Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.9e-22 3.2e-18 65.6 0.0 1 65 53 119 53 119 0.93

2 2 1.1e-17 9.2e-14 51.4 0.1 1 64 154 244 154 245 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.9e-22	3.2e-18	65.6	0.0	1	65	53	119	53	119	0.93
2	2	1.1e-17	9.2e-14	51.4	0.1	1	64	154	244	154	245	0.91

Coding Sequence: ATGTATGAAGATGGGAACATTACTTGTACCCCCAAGCGCTGCGTGCTCACTGAAGTCACAAACTCTGCCAGCTATGTGTCTCCGACTGCCAACCTCAAATTGTTGACTAATGTCGCACTGCAGTACCCCACGCCGCCGCCTAGTGCAGTACACCGCAAAGAGAAGTCTCTGCAGATACTGTGCGACAGATTTCTTAACCTGTACCCTCTTATTGGAAAAGGTACGGTTGAGATTCAATTGGATGGCACTGCAGCCCGGTTAGGCGTTGAGAAGCGTCGAATGTACGACATTATTAATATTCTAGAAGCTATGCAGTGTGCGGTTCACAAAAGAAAGAATACTTACCTCTGGCATGGAGGCTCAAGACTGAATTCCTTCCTGAAGATGCTTAAGAAGCAAGGAGAGAACCTGAGGTTATCGGATGCGCTACGAGGACGAGCTCCCAAGCCTCCCGCTCCAAAACATAAAACACTGGGAGTCTTGGCTCAAAGATTTTTAATGTTATTCTTAGTGGAAAAGCCTAATACTCTTATAAACCTGGAGATGGCGGTTGGTGTACTCATAGACACATCAGACAAGAATAAAACGGCTCTGTCACCTGAGCAACAGGAACGTCAGCACAAGTCCAAAGTGCGTCGCCTTTATGACATTGCCAATGTGTTAATTTCAATTGGTCTCATAGAAAAAGTGTCAGGTAATTTAATTTTAAAGAAGCCTGTGTTTAGATATGTGGGGCCTTTTAAAATGAGGAAGTCTGGCAAGGTTACGGTGGCTGCCCCATCTCCAATAACTCCACTTTCAGTCATGAATATTCAGCAGAAGACTTCTCCAAATAACATGTTTGCTGGGAGGTCAAAAAGAAAGCTAGAGTTCACTACACCAAGTTCTAGCAAAACTTTGAAAATGGGTATCACCACTCCTCCTCACACTCCGTCGCACAAGTGGGATGAGATCCTGCTTGTCGCTGACATGGAACTGACTAGAATTAACAATGGCATGTGA
Protein Sequence: MYEDGNITCTPKRCVLTEVTNSASYVSPTANLKLLTNVALQYPTPPPSAVHRKEKSLQILCDRFLNLYPLIGKGTVEIQLDGTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKMLKKQGENLRLSDALRGRAPKPPAPKHKTLGVLAQRFLMLFLVEKPNTLINLEMAVGVLIDTSDKNKTALSPEQQERQHKSKVRRLYDIANVLISIGLIEKVSGNLILKKPVFRYVGPFKMRKSGKVTVAAPSPITPLSVMNIQQKTSPNNMFAGRSKRKLEFTTPSSSKTLKMGITTPPHTPSHKWDEILLVADMELTRINNGM

Sequence clustering based on sequence similarity using MMseqs2