Basic Information

Gene Symbol
-
Assembly
GCA_943735975.1
Location
CALSER010000059.1:590243-608460[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 8.6e-05 0.0051 17.4 2.2 1 23 416 438 416 438 0.97
2 20 0.0003 0.018 15.7 1.0 1 20 444 463 444 466 0.94
3 20 0.00023 0.014 16.1 5.6 1 23 485 507 485 507 0.98
4 20 0.0001 0.0061 17.2 4.1 1 23 513 535 513 535 0.99
5 20 4e-05 0.0023 18.5 5.3 1 23 541 563 541 563 0.97
6 20 5.7e-06 0.00033 21.2 8.4 1 23 569 591 569 591 0.97
7 20 2.5e-06 0.00015 22.3 3.0 1 23 597 619 597 619 0.97
8 20 0.00011 0.0064 17.1 6.7 1 23 625 647 625 647 0.97
9 20 2.1e-05 0.0012 19.4 6.4 1 23 653 675 653 675 0.98
10 20 5.2e-07 3.1e-05 24.4 1.9 1 23 681 703 681 703 0.98
11 20 5.3e-05 0.0031 18.1 7.9 1 23 709 731 709 731 0.98
12 20 0.00015 0.0087 16.7 6.6 1 23 737 759 737 759 0.97
13 20 4.4e-06 0.00026 21.5 5.6 1 23 765 787 765 787 0.98
14 20 1.9e-05 0.0011 19.5 6.7 1 23 793 815 793 815 0.97
15 20 1.2e-05 0.00069 20.2 5.2 1 23 821 843 821 843 0.98
16 20 2.1e-06 0.00012 22.5 3.6 2 23 850 871 849 871 0.98
17 20 1.9e-05 0.0011 19.5 8.1 1 23 877 899 877 899 0.97
18 20 1.8e-06 0.00011 22.7 6.5 1 23 905 927 905 927 0.98
19 20 0.00048 0.028 15.1 0.3 1 23 934 956 934 956 0.97
20 20 0.7 41 5.1 5.7 1 23 965 987 965 987 0.98

Sequence Information

Coding Sequence
ATGAATCCCGAGCATCATAATATCAATACGGGCGGGGGCCAACCTCCTGGGAGTTCAGAGTCTCAGAATCAAAGAATACAGGCTCAGCAGCAGCAGCAGCAAGTAAGCCTGCCTGCCACCACGTCTGCCACCGACTTGCGAGTCAACTCGGCAGCTGTGAACGTTGCTTTGTCCAGCGTTGCAAAGTACTGGGTGTTTACGAATTTATTCCCCGGACCTATTCCTCAAGTGTCCGTCTACGGGCTTCCAACTGGGACAAGAATTGAAAATGGAAAAGCTGTTCAGGATCTAGGACAAGCGCATGCTAGTATACTCAATGGGGATCCAAACATCATTCTGGGGCATCACGGAGGACAGTCCCAGGTCACAGTATCTGCCGCCCAACAGATACCCGTCTCCCAAATCATTGCCACACAGTCTGGGCAGACACATGAGTCATTGGTGGCACACAGTCAGCAGCAAGAGCTACAGGCTTCCAACCAGGTCACCACATCGCACCATCAGCAGGTACCCACTAACCGGGTCGAATTTGTCCAACACCATAACATTGATATGGGACATCATTCTCAACAACAACAACATCTAATGCAGCAGCAGCTTATGGCAGCGTCAAGGCCAGAACACTCAAACCAACAGATCCAACTGACGGTCAGTGAAGACGGCATCGTGACGGTAGTAGAGCCAGGCAGCAGTAAGATGGCGGAGAAGGAAGAGATGCATGAGACGATCAAGCTGCCAACGGATCATACGCTCACAGTGCATCAGTTGCAGCAGATTGTCGGCCAACAGGTTCTAGACAGCGTGGTTCGCATCGAGCAAGCGACCGGCGAACCCGCTAACATACTAGTCACCCACAACCCTGACGGCACCACGTCCATCGAGGCTAGCGCGAGCGATCCGCTTGCTATCGTCAAAGACGAGAAGATCCAAGGGAAGATTGAGACGACGCAGTTCGCTATACCGGCTGAGATTAAGGACATGAAGGGCATTGATTTGAAGGCCGTCAATGCCATGAACATGGAAGGCGCTGTAGTGAAGATATCAACGAGCGCGCCAGAGCACGATCTCCACGCCATGTACAAAGTAAATGTGGAGGATCTGTCGCAACTGCTGGCGTACCACGAAGTCTTCGGGAAAATGGGGCCGGATGGACAGCCTCAGGCTAAAGTTTCTGTTGGCGATGTAGAAATAGAAGTGCCTGGAACTAGTTCCGGTATGTCCGAAGCGGAGAACTCGCCGGGACACCATTCCTGTGACATCTGCGGGAAAATATTCCAATTCCGGTATCAGCTTATAGTACACAGACGTTACCACGGCGAGACCAAGCCATTCACATGCCAAGTTTGCGGCACCTCATTCGCGAACCCCGTAGAACTATCCCGGCACGGAAAGTGCCATTTGGCAGGTGACCCGGCTGAAAGACACGCAAAGAGAATGGCCCAAGACAAACCTTATGCATGCTCCACTTGTCATAAAACATTCTTGCGTAAGGAGCACCTAAACAACCACATACGCAGTCACACGGGAGAAACTCCATACAGATGCGAGTTCTGCGCCAAAACATTCACCCGGAAAGAGCACATGGTGAATCACGTGCGAAAACATACGGGCGAGACGCCACATCGCTGTGATATCTGCAAGAAGAGCTTTACGCGGAAGGAGCATTTCATGAACCATGTTATGTGGCACACAGGTGAAACGCCGCACCATTGTACGATTTGTGGGAAGAAATATACTAGAAAGGAACATTTGACGAATCATATGAGATCGCACACGAACGATACTCCGTTCCGCTGTGAACAGTGCGGGAAATCCTTCACAAGAAAAGAGCATTACTCCAATCACATTTTGTGGCACACTGGCGAAACCCCTCACCGCTGCGACTTCTGTTCTAAAACCTTTACTCGCAAGGAGCATCTCCTCAACCATGTGAGACAACACACGGGAGAGTCGCCGCATCGCTGCAACTACTGCTCCAAGTCGTTCACGCGCCGCGAGCACCTCGTGAACCACGTCCGGCAACACACGGGAGAGACGCCCTTCCAATGCGGATACTGTCCTAAAGCCTTTACTAGGAAAGACCATTTAGTAAACCACGTTCGACAACACACCGGTGAATCTCCCCACAAGTGCTCGTTCTGCACGAAATCCTTCACTCGCAAGGAGCACCTCACGAACCACGTGAGGCAACACACGGGCGAGTCTCCCCATCGGTGTTCATTCTGCGCGAAGTCTTTTACGAGGAAAGAACATCTTACCAATCACGTCAGACAGCATACGGGCGAAACGCCACACAAGTGCACGTATTGCCCGCGCGCGTTTTCGAGAAAGGAGCATCTGAACTCTCACCTGCGGCAGCACACGGGCGTCACTCCGCACTCCTGCTCTTACTGTAGCAAGACCTTCACGAGGAAAGAGCATCTTGTCAACCACGTACGGAAACACACCGGCGAAACACCGTTCAAGTGCACGTTCTGTTCGAAGTCATTTTCGCGCAAGGAGCATCTAACGAATCACGTAAATCTTCACACGGGGGAGACGCCGAACAAATGTCCATTCTGCACTAAATCCTTCTCTAGGAAGGAACATCTTACGAACCATGTCAGAATACACACAGGCGAGTCGCCGCACCGCTGTGATTTCTGCCAGAAAACGTTCACTCGCAAGGAACATTTGACGAACCATATGAAGCAGCACACGGGTGGCGCTGCTCACACGTGTAAGATTTGCCAGAAACCTTTCACGAGGAAAGAACATCTACAGACGCATATGAGATACCACAGTTGTAGCGACCGGCCGTTCAGCTGTGGAGAATGCGGCAAATCCTTCCCGCTGAAGGGTAATCTCATGTTCCACGAGCGGTCCCACAACAAATCCGGAGGCCCAAGGCCTTTCCGTTGTGATGTCTGTTCCAAGGACTTTTTGTGCAAATCTCATTTGCTAACTCACCGGCGAGTACACGAGGACGCCTGCGACGAAGTCTCTGTAGAGACTCAGACTGAGAATGAAGAGTGCTTGGCAGTCACCACAGATAGCACCAATAAAGGAATCAAGGTGGAGCTTGACACGCCAGATCAAAGAACTTCTGTAGAAAATGGACCAACTGAAACGATTACAGTGCAGCCTGCAATCAATTCCCCGAACCACATAGTAGTCACTCAAAACACTGTGATGCAGATAAGCAGTCAACAGGTACGAGTAGGTTCATCAAGTCCAACTGGTGTAACCACAGGCACTTTCACCCACACAGTGAGCGCACAGCACCACCCAGGTTCCACAATCGCGCACCACCCAGTTACAGTGAACTACTAG
Protein Sequence
MNPEHHNINTGGGQPPGSSESQNQRIQAQQQQQQVSLPATTSATDLRVNSAAVNVALSSVAKYWVFTNLFPGPIPQVSVYGLPTGTRIENGKAVQDLGQAHASILNGDPNIILGHHGGQSQVTVSAAQQIPVSQIIATQSGQTHESLVAHSQQQELQASNQVTTSHHQQVPTNRVEFVQHHNIDMGHHSQQQQHLMQQQLMAASRPEHSNQQIQLTVSEDGIVTVVEPGSSKMAEKEEMHETIKLPTDHTLTVHQLQQIVGQQVLDSVVRIEQATGEPANILVTHNPDGTTSIEASASDPLAIVKDEKIQGKIETTQFAIPAEIKDMKGIDLKAVNAMNMEGAVVKISTSAPEHDLHAMYKVNVEDLSQLLAYHEVFGKMGPDGQPQAKVSVGDVEIEVPGTSSGMSEAENSPGHHSCDICGKIFQFRYQLIVHRRYHGETKPFTCQVCGTSFANPVELSRHGKCHLAGDPAERHAKRMAQDKPYACSTCHKTFLRKEHLNNHIRSHTGETPYRCEFCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHFMNHVMWHTGETPHHCTICGKKYTRKEHLTNHMRSHTNDTPFRCEQCGKSFTRKEHYSNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCNYCSKSFTRREHLVNHVRQHTGETPFQCGYCPKAFTRKDHLVNHVRQHTGESPHKCSFCTKSFTRKEHLTNHVRQHTGESPHRCSFCAKSFTRKEHLTNHVRQHTGETPHKCTYCPRAFSRKEHLNSHLRQHTGVTPHSCSYCSKTFTRKEHLVNHVRKHTGETPFKCTFCSKSFSRKEHLTNHVNLHTGETPNKCPFCTKSFSRKEHLTNHVRIHTGESPHRCDFCQKTFTRKEHLTNHMKQHTGGAAHTCKICQKPFTRKEHLQTHMRYHSCSDRPFSCGECGKSFPLKGNLMFHERSHNKSGGPRPFRCDVCSKDFLCKSHLLTHRRVHEDACDEVSVETQTENEECLAVTTDSTNKGIKVELDTPDQRTSVENGPTETITVQPAINSPNHIVVTQNTVMQISSQQVRVGSSSPTGVTTGTFTHTVSAQHHPGSTIAHHPVTVNY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00704247;
90% Identity
iTF_00701278;
80% Identity
-