Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.1 4.5e+03 -1.9 0.0 40 60 2 22 1 34 0.78

2 7 0.00031 1.2 9.6 0.0 34 64 35 65 27 73 0.86

3 7 0.00033 1.3 9.5 0.0 34 61 74 101 70 112 0.86

4 7 0.00033 1.3 9.5 0.0 34 64 113 143 107 151 0.86

5 7 0.003 12 6.4 0.0 34 59 152 177 146 189 0.84

6 7 0.00032 1.2 9.5 0.0 34 64 191 221 184 229 0.86

7 7 0.068 2.6e+02 2.1 0.0 34 47 230 243 226 253 0.83

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.1	4.5e+03	-1.9	40	60	2	22	1	34	0.78
2	7	0.00031	1.2	9.6	34	64	35	65	27	73	0.86
3	7	0.00033	1.3	9.5	34	61	74	101	70	112	0.86
4	7	0.00033	1.3	9.5	34	64	113	143	107	151	0.86
5	7	0.003	12	6.4	34	59	152	177	146	189	0.84
6	7	0.00032	1.2	9.5	34	64	191	221	184	229	0.86
7	7	0.068	2.6e+02	2.1	34	47	230	243	226	253	0.83

Coding Sequence: ATGGGAAAACGATCGGAAACCGTAAAACACATTAAGCGGTTCCCGCGGGAAACGATAGGACACCATAGGACCCGAATACTGACGATAGATACGAATAACGAATACTACATAGAACCGATAGGAAAACGATCGGAAACCGTAGAACACATTAAGGGGTTCCTGCGAGAAACGATAGGACACCATAGGATCCGAATACTGACGATAGATACAAATAAAGAATACTACATAGAACCGATGGGAAAACGATCGGAAACCGTAAAACACATTAAGCGGTTCCCGCGGGAAACGATAGGACACCATAGGACCCGAATACTGACGATAGATACGAATAACGAATACTACATAGAACCGATAGGAAAACGATCGGAAACCGTAGAACACATTAAGGGGTTCCTGCGAGAAACGATAGGACACCATAGGATCCGAATACTGACGATAGATACGAATAACGAATACTACATAGAACCGATAGGAAAACGATCGGAAACCGTAGAACACATTAAGGGGTTCCCGCGGGAAACGATAGGACACCATAGGACCCGAATACTGACGATAGATACGAATAACGAATACTACATAGAACCGATAGGAAAACGATCGGAAACCGTAGAACACATTAAGGGGTTCCTGCGAGAAACGATAGGACACCATAGGATCCGAATACTGACGATAGATACGAATAAAGAATACTACATAGAACCGATGGGAAAACGATCGGAAACTGTAGAACACATTGAAGGAAATCCCGCGAGAAACGATAGGACACCATAG
Protein Sequence: MGKRSETVKHIKRFPRETIGHHRTRILTIDTNNEYYIEPIGKRSETVEHIKGFLRETIGHHRIRILTIDTNKEYYIEPMGKRSETVKHIKRFPRETIGHHRTRILTIDTNNEYYIEPIGKRSETVEHIKGFLRETIGHHRIRILTIDTNNEYYIEPIGKRSETVEHIKGFPRETIGHHRTRILTIDTNNEYYIEPIGKRSETVEHIKGFLRETIGHHRIRILTIDTNKEYYIEPMGKRSETVEHIEGNPARNDRTP

Sequence clustering based on sequence similarity using MMseqs2