAGAGCGATAACGAGAAAGACGGCAATGACGATACAGCTGAAAGTCAAGAGAACATTGAAGAAGAAGACAGTGTTGATATTAAACCAGAAGAAGACCAAATGAAGGACGAGGTCCCAGAGGAGGGAGAACACGAAGAATTAGAAATCAATCACAACGAAAACGAGGAAGAAGACGATGATGAACTTCCAATATCATTAGCGCCCGTCGTCGAAATAAGTGAGGGAATGCAAGTCGACTCGTTTAACAGCGAAGTCAATGAAGAAGATGAGGAACTCGATGAAACTGCCGATATCAATGCAACCATCGAAGATGAGGAGCAGATCAAAGAACTTGACCCTGACAAAACATATGTTACGAAAACCCAAAGAGACTTCATCCAGAAATATCGCGACATCATTCAGCAAATCAACACGAAGCGTTGTTTATGTTGCGATCGAGAACATCCGCGCCGAAAAGCTGTTATACAACACTTGCAGAAAAACGGACATAAGGTACCAAAACACACTTGTTACAATTGTGTCATCACGTTCGGACATATTGGCGCTCTACTCAGTCATATGAGGTCCAATTCTTGCACTAATTTGTGGAAGATTATTTACAATGAAAATGGCATTACTGACGACTTAGTTCTCGAAGATGAGCCGAAAGAGGTCAAGGTTGCATACAAAGATATTTTCAATGCTAGGTCATATGCTTGCAAGCTCTGCCCAGCTAAATTTCAACTGAAACAGTTTATTATGAAGCATGTTTTGGATACTCACGAGGATGGGCAGTCAAGGGTACCGCTCTGTTGTGTCCACTGCCGTTCTAGATTCAAAGATAAGAGCTTACTAAAGAAACACATTCGTAAAGGTGATTGTACAGTTTATATTGCTTGCGATTTGTGCTCAGAACAGTTCAGGAACATGCAGGACTTCAACGACCATGCGCTAGCTATCCACGCTGGCAGTTTCGATCAGTCGGATAATCAGAGCAAATGTGTTGATGGTCGACCAACAGACTGTCCTTTGTGCGGAAAGAAAAACAGCAGCTATCCGAATTTAGTGAAACATTTGAAAATTATACATGCGGAGGAGAAACCTCACTACTGCCAGCATTGCGACGCTAAATACGAACAAGCTACTGATCTAAACAAGCACATTTACATGGAGCATTCTGACAGAACATTAGGCATGCCGCCCGCTGAACCGGATATGTCCATAGTTAAGGAAGAGGCAGAGGAGTACCATTACTCCTGTACGGAATGTAACGCCATATTCGAAACTGTTGATGCGTGGACTGATCACCAAGTCGCCGAACATAACCAAGTGGCCCACCACTGTGACCAGTGTGAAAAGAAATTCCTTCGTCCTTCAGAGCTGGCAGAGCACAAGAACACTCACTTGAGGGTTAAGTTCTATCCTTGCAGCGTATGTCCCAACTCCTACAGCACGCCACAGAAACTGTCTGAGCATGTGCAACAGTCACATCCAGGAATTGGCGCAGTCGCGGCAACTGAGTCTGAATTCTTCTGCGACATCTGTATCAGAGCATTCAAAAGTCGCCAAGCTTACTCAAATCATATGCGTATTCACGCTAAAGTACCTACTACTAACAGGAAACCAGCTCCAGGAAAAGAGGGATTCGCACCTCAAATTATCGGGAAACCTATCAAACAATATCCTATGGTTCAACCTGGTTTTGTGTCATTTAAACCTAATTACAACATCCCTAACGCTCCATATTCATGTGACATTTGTGGTAAAGGATTCATGCACAAGAAGAATATATGGAAACACAAGAAAGTGTTGCATGCCGATATTTTAGTCGATAGACATGACAGTGAAGAGAACACTATGCAAGCTTCCACAGAAGAGGAGGAATTCAACCCTGATGAGAATGGTGCCATTCTCTCAACGCCACAATTTAATAGTTTTAACTTCACGAACTTCCAGAACAATGCTCAGCAAACACCACCAGATACAATGCCTTATGCGTGTGATTTATGCAGCAAACGGTTCCCGCTTAGGACCAGTTTATGGAAACACAAGCGCGCTAAACACGGAATCGTAAACCCCAGTGCTAGTAGTAGCAACGATACATCCACGCCGTCGGCTAGTGGGGAAGGCAGTAGTAGATCTAGCTGCACTATATGTAGAATTACATTTTCAGATAAGAAATCTTATTATCGTCATCGAAAGAATGTCCACAAATCTACCGTTCAAATGTGTAAAATATGTGGCAAACCTCTAAGTTCAACTTTGGAACTATACGAACACTTGAAAGCTGCTCATGCAAGGGAATTACTGGGTTATAACGCTAACCAAGGCTCCAGTAAATCACAAGATATATCACAAGAGGTGGAACCCGATTATGAAAATGATCAGGAGTCTGTCGACCCCAGCGTTGATTATCAAGCGCGCTATCCGTGCGATACTTGTGGCAAACAATTTGTGGGTTTGCTTGCGTTGCAGAACCACCAGTGCATCAATCAGATACCAACACAACCACAGACGTTTGACTGCGAGATTTGTCACAAGAGTTACACTTCAATATCTGCACTAAAAAGCCATCGTGGGTGGCATTTGCGTTCACCCGATGGAAAAGCAGCCGCCAACAATTCTGGCCTATGGATGCCTCAGCACAAAGTTACTAGCAAGATAAGCAAACATGAGGTCATCGACCCGTCACAACTTGCTAAGGTTACACATACCCCCACTCCTCCTCCTGTCACTGCTACCGCAGCGAAAAGAAGACTACCACCAGAAGTCGAAGTGACAGTCGTAAATCCAAACAAGAAACTGCGCTCAGACGACTCGGTCGACTTGGATATGCAAAGTACTGGTGCAATCGAGGATAGGTACTGTACGATTTGCGACAAGGAATTTACAAAACGCGCGGCGTATCAGCGCCACATGGACGAGGTACATCAACCTAACTCTGTGTTTTGCCCGGTTTGTGATAAGAGTTTTACAAGGAAATCCACATTGCTCATTCACATGAAGAAACACTACGAGAGCGGTGAGGGCAGTTCCTCTGCTACAGGCCAAGGGGACGATGATTACTCCTGTGATTTGTGTGGCGCTCAGTATGACAATGATCAGGCGTTGAGGGCGCACCGAATGCGGCACCACGGAGAAGATGAAGATTCGGCAGAAGAGAGTGACGACGGAAATGTTCCTATTGCTCCTCCCGGTGAGTTCACATGTGCGCAGTGCGGCGATGGCGTGGCTACACCAAGAGACCTCATCGCCCATCGCACAATGCATGCTACTCCCACCAAATTCTTCTGTAACATATGTAAAGTGTACTTCGCCCGGGCGCTCGACCTCTCCTCGCACACTCGGGCGCGACACGCTGACAACGAAAAGGTATTCTTCCCATGTGCCATGTGCGACAGGTTTTACATGAACAAGAAGAGTTTACAGCGGCACATCGAGATGGCTCACTGA
Protein Sequence
MNVNYDRVCRLCLSSRGELLPIFPTTSSDDSEPPVLALKIKDCVSVQINENDDLPTNVCRKCMDNVNNWHVFKNVCEKTQNKLQSLKDGSQLEEVKIKSEPLSDGAYDDGVVIDGSYPVIENAGFSNKVQPEGPPILASLGLTPRSDKKCVDPRMDWHRVHAILDMVQDNEVIDSLQAKEECDVLQHSDHDSDTEAELQPEIDDDYIDCKSGYICKNKNIMSKVPKLSTSVNNARVKEAFKLRKRKSEVRKHCSQPKNAWQLLFTNDLLELIVASTNENIVTNGKSFTESTSVGEIKTLIGILYLHGIMRPTHQKCSELWNSECGVPCVRKVMKYERFKFLLQNMSFDKEDDDSIIQFDIMKRMRKVFEIFAMNCRTFHEIENAAVIDEIIVPVYGPCPFRYDIDKKPLKRGIKMVLLVDSSTFYMSNLDVITDPYFGAEDITKKLVQHLAGTGRSIVMDSWFTSSSLIDSLRNEYQLYSIAALNPNSDMIPPLFLSQYRKCRTFMSGFIDHEVSLTSYVNTLGKSVNVLTNEPRYYRKGHINHTTVVSVYKRNQSAVEVVDVLMNYYTTMQHTNDWTLSLFFTLLNIASVNAQVLWCSQNSNVTQRRLFIKELATSLLEPDEERMLISPINDLEERKNKFSVIPSNVQPYYKNRRRCKICVKTTKRDRRTRQFCVKCGTFICKEHAGAESENNEDEEEMSEPAQNFPKMPHMPEVSITVMRPTGETLHARQGIHQLASKLCLVCGRSYRYSHNARRHELTSHSFDRYTNKITPKKTLNHLQPKLRPNPFNPKARMMPNPISHKMQFLNKNMPTKIMPINKVIMPQKPIPIKTSKTQNNLPYPLRIKALKDLQIKKKEPQILKTLLTSKPEVLVSEPEILNSGPESPETLISEPEIASFQVEAILTEPDADAYDDPQQGDEEVDEEMQNNQSQNYDTVDMDSENEIEIARQDGIEHEGEENADGEENIDHDDDNNMEGAQSDNEKDGNDDTAESQENIEEEDSVDIKPEEDQMKDEVPEEGEHEELEINHNENEEEDDDELPISLAPVVEISEGMQVDSFNSEVNEEDEELDETADINATIEDEEQIKELDPDKTYVTKTQRDFIQKYRDIIQQINTKRCLCCDREHPRRKAVIQHLQKNGHKVPKHTCYNCVITFGHIGALLSHMRSNSCTNLWKIIYNENGITDDLVLEDEPKEVKVAYKDIFNARSYACKLCPAKFQLKQFIMKHVLDTHEDGQSRVPLCCVHCRSRFKDKSLLKKHIRKGDCTVYIACDLCSEQFRNMQDFNDHALAIHAGSFDQSDNQSKCVDGRPTDCPLCGKKNSSYPNLVKHLKIIHAEEKPHYCQHCDAKYEQATDLNKHIYMEHSDRTLGMPPAEPDMSIVKEEAEEYHYSCTECNAIFETVDAWTDHQVAEHNQVAHHCDQCEKKFLRPSELAEHKNTHLRVKFYPCSVCPNSYSTPQKLSEHVQQSHPGIGAVAATESEFFCDICIRAFKSRQAYSNHMRIHAKVPTTNRKPAPGKEGFAPQIIGKPIKQYPMVQPGFVSFKPNYNIPNAPYSCDICGKGFMHKKNIWKHKKVLHADILVDRHDSEENTMQASTEEEEFNPDENGAILSTPQFNSFNFTNFQNNAQQTPPDTMPYACDLCSKRFPLRTSLWKHKRAKHGIVNPSASSSNDTSTPSASGEGSSRSSCTICRITFSDKKSYYRHRKNVHKSTVQMCKICGKPLSSTLELYEHLKAAHARELLGYNANQGSSKSQDISQEVEPDYENDQESVDPSVDYQARYPCDTCGKQFVGLLALQNHQCINQIPTQPQTFDCEICHKSYTSISALKSHRGWHLRSPDGKAAANNSGLWMPQHKVTSKISKHEVIDPSQLAKVTHTPTPPPVTATAAKRRLPPEVEVTVVNPNKKLRSDDSVDLDMQSTGAIEDRYCTICDKEFTKRAAYQRHMDEVHQPNSVFCPVCDKSFTRKSTLLIHMKKHYESGEGSSSATGQGDDDYSCDLCGAQYDNDQALRAHRMRHHGEDEDSAEESDDGNVPIAPPGEFTCAQCGDGVATPRDLIAHRTMHATPTKFFCNICKVYFARALDLSSHTRARHADNEKVFFPCAMCDRFYMNKKSLQRHIEMAH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00017541;
90% Identity
iTF_00447463;
80% Identity
-