Basic Information

Gene Symbol
-
Assembly
GCA_947363495.1
Location
OX376176.1:3213945-3250052[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9.1e-16 4.2e-12 46.1 0.0 7 70 266 327 263 331 0.87

Sequence Information

Coding Sequence
ATGTCTGAGGAAATGGCGATTGGTGATAACGCTACTAACGAAGAAGCCAAGTTGAATGGCGATGAAGCGTCTGCTGCGAGCGCGGTGGATGCTGACACGGCCGCCCCGGCTGCTCCGGAGCCTCAGACCGAGCCTGAAGCACCTCCGGTGGAGGATGCGCCAGCACTAGCAGAAGAAGTACCAGAAGTAAAAGAAGAAAAACCTGAGGATGTTGCAATGGCGAAGCCTGAACAACCTACAGACAAGCCTGTTGCAGGAGATGGAGCCGACGAAGGGGATGAAAAGAGAGGCATCAAACGAAGGGCTTCTGCAGCCTTCAGCGATGCCAGCAAAGATGACTTTAAAGGCTTTGATTCTGTTGATAAAAATGAGTTTGAAACATCGTACAGTGAAGTGTACAGTCGGATTGTTGATCGGTTGGAAGCGGAAGTGACAGCGGCCGTCAAGAACCTCACACCGCTCCGTTCTGTGATGGCCACTCCTCCCGTGCCGTCCCGAGCCAGCAAACGCCCGCGACAGGATACCGGTGAGAACCTAGCGAACCTAGAGTTAGACCCACTTGCTAAAGAGCTGTCTGAAGCGGTGAAGGATTTGAATATGACCGCGTTGCCATCAATGACTGCTCCCCTTAAAAAACGTCCGTCGCGGGCGTTGGATGTGGATGGATCCAGGCCTTCATCAGCCTTATCGTCAAGGTCTGATGGTGATGGAGTTATCTCTACTGATACGACAAGTGCAGCATCGTCGCCAGGCCATCGCGGTCGACGGGCCACCACCGACATGTGGTCTCCGTTGCTCCGCGTGCCGCTGGAACACGGCTGGAAGCGGGAACTGGTGTACCGCGCTGCCTTGGACTCGCACTCGAGACGGAACGCTGATATATACTACTACACGCCCGCCGGGAAGAAACTGCGCTCCACCAGAGAGGTAGCAGAACATTTGTCCGGTACTGGACTGACATTGGAGAATTTCTCATTCTTCAAAGAACCGCTGGGAATAGACGATCCTGAGAAGGAGATAATACGTGACGCCAAACTGATGCGTCGCGTGGAGTCCCCGGTAGCAGCCCCCCCTCCCCCACCGGTGGAGGGCAAGCGCACCCCCAAACCCAAGGCTCCGAAAGGGGCCAGCCCCGAACCAGTTGCAACTAATGTTAAATCTCCACCGGCTAAAATCAGGGTGAAGTCGGTAGGCTCCAGACTGAGCACGAGCTCTCCGTCCACCCCGACAACAAACACCAAACAACAGAAGAAAACGGCAACAACGGAAAACAACAACTCGGCCGCTTGGAAGAAACCCAGACCGCTGGTGGCGCCGGCTACGACGCCCGCTGCTACGCCGCCCGCTACGACTGCTACGACTGCTACGACGGCGGTATCGGCTACGACGCCGCCGCAGCCGCCGCCGCCGCTGCAGAGTCGGCCGTCGCCGTCGCCCGATGTTACGTCCCCCCGCCAGCTAGTACAGCCGTGCTCGATGACATGCGGCCTCGGCTTGCCGACCGTGGCGTGCGCGGCGTGCTTGTGTCTGTACCACCCGTCGTGTATTGGGTGCAACTATAATGCCACGGGCCGGGTGCTTTGCAAGAACTGCCGGTCATCCCCCCCTCCGCTGGAACCGCCCCCCCTGACCCACAAGTCCGGGGTCAGCGTGTCCAGCCTGCCCGCGCCCGTGCCTCGGCGGGTACCCGGCCCGTTACCCGTGCCTGTACCCGTACCCGTACCCGTGCCCGTGCCCGTGCCGAAGGGTACGCGTCCGGATAAAAGAGTTACCTTGAGAATGAAGGTAGCGGGGGGCGGTCCAGACGGGGAGCGAGTTTGGGCGGTCGCACCGCAACCGCCTCCCCGGGCGGTGTTAATGCGGGCACAACTGCCGCAGTCCGTGGCCTTGCTGCACGGCCGGCGGTTCATCGTCGTGCCGCGTGACATACGACCGCTCAATGAAGACAAGAAACGTGGTCGAGTGGCAAACGGTGCCGCGTCGCCGCCGGCCGTTTTGACGTCGCCAAGAAGACGCGGAAGGCCTAAAGTTGACGATACGGACCATTTCACTGCATTTTATAACACTGCTCAGGAGAGGAACTATAATGTTGTTGTACAGATCTTCCAATACCTGGGCATGCGTGAGCTAGCACACTCGGCGCGCGTGTGCAAGTTGTGGAAGCAACTGGCCGCCACGCCCGCGCTCTGGCGGCACGTTCGGATGAAAAACTCGCACGTTAGCGACTGGGGCGGACTTTGCGCAGCTCTGAAGCGCCACGGCACCAAACGTCTGGATTTGCGCAAAATGCTGCTGCCGCCAAACGATGCCACCTTTTGGGACCAGTTCGCGCAACATATCGGGGACGTGGACTCTTTAGAAAGGATAGAAATGTGCCGCTGTCCCGCACGCGCAGTAGAAGCTGTAAGCGCCAGCCTGCCATCTTTAAGATCGTTATCAGCGCTCGCTATACGAGACGCCAGGCTGGACCCGTCTCCTCTCGCGCGACTCACACTACTGCACGAACTGCGACTGAAGAGCATGGCGGGCCTCACACTAACCAGAGACCTGAGGCCTCTGGCCAGGCTCACGGCCTTGCAGCATCTCTCTCTCACTTCCATCAAGGAACTGGGCTGGTGCCTGTGCGACGTGATAGGGCAGCTGCCCGCGTTGGAGTCGCTGGAGCTGGGCGAGTGCTCGTTCCGGGCAGAGTTCGCGACGGCGCTGCGACGACTGACGCGGCTGCGGAGGCTGCGGCTGGAGCGCGGCACGGCACACTGTGCTGCTCCGGCGATCCTGCGAGCGCTCGCACAGCTGCCGCGCTTGCAGGCCATCGAGCTCGTTAATGTTGATGTCAAGGTGAATACTAACTGTGGACATAGACAGGCACGGCACACTGTGCTGCTCCGGCGATCCTGCGAGCGCTCGCACAGCTGCCGCGCTTGCAGGCCATCGAGCTCGTTAATGTTGATGTCAAGGTGA
Protein Sequence
MSEEMAIGDNATNEEAKLNGDEASAASAVDADTAAPAAPEPQTEPEAPPVEDAPALAEEVPEVKEEKPEDVAMAKPEQPTDKPVAGDGADEGDEKRGIKRRASAAFSDASKDDFKGFDSVDKNEFETSYSEVYSRIVDRLEAEVTAAVKNLTPLRSVMATPPVPSRASKRPRQDTGENLANLELDPLAKELSEAVKDLNMTALPSMTAPLKKRPSRALDVDGSRPSSALSSRSDGDGVISTDTTSAASSPGHRGRRATTDMWSPLLRVPLEHGWKRELVYRAALDSHSRRNADIYYYTPAGKKLRSTREVAEHLSGTGLTLENFSFFKEPLGIDDPEKEIIRDAKLMRRVESPVAAPPPPPVEGKRTPKPKAPKGASPEPVATNVKSPPAKIRVKSVGSRLSTSSPSTPTTNTKQQKKTATTENNNSAAWKKPRPLVAPATTPAATPPATTATTATTAVSATTPPQPPPPLQSRPSPSPDVTSPRQLVQPCSMTCGLGLPTVACAACLCLYHPSCIGCNYNATGRVLCKNCRSSPPPLEPPPLTHKSGVSVSSLPAPVPRRVPGPLPVPVPVPVPVPVPVPKGTRPDKRVTLRMKVAGGGPDGERVWAVAPQPPPRAVLMRAQLPQSVALLHGRRFIVVPRDIRPLNEDKKRGRVANGAASPPAVLTSPRRRGRPKVDDTDHFTAFYNTAQERNYNVVVQIFQYLGMRELAHSARVCKLWKQLAATPALWRHVRMKNSHVSDWGGLCAALKRHGTKRLDLRKMLLPPNDATFWDQFAQHIGDVDSLERIEMCRCPARAVEAVSASLPSLRSLSALAIRDARLDPSPLARLTLLHELRLKSMAGLTLTRDLRPLARLTALQHLSLTSIKELGWCLCDVIGQLPALESLELGECSFRAEFATALRRLTRLRRLRLERGTAHCAAPAILRALAQLPRLQAIELVNVDVKVNTNCGHRQARHTVLLRRSCERSHSCRACRPSSSLMLMSR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00146441;
90% Identity
-
80% Identity
-