Edil009839.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Euglossa dilemma
Gene Symbol
egg
Assembly
GCA_002201625.1
Location
NIJG01000013.1:4304749-4310515[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.7e-14 2.4e-10 39.7 0.1 5 70 618 677 615 683 0.88

Sequence Information

Coding Sequence
ATGGAAGTTATTGAACTTGTTTCTGATGATGAAATATCAGAAGACAACACAAAAGAAAATAGAAGTTCAAAAATTTGTAATACTAATTGTATAAACTTTCAATGTTCTTCTGGCGTGGATATGAAATTAGCACCTTCTTTCGCATGTGCTTTTTATGGAGTAAATACAGAAAAAAAGAAAGAACGTATGATATGTCGAAAGTGTTTTAATGCTGCTTTAGAACATCAAAAGCAACTGGTCACAGCTTTTGTGGATCATAAGCCATTATTAAAATGTGAATTTCCAGACCATACAATGGAGGTAGAAATTTCTGATAGTGATGATTCAGATGAGGAAAAAAAGAAAGATATATATAATGAGGAAAAATATTTACCAGAAGAAATGCTTAAGGATATAGAGGAAATGTTAGATTACACATTAAATAGTATCTTTAAAAAGTATGATGTTGATTATCAAATTAAGCAAGCCCATAATATACTAAAAGATCGATGGGATAAATTAGATGAGCAAAATGACGTTCTGGATAAAACAGTCAAAGGCTTAATGCGTACTATGGATACATTACGCAATAATTTATATGATGAATTCAGACCACAAATTCAAATGCGGCAAGAGATTCAAATAGATGATGGATATGTAGACAATATTCTTTACCCATTAGTGGCAACAAAAAAAGTTACACAAATAAGAGTTCCTCCATCTTCGATGTTACAAGATAGTCAACCAGAAATTTTACCAATTGAACAAGATAATAGACAAGTTGTGGTTTTGGATTTACCTCCAATTGGTCCAATTGTGAGAGCACAAATAGATGTAGATAGCATTGTATATATTATGAAACATCCACTTATGCCATGGATTAAAGGAAAGGTGCAAACTATACTTTTAAGAACTCCTTTGCATTGTCGTGTAAAATTATTACAAAAAAAGTATAATTCTGTAATTAAATCAGTTTCTGGTAAGCAAATAGCAGCTGCTGTAACTAGTCAAGTAATAATTCCAGTTGGTACACGAGTAGTTGCAGTATTTAAAGATGTTTCATCTAGTAATTTCTACAGTGGAGTTATAGCTGAACCACCAAAAGCTACAAATAAATATAGATATTTAATATTCTTTGATGATGGATATGCTCAATATGTTGAGCATAAACATATTTATTTGGTCGCTGAATCTTCATCTAAAGTTTGGGAAGATATACCTAATGAATCTCGTGATTTTGTGAAAAAATATATTGAAACATATCCTGAAAGACCAATGGTAAAATTGCAAACAGGACAAGTAGTAAAAACGGAATGGAATGGTAAATGGTGGATTGCAAGAGTAGTTCAACTTGATGCAAGTTTAGTACAGATGCATTTTGATGCTGATGGAAGAACAGAATGGATCTACAGAGGTTCTGCTAGATTAGGTCCTCTATATCTTGAACTTTTAAAAGCCAACGCTAGGCAACAAGGACATCATGCATCTGTTAATACTCCGAGTCGACATCGATTACCTGTTGTTTCTAATAAAAGTAATTTACCTTATGTAGAATATACGTCTAATATAGAATCTGAAGAAGAAAGACTTTCTCAATTAGAAAAAGAACAGAATACAGTAAATGAAACTACAAATACATTTACGTCAAATGTACCGCAGCAATCACGTGCTGTTGCTAGAAAAAGTACAAGTAAAAAGCAAAATATTGTGGATACAAGTCCCTATAATCCTACAACAGAAACAAAACCTTCTCATAGCATTGTTTATTATCAAACACAGAACAAAATTCAAACAAAGAAATTTGTAACACATAATTGTGGTCCTCAGTGTGTTCAAGGAATATCCTTTACACCTGATGATTTAAGAGGTTATTCACCTCTTTCAATACCATTACTTTGTGGTTGGAATAGACAACTTTGTAAATATCCAAAAGGCAAAAAAATTACACTATATCAAGCTCCATGTGGTGTCAGATTACGAAATATGGAAGAGTTACATCAGTATCTTCGCAAAACAGGTAGTCCAATGTCAGTTGATTTATTCGATTTTGATTACTGGGTGCATTGTCTAGCAGAATTTGTTCTGGATAAGTGCTTTATCAATATAAAGGACCTTAGTTATGGTGTAGAAAATGTACCAATACCATGCGTTAATGAATTAGATCACACTCAACCAGATACCATTAGGTATAGCACTCAAAGAGAACCAACAGAAGGAGTTAATCTTAATTTAGATCCCAATTTTCTGTGTAGTTGTGATTGTGAAGATGATTGTCAAGACAAAACAAAATGTCAGTGTTGGCAATTAACAGTACAAGGTGCTACTCTTGGAGGAAGAGTACCAAATACATCTGTGGGTTATGTATATAAACGTTTGCCAGAGCCAGTTACAACTGGAATTTATGAATGCAATTCTGGGTGTAAATGTGCTATAAAAACTTGTTTGAACAGAGTGGTTCAACATCCACTAACATTGAAATTACAAGTGTTTAAAACAGCTCCTCGAGGCTGGGGTATACGATGTCTAAATGATATTCCTCTTGGATCTTTTATTTGTATATATGCTGGTAGACTACTTACAGAGCAGGGTGCTAATGAAGGTGGTAAAAACTATGGAGATGAATATTTAGCTGAGTTAGATTATGTAGAAGTAGTAGAAAGTATTAAGGAAGGTTATGAAAGTGATGTTCTTGAACCAGAAATGCCATTATCTACACCAGAAGATAAAAAGAAATCAGTGACGAGTGACGATGAAGATAATACGAAAACAAATGCAAATGATTCGGACGAAGATTTTAATATTAGTAAATACGTGAACTTTAATGTAGATTCTACAGAACCATCTTCCATTAGGAAAAGGTTAAGAAAACGAAAACGAGATGATGCTAATCAAGATGGATCTGAAGAAAATAGCGAAGATGGAAGCGCTACTAAAATTTCCGAAAACATTGCAAAATCTTCTACTAATGAAAATCGGTCGAATGATCAAGATGCAATTACTATAAGTGATGAAGAAGAAAATAGAAGCGGTAGACGTGAACCAAGTAGATTTGATCCAACAGTAGAACCAACACAGATAGAAAGACCTAAATTTAAATCAGTAAGAGATTTCTTTGGAGAAGATGAAGCTGTTTACATAATGGATGCTAAAACAACTGGAAATATTGGACGTTACTTAAACCATTCATGTGATCCAAATGTTTTTGTACAAAATGTATTTGTTGATACACATGATGTAAGATTTCCATGGGTGGCATTCTTTGCTTTAAATTATATAAGAGCTGGTCAAGAATTAACATGGAATTACAGTTATGATGTTGGAAGTATACCAGGTAAAGTTATCATATGTAAGTGTGGTGCATCTAATTGCAGAGGTCGACTTNN
Protein Sequence
MEVIELVSDDEISEDNTKENRSSKICNTNCINFQCSSGVDMKLAPSFACAFYGVNTEKKKERMICRKCFNAALEHQKQLVTAFVDHKPLLKCEFPDHTMEVEISDSDDSDEEKKKDIYNEEKYLPEEMLKDIEEMLDYTLNSIFKKYDVDYQIKQAHNILKDRWDKLDEQNDVLDKTVKGLMRTMDTLRNNLYDEFRPQIQMRQEIQIDDGYVDNILYPLVATKKVTQIRVPPSSMLQDSQPEILPIEQDNRQVVVLDLPPIGPIVRAQIDVDSIVYIMKHPLMPWIKGKVQTILLRTPLHCRVKLLQKKYNSVIKSVSGKQIAAAVTSQVIIPVGTRVVAVFKDVSSSNFYSGVIAEPPKATNKYRYLIFFDDGYAQYVEHKHIYLVAESSSKVWEDIPNESRDFVKKYIETYPERPMVKLQTGQVVKTEWNGKWWIARVVQLDASLVQMHFDADGRTEWIYRGSARLGPLYLELLKANARQQGHHASVNTPSRHRLPVVSNKSNLPYVEYTSNIESEEERLSQLEKEQNTVNETTNTFTSNVPQQSRAVARKSTSKKQNIVDTSPYNPTTETKPSHSIVYYQTQNKIQTKKFVTHNCGPQCVQGISFTPDDLRGYSPLSIPLLCGWNRQLCKYPKGKKITLYQAPCGVRLRNMEELHQYLRKTGSPMSVDLFDFDYWVHCLAEFVLDKCFINIKDLSYGVENVPIPCVNELDHTQPDTIRYSTQREPTEGVNLNLDPNFLCSCDCEDDCQDKTKCQCWQLTVQGATLGGRVPNTSVGYVYKRLPEPVTTGIYECNSGCKCAIKTCLNRVVQHPLTLKLQVFKTAPRGWGIRCLNDIPLGSFICIYAGRLLTEQGANEGGKNYGDEYLAELDYVEVVESIKEGYESDVLEPEMPLSTPEDKKKSVTSDDEDNTKTNANDSDEDFNISKYVNFNVDSTEPSSIRKRLRKRKRDDANQDGSEENSEDGSATKISENIAKSSTNENRSNDQDAITISDEEENRSGRREPSRFDPTVEPTQIERPKFKSVRDFFGEDEAVYIMDAKTTGNIGRYLNHSCDPNVFVQNVFVDTHDVRFPWVAFFALNYIRAGQELTWNYSYDVGSIPGKVIICKCGASNCRGRL