Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.015 10 7.7 0.0 22 52 6 36 3 37 0.89

2 9 0.011 7.3 8.1 0.0 20 47 60 87 49 93 0.82

3 9 0.0041 2.8 9.4 0.0 21 46 117 142 108 150 0.85

4 9 2.2 1.5e+03 0.7 0.0 21 48 145 172 141 176 0.82

5 9 0.079 53 5.3 0.0 22 48 174 200 165 204 0.86

6 9 0.0021 1.5 10.3 0.1 22 52 202 232 197 234 0.87

7 9 0.0083 5.6 8.5 0.1 21 52 257 288 249 290 0.86

8 9 0.4 2.7e+02 3.1 0.1 22 46 286 310 281 316 0.84

9 9 0.51 3.5e+02 2.7 0.0 21 44 313 336 307 340 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.015	10	7.7	0.0	22	52	6	36	3	37	0.89
2	9	0.011	7.3	8.1	0.0	20	47	60	87	49	93	0.82
3	9	0.0041	2.8	9.4	0.0	21	46	117	142	108	150	0.85
4	9	2.2	1.5e+03	0.7	0.0	21	48	145	172	141	176	0.82
5	9	0.079	53	5.3	0.0	22	48	174	200	165	204	0.86
6	9	0.0021	1.5	10.3	0.1	22	52	202	232	197	234	0.87
7	9	0.0083	5.6	8.5	0.1	21	52	257	288	249	290	0.86
8	9	0.4	2.7e+02	3.1	0.1	22	46	286	310	281	316	0.84
9	9	0.51	3.5e+02	2.7	0.0	21	44	313	336	307	340	0.88

Coding Sequence: ATGAATCACACTGGTGATAAACCTTTCACatgtgtagtgtgtgataaaacattctcacaatTAGGAACTTTAACAAGGCACATGAGACTCCATGCTGGTGATAAACCATTCAAATGTATTAAGTGTGATGGAACATTCTCACAATTAGGTACCTTAACAAAgcacatgagaactcacactggtgagaaaccatacacaTGTATAGAGTGTGATAAAAACTTCTCACAATCATCAAACTTAACAATGCACATGAGATATCACACTGGTGATAAACCATTCAAATGTATTGAGTGTGATGGAACATTCTCACAATTAGCTAACTTAACAAGccacatgagaactcacactggtgagaaaccatacacatgtgtagagtgtgataaaacattttcacaatccCATAACTTAACAAGccacatgagaactcacactggtgagaaaccatataaatgtggaTTGTGTGATAGAACATTCTCACATTTAGGAAACTTAACAacgcacatgagaattcacactggtgataaaCCTTTCGCatgtgtagtgtgtgataaaacattttctaattccTCAAGCTTAAGAAcccacatgagaattcacactggtgataaacctttcacatgtgtagtgtgtgataaaacattttcacaatcctCACACTTAAGAAtccacatgagaattcacactggtgacaaaccatacaaatgtgtaaaGTGTAAAAAAGATTTCTCATTTTACTCAGCATTAAGACgtcacatgaggactcacactggtgagaaaccatacacaTGTATAGAGTGTGATAAAAACTTCTCACAATCATCAAACTTAACAatgcacatgagaattcacactggtgataaaccatacaaatgtattaAGTGTGACAGAACATTCTCACAATCATCAAACTTAACAGCgcacatgagaactcacactggtgagaaaccattcaaatgtgtagAGTGTAAAAAAGATTTCTCAGTTTCCTCAGCATTAAGACGTCACATGatgactcacactggtgagaagtaa
Protein Sequence: MNHTGDKPFTCVVCDKTFSQLGTLTRHMRLHAGDKPFKCIKCDGTFSQLGTLTKHMRTHTGEKPYTCIECDKNFSQSSNLTMHMRYHTGDKPFKCIECDGTFSQLANLTSHMRTHTGEKPYTCVECDKTFSQSHNLTSHMRTHTGEKPYKCGLCDRTFSHLGNLTTHMRIHTGDKPFACVVCDKTFSNSSSLRTHMRIHTGDKPFTCVVCDKTFSQSSHLRIHMRIHTGDKPYKCVKCKKDFSFYSALRRHMRTHTGEKPYTCIECDKNFSQSSNLTMHMRIHTGDKPYKCIKCDRTFSQSSNLTAHMRTHTGEKPFKCVECKKDFSVSSALRRHMMTHTGEK

Sequence clustering based on sequence similarity using MMseqs2