Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.4e-100 1.3e-95 322.2 29.5 20 300 1 279 1 279 0.96

2 3 0.0071 2.8e+02 2.7 2.8 122 171 279 328 277 332 0.91

3 3 0.064 2.5e+03 -0.5 5.5 193 238 309 353 291 354 0.60

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.4e-100	1.3e-95	322.2	29.5	20	300	1	279	1	279	0.96
2	3	0.0071	2.8e+02	2.7	2.8	122	171	279	328	277	332	0.91
3	3	0.064	2.5e+03	-0.5	5.5	193	238	309	353	291	354	0.60

Coding Sequence: ATGAGAGAATTAGAGAGGCAACAAAAAGAAGCAGAGGAAAATGCGGATAGAGTATTCGATATGTGCACAGCGGATGCTAACAGAGCTATGCGTGTAACACCAGATCCCATTCGTGCTTCTCGTCTTCTtgcaaatacaaataattttcaatcaagtCGAAGATCTTCTGAAGATTCTTTAGAAGAAGCTGGGCTTGGAAGAGATCTTCgattagaaCTAAaggaatttgaagaaaaatttagaaaagcaaTGATAGCAAATGCTCAGCTAGATAATGAAAAGTCTTCCTATGCATATCAAGTTGATTTATTGAAAGATAAGTTAGAGGAGCTTGAAGAAGTGACGGCTCAATTACGACGTGAACTCAGGGAAAAGAATCGTGAAGCAGATCAGTCTAAACGTCTTAGTCAAAGATTAAAAGAAGATTTAGATATTTGTAGAGCACAGCTTCAAGAAAGAGACACTCTAATTCAGGAAAATGGACTGGTCATTGTGGAAGATGAAGGCAGTGAAAATGAAGAAACACAAAAAGAAAACGGTCCTGTTTATCGAAAAAGAGTGCTAGTCAGTACAGAAGCTGcagaattattacaaaatgcTGGAGAAGGTTCATTAGatGTCCGACTGAGAAAGTTTGCATCAGAAAAGAAAGAATTACAAGATGAGATTAGGCATCTCAGGTTAGAATTAGAGGAAGCGAGGAATCGAATGAGGCCCGAGCGATCTTCAGGTTCTGTGCttgGCTTATCCGATTCAGAAGATGCTCAAAGGGAAGCTAATAAACTTTTGGcagattataaatttaaaatacaaaaagcaGAACAAGATATGTCAACTCTTCAAGCAACTGTGGCCAGGCTAGAAAGTCAAGTAATTCGTTATAAGTCAGCAGCTGAGGCCTCTGAAAAAGCAGAGGATGAGTTAAAGGTTGAAAAAAGGAAGTTGCAAAGAGagGTAAGAGAATCACAAGGTCGAGTGGAGGAACTGGAAACAGCAAATTCTCATTTGCAGCGACGCCTGGACAAGCTGAAAAATGCTAAGTCAGcccttttaaaagaactttga
Protein Sequence: MRELERQQKEAEENADRVFDMCTADANRAMRVTPDPIRASRLLANTNNFQSSRRSSEDSLEEAGLGRDLRLELKEFEEKFRKAMIANAQLDNEKSSYAYQVDLLKDKLEELEEVTAQLRRELREKNREADQSKRLSQRLKEDLDICRAQLQERDTLIQENGLVIVEDEGSENEETQKENGPVYRKRVLVSTEAAELLQNAGEGSLDVRLRKFASEKKELQDEIRHLRLELEEARNRMRPERSSGSVLGLSDSEDAQREANKLLADYKFKIQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRESQGRVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2