Basic Information

Gene Symbol
RREB1
Assembly
GCA_944738805.1
Location
CALYJE010000007.1:814846-820691[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.024 2.6 8.8 0.8 1 21 235 255 235 257 0.93
2 14 0.00022 0.024 15.2 0.2 1 23 267 289 267 289 0.98
3 14 6.3e-06 0.00069 20.0 5.2 1 23 295 317 295 317 0.98
4 14 0.009 0.97 10.1 1.4 2 19 536 553 536 553 0.97
5 14 3.1 3.3e+02 2.1 0.6 1 19 599 617 599 619 0.78
6 14 0.0059 0.64 10.7 0.1 1 23 772 794 772 794 0.97
7 14 0.00012 0.013 16.0 1.7 1 23 803 825 803 825 0.99
8 14 0.00021 0.023 15.2 2.1 1 23 831 854 831 854 0.97
9 14 0.00063 0.068 13.7 2.1 1 23 1195 1218 1195 1218 0.95
10 14 5.7e-05 0.0062 17.0 0.3 2 23 1520 1541 1519 1541 0.97
11 14 0.096 10 6.9 6.3 1 23 1547 1570 1547 1570 0.97
12 14 3.6 3.9e+02 1.9 5.3 1 23 1676 1698 1676 1699 0.93
13 14 0.0056 0.61 10.8 0.5 3 23 1748 1768 1746 1768 0.96
14 14 0.00092 0.1 13.2 4.8 1 23 1774 1796 1774 1796 0.99

Sequence Information

Coding Sequence
ATGCTAAAGACATCAATCAAAAAGCAATTAACAGACATTCCAATGCAGAAAATGGACCGACGCGAATCGACAACGTCGAATTCATCGATTGAGCCCATGGATTTGGGGCGCGCACAATCGGCAATCTGTGCGGACATAAAAAAAGAGACCAACACAGCATTACAATTGCAAAACCTGAAACTTATGGATGCCATTTTATCAGATGCCAATATGAAGCTGAACGCCAGTCATGAGTCCGATGGGGACGAATCGGACGATCGCGATCACCGGGATCAGCGCAGGCGATCGCATAGTCAACATCACTACCATCATCGCCGGCGTGGCGGCAACAGTGGCCGCGACAAGCGCACCGTTCACCTGGAGTGCACCGACAGTCCGCACTCTCTGCGGAAGAAGTTCCGTTTCAGCAGCAACCAAAACATTCCAGAGTCTGTGATCAACTTGAAGCAGAAGACATCGAACAACGACTCAAAGTCATCGGCCACAGCCAATCTGACAGCCACAACGAACAACAACGAGTCGGGCTTCGTGGATGCGAGCAGCAGCCACGTCTTGAACACCTCTGCCTCGTCGGCCGCATCGTCCGGATCGTCATCCTCATCGTCACCCACCTCGTCGACGTCTGCCTCCCCATCCGCCAGCAACATTGCATCGGTCGTCTCCAGCCCCGAGTCGGGCATGGGTGAACGTGACGACATGAAGTACCTTTGCCCAATTTGTGAAGTTGTGTCGGCGACACCGCATGAATTTACCAATCACATTCGATGTCATAATTATTCATCTGGGGACACCGAAAATTTCACCTGCCGCATTTGCTCTAAGGTTCTGTCATCAGCCTCGTCGCTGGATCGGCACGTTTTAGTGCACACTGGCGAGCGACCTTTTAACTGCAAATATTGCCAGCTGACATTCACCACTAACGGCAATATGCACCGCCACATGCGTACACACAAGCAGCACCAGCAACACTATCACCGGAATTCGAACGGCACGAAGGGTGGAGGTGGCAGTGGAACCAGTGGCGGTGGTGGTGGTGGTGTTAGTGGTGGTGGTGGCAGTGCGGGCAATGGCGGCACCTCCAGCATGAATCCAGTTTTACCGTCAAGCGACCAGCAATTGGCTGGAGCTTCAAGCACAGCGACAGGCGGCTCGATGCCCTCCAAAACGTCAAACGTCAGCAACGGTGTGGCTGTTAATGGCAATGGCGACACTGTGACGGGAGGAGGTGGTGGTGGTGGCGGCGAAAGCTACGAAAGTGATGGTGGTTGCTCAACGGATTCATCAAGTGCCATCAGCCAGAGTTCCAATAACAACAACAACAACCACAATACGAACAATAAAAACATTTGCAATTTTAAGCGCAAGAGCACCGACAGCGTGGACGACATGGCCGTGATGAAGCGACGCCTGAAGACCACCATCAACAACAACAACATCATCGATAATGCGCACGCCGAGAAGGGCATAATCGAAGAGGCCGATGTTATCGACGATGTGAAGCAACAGCAGCAGAAGCTCTTCTGTCCGGTGTGCAATCGCAACGACTTTGGGGGAATGCTGGCGCTGGACGCGCACATGGACTGCGATCACTCGGACATCCCGGCGAAGTGCCGCTACTGCGACGTGGTGTTCAAGACCCACAAGCAGTTGAACGTGCACCCGTGTACCAGCAAGCAGAAGACCACACCCGGCTTCAAAGATCTTACATTTGTGGACTTCTCTAGCGAGAAGTTCCCGCTCATCGCTAAGTCTGTGTGTGAGCAGAGCCTGCGAACGTCGGTGTCGAGTCAGAAGTTTGAGTGCTCCAAGTGCTACAGGGCATTCCCGTGTGCCAGTGCGGTTGAGATTCACGAGAAGGACTGTGCATCGTCCGGGAAAAATCTGAGTGTTGACGCCCACGACTTCTCCACTCGCAAACAGCGTACGTACAGCGAGAGTTCAGGAGGCTTGGACGACGACGAGACTGGACGGCGGGAGGAGTTCTTCGCACGACTGTACTTGAAAAACAAATCCACAGCACAAAGCATGACAAGCCTCTCGGCGTCTTCGCCCTCCCTGTCCGACGTCAAATCCTCCGAGCTGGACAAGACCCCCATAAAGATGTCGCAGTTCGAACAGTACCAGGACTCGAAGGAGCTCGCTGACATCCAGTCCATTCTAAACTTGACCTCGTCTTCATCGACAAGCAACTTTCTGCGCAACTTCGAGAATTCTGTCAACGCCCCCATTAGCAACTATGGCGCGGAGAATGGCGAGGAGGAGGCACAAGATGCGTTCACTTCGGAATTCCGTAAAATGAAGCTGCGCGGCGAGTTCCCGTGCAAGCTGTGCACGGCAGTGTTTCCAAATCTACGCGCACTCAAGGGGCACAATCGAATTCATCTCAGCGCCGCCGGCCCCGGCCCCTACCGCTGCAATATGTGCACGTATTCGATTCACGACAAAGCCGCCCTGGTTCGTCACATGCGCACTCACAATGGCGATCGACCGTACGAATGCGGCATCTGCAACTACGCTTTCACCACCAAAGCCAATTGCGAGCGACACCTTCGCAATCGTCATGCGAAGACCACTCGCGACGAGGTGAAACGAGCCATAATCTACCATCCGTCGGAAGACTCGAACTGCGACGACGCCATGAAGAAACTTCACATGTTCTCCTCACCGGAGTTCGACGACGACTTGGACCAGAACCACCCGCCCAAGGATCGCTCCACACCGGTGTCGCACTTGAAGGAGATGCTGCAGGCCGAATCAAAGCCACTCAAGATTCAGGTAAAAAGCTTGGAGAAACTCATTGACAAGGCTGCGGCGTCGTTCAGTCACTCCGACGAGGCCGACAACGAGAGCGAAGTTGTTGAGGCACAGCCAGAAAAATCAACTAGACCGATGGACCTCAGCATGGATGCCTTGGATCTGAGCAAGAAGCCGTTAAAGACGCCAAAGGTCGAGGAGAAAGCACCACAGTCCCCGAGTTTGCCGCAAACTCTCCCGTCCCGCATCTCCACCGACGAGCAGCACATCGACATCAGGACACTGGAGAAGAATCGCCAGCTTTTGCTCGAACAACAGCGGCTGCTAAGCGAAGCAATGTCCAAAATGAATCCTGCTCATTACCTGCAATTGACGGAGCTCTACAGAAACTTGGTGTTCCCGCCTCCCTTCTTCCTTCAGAACTCTTTCCTCTCCAACAACATCAACGATCAAAGCAAATTCGCGCCAATGATGAGCTCCCTCTTTGAGCACGCAGCTAACTCCCAGCCTCCGTCCTCCTTAACACCTACCAGCAACAACTCAACATTGCCGTCCAAGGCGGAGGAGAGTTCCTTGCTGTTGAAGCAGTCCAATTCACGGCCGCATTCGCCGACTCCCGCCAAGAGCCAGTTGCTGCCGAGAAACATCACCCCGTCGTCAACACAAATGCCTTTGATTCCCCGCAGTCATCACCATATGGGCGCCGCCTCGCACCCCTCGGCTATCCTTCCTTCATCAGTGGCCAATTCGGGACCGGTGAAGATGGTCATCAAGAACGGAGTCCTGATGCCGAAACAGAAACAGCGTCGTTACCGCACTGAGCGTCCATTTGCTTGTGAACACTGCTCAGCTCGGTTCACCTTGCGCTCAAACATGGAACGGCATATCAAACAACAGCATCCCCAGTACTGGGCACAGCGGCAACGCAGTGGACACCACATCATGCGTGGCCGCGCCAGTAGTTCGGTCCTATCCCACATGCAGTCGCCGCACCCACCCATGGAGGCGGCACATTCGATGGGCAGCGGTGGCATGATTTCGAACACACTCAGCGCCATCTCCGATCAAGTGAAGTACGCCATACTTGCCCAGCAGCTTAAGGCGCGCAAGGACACCGACATACTGCAGCAGGCCCTGTCGCAGGGTTCCAGCAGCGTTTTGGCGCAAAATCCTTCAGCCGCCATAAGTAATCTTCGAAAGTCGCTCAGCTCATCGTCCAACACGAACAACGGCAGCATAGAGGATGACGATCCGAAACTGGTCATCGACGAGGACGACGAGAAGGATGAGGAAGAGGATGAGGAGGAGGAAGAAGATCGCAAGCCCGATAATCTGAAACTGCATGAATTTCAAGAACAAAACACAATTGAAGCCGCCAAGAAGGTGGCCGAATCCATTCTGGAGCAGGCGATGAAGGCTGGCGGCACTAAGAATCCCTACAGCACCAACTCGGTCGATGAGGACCGTTCGCTCACCAAGGACTTTGGCCTCAAACTGTCCAACAACATGATTGCTCAAGCTGAGTCTGTGGGTAAGATACTAAAGGAAGTGGCCAGCTCTCGATTCAAGGACGAAAACAACGACCTCGCCTCAGTGTCTCGACTGGTCGACAACGCCACCAACTCGATGTCGTTCAATAGCTACTTTCGCAGCGATGTCGTGAACCAAATGGAGCAGAGCGACGAAGAGGGCTTAGTGGCCTCCGGTAGCGCATCAGAAAGCAATAACTCAGGGCCAGAGGACATGGCCGGCTCACAAGAACCCAAGAAAAAGTCCGCTTACAGCTCGGCCCCGAACCGAGTTTCGTGTCCGTACTGCCAGCGCATGTTCCCTTGGTCCAGCTCATTACGTCGTCATATCCTTACTCACACTGGCCAAAAACCCTTCAAATGCTCGCACTGTCCGCTGCTTTTCACAACCAAAAGCAACTGCGATCGCCACTTGCTGCGAAAGCACGGCAACGTCGAATCGGCCGTGTCTCTGTACGTCCCTATTGAAGATGTCAACGAACCGCTGCCTGTGCCGAAGTCTGTCGAAGAGATCGagctacagcagcagcaacaacttctgcagcagcaacagcaactccagcaacagaaaaagctggaGGAGCAAAAAGAATTCGAGAAGATTCAAACGCCTCCGCAAAAACCAACTGCTCCCACACCCGAGAATCCAGAGCCAGCAGTCAGCGCGAATTCAACGCCATCTGCGAATGTAGTCTGCAAGGTTGAGCCAATCCCACAGATAGTCTCGTCCTCTGAACTGCCATTCAAGTGTCATCTTTGCGACAGCTCGTTCGCGGAGCGGCTGCAATGCCTGGATCACATAAAAATCCACCATGCTCAAGAGTTTGCTCTTCTCCTGTCCAAGGGAGCGATTGACAACGAAGCCGACGTCAACAGCCAGGTCCAGTCAACAGAAGACGATGAGAAGCGCGACGAAAGCCGTGGAAAGTACCCGGACTACACCAACCGCAAGGTAATCTGCGCCTTCTGCGTACGTCGCTTCTGGTCGACCGAAGACCTGCGACGCCACATGCGCACCCACTCTGGAGAGCGCCCATTCCAGTGCGACATATGCTTGCGGAAGTTCACCCTGAAGCACAGCATGCTACGCCACATGAAAAAGCACAGCAACGGCGGGCATTCAGGTAACGGTGCGACAAATGCCAACAACAGCGGCTCCGACGATGACGACGACGAACAGCCACCCACAAGTATGAGTCTGGCCACAACCCTGCGCTCGCACACTATTCAAGAGATCTTTTCGAAAGCCACCAGTGAGTGGCGCAACAGTCGCCTATCGGGCGAGCACAAGGAGAACATCGAAGAGCACAACAACCAATCCGACCTAATCGGCAACTTGCTTGGCATCAGCGATCAAGGCATCCTCAACAAGCTTCTTTCGTCCGCTGACGAAGCCGCTAAATTCCTCGGCGTCGACAAGTGA
Protein Sequence
MLKTSIKKQLTDIPMQKMDRRESTTSNSSIEPMDLGRAQSAICADIKKETNTALQLQNLKLMDAILSDANMKLNASHESDGDESDDRDHRDQRRRSHSQHHYHHRRRGGNSGRDKRTVHLECTDSPHSLRKKFRFSSNQNIPESVINLKQKTSNNDSKSSATANLTATTNNNESGFVDASSSHVLNTSASSAASSGSSSSSSPTSSTSASPSASNIASVVSSPESGMGERDDMKYLCPICEVVSATPHEFTNHIRCHNYSSGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCKYCQLTFTTNGNMHRHMRTHKQHQQHYHRNSNGTKGGGGSGTSGGGGGGVSGGGGSAGNGGTSSMNPVLPSSDQQLAGASSTATGGSMPSKTSNVSNGVAVNGNGDTVTGGGGGGGGESYESDGGCSTDSSSAISQSSNNNNNNHNTNNKNICNFKRKSTDSVDDMAVMKRRLKTTINNNNIIDNAHAEKGIIEEADVIDDVKQQQQKLFCPVCNRNDFGGMLALDAHMDCDHSDIPAKCRYCDVVFKTHKQLNVHPCTSKQKTTPGFKDLTFVDFSSEKFPLIAKSVCEQSLRTSVSSQKFECSKCYRAFPCASAVEIHEKDCASSGKNLSVDAHDFSTRKQRTYSESSGGLDDDETGRREEFFARLYLKNKSTAQSMTSLSASSPSLSDVKSSELDKTPIKMSQFEQYQDSKELADIQSILNLTSSSSTSNFLRNFENSVNAPISNYGAENGEEEAQDAFTSEFRKMKLRGEFPCKLCTAVFPNLRALKGHNRIHLSAAGPGPYRCNMCTYSIHDKAALVRHMRTHNGDRPYECGICNYAFTTKANCERHLRNRHAKTTRDEVKRAIIYHPSEDSNCDDAMKKLHMFSSPEFDDDLDQNHPPKDRSTPVSHLKEMLQAESKPLKIQVKSLEKLIDKAAASFSHSDEADNESEVVEAQPEKSTRPMDLSMDALDLSKKPLKTPKVEEKAPQSPSLPQTLPSRISTDEQHIDIRTLEKNRQLLLEQQRLLSEAMSKMNPAHYLQLTELYRNLVFPPPFFLQNSFLSNNINDQSKFAPMMSSLFEHAANSQPPSSLTPTSNNSTLPSKAEESSLLLKQSNSRPHSPTPAKSQLLPRNITPSSTQMPLIPRSHHHMGAASHPSAILPSSVANSGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHIKQQHPQYWAQRQRSGHHIMRGRASSSVLSHMQSPHPPMEAAHSMGSGGMISNTLSAISDQVKYAILAQQLKARKDTDILQQALSQGSSSVLAQNPSAAISNLRKSLSSSSNTNNGSIEDDDPKLVIDEDDEKDEEEDEEEEEDRKPDNLKLHEFQEQNTIEAAKKVAESILEQAMKAGGTKNPYSTNSVDEDRSLTKDFGLKLSNNMIAQAESVGKILKEVASSRFKDENNDLASVSRLVDNATNSMSFNSYFRSDVVNQMEQSDEEGLVASGSASESNNSGPEDMAGSQEPKKKSAYSSAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAVSLYVPIEDVNEPLPVPKSVEEIELQQQQQLLQQQQQLQQQKKLEEQKEFEKIQTPPQKPTAPTPENPEPAVSANSTPSANVVCKVEPIPQIVSSSELPFKCHLCDSSFAERLQCLDHIKIHHAQEFALLLSKGAIDNEADVNSQVQSTEDDEKRDESRGKYPDYTNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSNGGHSGNGATNANNSGSDDDDDEQPPTSMSLATTLRSHTIQEIFSKATSEWRNSRLSGEHKENIEEHNNQSDLIGNLLGISDQGILNKLLSSADEAAKFLGVDK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01223735;
90% Identity
iTF_00672401;
80% Identity
-