Basic Information

Gene Symbol
-
Assembly
GCA_947086465.1
Location
OX352256.1:4111829-4114431[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.03 1.9 9.4 0.5 2 23 75 97 74 97 0.96
2 15 0.05 3.2 8.7 0.2 5 23 127 145 123 145 0.91
3 15 0.00072 0.046 14.5 0.2 1 23 149 172 149 172 0.98
4 15 0.26 16 6.4 0.7 1 22 176 197 176 197 0.91
5 15 0.0039 0.25 12.2 0.7 3 23 253 274 252 274 0.96
6 15 0.38 25 5.9 0.1 2 23 299 321 298 321 0.92
7 15 0.15 9.8 7.1 0.7 3 23 346 366 345 366 0.97
8 15 0.00042 0.027 15.2 0.7 1 21 370 390 370 391 0.96
9 15 0.071 4.5 8.2 0.5 1 23 432 455 432 455 0.90
10 15 0.2 13 6.8 0.4 2 23 481 503 480 503 0.95
11 15 0.027 1.7 9.5 1.3 2 23 527 548 526 548 0.94
12 15 0.0018 0.11 13.2 0.0 1 23 552 575 552 575 0.97
13 15 0.39 25 5.9 0.4 1 23 579 602 579 602 0.97
14 15 0.002 0.13 13.1 2.8 1 23 641 664 641 664 0.97
15 15 0.00012 0.0076 16.9 1.9 1 23 674 697 674 697 0.95

Sequence Information

Coding Sequence
ATGACGAAAAGGAATGCTGAGATCGTGTTACAGTATTCCACGCTGTACCCATTCAGGTTGCGAGGGAAAATCTTAATCTGCGTATATTGCTGTGACGAATTCGACGAACCAGACCCATACCGATGCCATATGGACGAAAACCATAAGACTCCGATACTTTTTACTGCTTTTGCGCACACGGGGAGAAACCGAGATTACCTGAAAGTCGACTGCGTCAATCTCAAATGCAGATTATGTAATGCTTCGTTCGAAAACGTCAATCAAATCGCTAAGCACCTTAAAAGCACTCACAGTAACGATGATATCGAAAAACTGAATTTAAGCTACGAAGTGGCTTTACAACCGTACCGCTTAATAAAAGACAATTGGGTCTGCATAACTTGTAATACGAAGCTGCCTTCCTTAGCGAAGCTCCGCAGACATATGGCAACGCATTTCGCGGGCTACGTTTGTGATATTTGTGGCAGTAGCTATATTAAAGTTGACAGCTTGCAATATCACGTGAGATCAACACACTCTGGTAACTTCCCTTGCAGAAAATGCTGGAAGGTTTTCTTAACTAAAGAAGAAAAGAAACAGCACGCCAAAACTTCGCCGGCTTGGTCCAAATTGGAAATAAGAGGGCGTAGAAAGGGCGACACTGATGACAAAAAGAAAATAGTCCTTGTAAGCCAGACACCGCAAAGGCATAATGCCGTACTCATATTCAATCATTCCACCGCTTATCCGTTCAAAACACGATTCAGTCAGATTTTATGTGGTTTTTGCCATGAGGAATACAACACCCTGTCTGAACTCCGCTATCACATGTCTATCGATCACGTAAATCCTGATTACAGTAACATTTTTTACAGAATAAACGATAACTTGATTAAAGTCGATATTACAGACTTGAAATGTAAGATTTGTTCTTTGGCTATACCAGACATCGATACCCTGATGACTCATTTGGCACAGAAACACAAAAAACCTGTCAAGTTTGACGCGCGCTTTGGGGTTCTCCCTTATAAACTGAATGCAGACAATCAATGGTTATGTGTATATTGCCAGAGGAATTATACAGAGTTTATATCATTCAAACGCCATGTAGGAACGCATTTCATGAATTTCACTTGTGACAAATGTGGAACCAGTTTTGTATCTGATCGTGCGTTACGTGACCACCATCGCCAAGTGAAGTGCTTCAGAACCGCATACCATCCTCGTAATGGCAAAATCATGAGGTCGCGGAGCAACGCTGAGATACTCTTACAATGCTCCACCGTTTGCCCCTTTAGAACTTGGAAAAACAACTTTCATTGTGTATTTTGTCGTATTCAAACGAACGATCCGAGTAACCTGAGAATTCACGTGGCAGCGCGTCACGTGAACTATGATGTGCAAACGGCATTTTATAAGAAGCTCGGAAAAGATTTTTTGAGCGTAGACGTAACCGATATTCAATGTAAGCTTTGCTTTATCCCTCTATCAACCATAGATGCTCTAACTTACCACTTGAAACATGACCATCAACAACCCATCAACTTAGACGCACAATTAGGTTTGCTGCCATTCCGGCTTAACGATGGGTCCGTCTGGAAATGCACAATGTGCACAAATCAGTTCAAAGATTTTATATCTTTGAAGAAGCACACAGCTGATCATTTTCAAAACTATGTTTGTGATGCTTGTGGCGAAGGGTTCATCACGGAATCAGCGATGATAGCACACACGAAGATACCGCACGAAAATAAATACAATTGTAACAGATGTATAGCAACTTTTTCATCAGAGGAAGAGAGAAATATTCACGTAAAGACACAACACACTTCGATGCCGTATATGTGTATCTACTGCGCGGGTAAACCACGTTTTGCCAACTGGGAGCTGCGCAAAAAACACCTCATGGAAGTTCACAACTACAAGACTGGAGCTGATAAATACGAATGCACTGCCTGTCAGAAAACCTTCAAAACGCGATCAGGAAAATACAACCATATGACGAGAACTCACAAAATAAAGAAAGATGCAGAACTTAATTACCTATGTACAACTTGCCCGAAAGCATTCACAACTAAATTGTTTCTAGAAAAGCACATGACTAAAAAGCATTTCGATATTTAA
Protein Sequence
MTKRNAEIVLQYSTLYPFRLRGKILICVYCCDEFDEPDPYRCHMDENHKTPILFTAFAHTGRNRDYLKVDCVNLKCRLCNASFENVNQIAKHLKSTHSNDDIEKLNLSYEVALQPYRLIKDNWVCITCNTKLPSLAKLRRHMATHFAGYVCDICGSSYIKVDSLQYHVRSTHSGNFPCRKCWKVFLTKEEKKQHAKTSPAWSKLEIRGRRKGDTDDKKKIVLVSQTPQRHNAVLIFNHSTAYPFKTRFSQILCGFCHEEYNTLSELRYHMSIDHVNPDYSNIFYRINDNLIKVDITDLKCKICSLAIPDIDTLMTHLAQKHKKPVKFDARFGVLPYKLNADNQWLCVYCQRNYTEFISFKRHVGTHFMNFTCDKCGTSFVSDRALRDHHRQVKCFRTAYHPRNGKIMRSRSNAEILLQCSTVCPFRTWKNNFHCVFCRIQTNDPSNLRIHVAARHVNYDVQTAFYKKLGKDFLSVDVTDIQCKLCFIPLSTIDALTYHLKHDHQQPINLDAQLGLLPFRLNDGSVWKCTMCTNQFKDFISLKKHTADHFQNYVCDACGEGFITESAMIAHTKIPHENKYNCNRCIATFSSEEERNIHVKTQHTSMPYMCIYCAGKPRFANWELRKKHLMEVHNYKTGADKYECTACQKTFKTRSGKYNHMTRTHKIKKDAELNYLCTTCPKAFTTKLFLEKHMTKKHFDI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00661641;
80% Identity
-