Basic Information

Insect: Ephialtes manifestator
Gene Symbol: MBD-R2
Assembly: GCA_963970395.1
Location: OZ019971.1:2906643-2932109[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.4e-17 2.8e-13 50.7 0.2 6 69 548 611 543 619 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.4e-17	2.8e-13	50.7	0.2	6	69	548	611	543	619	0.90

Sequence Information

Coding Sequence: ATGAAGCGACGGCGTATAACGCGGTCGCGTGCTAGCAAAGTACTGCCCCCGGGGCCGATGGGAATGGCGCGCAAATGCTGCGTAAAGAATTGCGATAGCGACGGTCAGGAAGTTCGTTTCAAGGGTTTGCCCTTGCACAAATTTCCAAAAGACGCTGCTCTCAGAAGTAAGTGGCTCGTTAACGGGGAATTTGAAACAAACTTCAAACCCACGCCCGGTCAATTCGTCTGCCATAGACACTTCAAAAGAGCCGACTACGAGATTATAAAGGGACAAAAATTTGTTCTACGTAAAGGCTCGGTGCCCACTGTTTTCGCTGATTATGACAATCATCCAGATCCCCTAACAATGCCAGTAAGAACAAACACTTCGTATCCTCAGGAGGATCTGGATTTGATTAATTCAGAAATATTGAACATGGATAGCGCAACAGCAGAGCCTCCGCTGTTTTCTGAGGATCGTACACCAAGATCCGATAGTCGCGGAGAGGCCTACAATTCCAGGCCAGGATCTTCGGCGGATTCCTTCAATCCATTCGAAAGCTCTGAGATAACAGATTCAGCATGCAGAGATAACGACGATATATCATTGGCCATAGAATCAGTTGCGGAAACACTGGAGCACCAAGCTGAATTATTACCTGATGCTGATTATTCAGTCCCGGAGGAAAGTGAGACAAAAATGGAAAATGCACCTGACGAATCGAATATCATCAAGGAAGATCTCAAAGGAATTAAGACGGAGGAGGATAAACCATTGGAAAAAGTAGCAGAACCTCTGCCAGCGAAGCCCGTAAGCCGCGGATCTTTGAAGTTTTTTGCCGGCGCCAAATTGGAAGCAAAAGATTTCAATGATAAATGGCAAGTGTATTCGGCACGAGTGGTCGAAACGGACTGGGTCGATAGAGAAGTGTTGATACATTTTGACAAGTGGAGCTCCAGATTCGATGAATGGATACCTATGGACAGTTCTAGACTGAGAGTACTCCAAATGCAGCCCAGTGAGCAAGTTTGGGTACTTCCGACTCCGGAAACGAAGATGAGGGATTTCTCCGTTGGGGAAAGAATTCTCGCTACGTGGGCAGATGGAAGAAAATATCCAGCCATAGTGAACGCCGTGTTAGGAAACGaCAGATACGACGTGCTATTCGACGATGGATATGCAAAGATCGTCAGGTCCTCGAAAATGACCAAAATCGCGTCTACCACGGAAAAGAAAGCCATGGAAGGTGATTCTTACATAGGAAGTAAGCAGGAAAGGAGGGACAAAAAGCGCAAACATACAGTAATGGAGCTCTTTCAAACTCACCCAAGAAAGCGTAACAAGAATGAAGCAGAAAAATCACTGAAAAAGGAAGAAATTAGCGTCGGCGATGATGCTAACAATTGTCACTTAGATAGCAGTATAGAACTGGACAGTTCTGGGCTTGGAACTTATTACGACTCAGGCGCAGAGGTGTTACGGGGTTTTGAGAATACTAAGCCAAAAATGAAGACATACTCAAAAAAGATGAAGAAAGATATGCACAGAAACGACACGGATCAGGAGGATGATGTTGGTCCTGAGTGGATCGATGGAGAGCCTCAGGGTATTGAGACCTTCATTGTCGATGGAAATGATGGATCACGACGTTCAATTATCGTGGCGGACCGGAGATTACCACCCATTTGGCAAAAACATTTTACCCAACGAAAGGCCGGAACATCTGCTGGAAAGTGGGACGTTCTTTTCGTTCAcaAGCCGAGTGGCAAAAAGTTCCGATCGAGAAACGATATTCGAGCGTTCATGGAGAGTCAGGGTCAATTTGACTTCGATCCCGAGATGTTTGACTTCTGTATTCATCGCCGAAAGAGCAAAAACTCGATCGCTCGACTCAAGTCTGAGACTTCAGGTGAACAGCCAAAGAAGATCAAAACGCTATTGCCAAAGACAAAAGCGATACCGTTGACGCCGGAAAATTCGCTGCTGGTGCCGCCAATTCCGTCGGAAATATCGATACCGATTACATCGACGACAACGACGCCTGTCGAGGATGGTGCCGTTTTCATCGGCGGTCTTCGTGTTGAGATGGAGGACAGCGCGTACAAGTGTCCAAAAGAGGGATGCTGCAAAAACTTTCGAAAGGAGAATCTTCTTCAGATGCACATCAAGCATTATCACCCAGAGTATTCTAAATTCTTGGGTTCGACACCTAATGTAGCGGATTTGGCTTACGCTCGTACAATCGGTGAGTCGATTGTAGATATAACGCCCAAAAAATCGAGCAGTCATTATCtggaaaaaataagcaaatttgAGAAGCGAAAAGCAGCGCACGAGAAGCCAATTGCTCCTGGAGCTGTGATTGGGTCCTCGAGGCAGACAATTCCATTGCTCGCGACTTCTCCGCAACCGACAATCAATTCTGGCACAGAAATCGTTGCTCACGATAAGCTTATGAATCTTCCACTTCGCGATGATTCGAAATTTGAGCTTATGTCGCCGATGTCGAACGCGAGTATTGATATGGACGAAGAATTGGCTAAAAAAGGTGATGCGAGTTGCGCAATGTCGCCCGGAGCACTTTTTGATCTCAAGATTCGCGAAGAGAAAACTCAGGTCGGAATCAAGACGCTTCTGCCGGTTAGGCCGGCAGCGCCGAACACTGATTCGTCGAGGCTCGATAGATCGAAGTCTCTCGACGAGGGTATTCATTCGGATAAAGGAAAGAATCATCGGAGGAGACAACTGTCCGAGTACGGCTCCGAATTTGCGAGATGTAAAGGAAGACAAGGCATGCAGGAGCTTACGGATGATTATGGGGATTTAGATGACAGTGCATTGGATGCGGAGGGTCCAGCTGGCCTCATGTATAGATTCAGTCGTAGGAAATCGGACGCAAAGAGTGACGAAAACAGCCAAAGCAGTCAGCTAAACGATTCTCGACTTGAAAAAGCCGATACCCCGAAAGGGGATGCTGCTAAAAGTGATATTAGTAACGAAgGTAACGGCGTTATGGTGATGATCAACGGCGAGATGATTAAACTCGAGCAACTTCGAAgggaagaaataataaattgtacCTGCGGATTCATGGAGGAGGATGGGCTTATGATTCAATGCGATCTCTGTCTCTGCTGGCAGCATGGACATTGCAATGCCATCGAGAGGGAAAAAGACGTaccggaaaaatatatttgctatATTTGTCAACATCCTTACCGTCAGCGTCCTTCAATGAAATATCTGCATGACCAGGAATGGATGAAAGATGGAAAGCTGCCGAGTTTGACGGAACGTACCAAAGATCAAACTGTAATCAACCAGAGGACCGCAATGCTAAAACGAACTTACGATTTGGTAGCGGCATTATTGCAAATCCAGCAGATTCTTCATAGCCTTCGTGTTAAAATCAGCGTAGCTCAGCAAAAAGATCATCCCAAGCTCTACTTGTGGGCGAAAAATTGGGAAAAGTCGGAGGTCCCCGAGCCTATCGTCGAACCAATACCGGTAATGCGTTTAGTTCAGCCAAAAGTTGAAGTACCCGAACTCGGAGTGAATGTAACCGTCGAACCGAAAACGGAAATCGCTGCTGTATCCAACGAAAATCTTGATGAAAAGTCAATTGCTTCCGACACGGAACTGATGAAAATTCTCGAAGAGGATAGCACACCCGCGGATGAATCTAAAGGAACGTGCAAGAAGGAAGATCCAATAAACTCGACGAGCGATCATATTCTCTTGGAAGCATTGACCAAGAATGAGCATACTGATCAGATGCAAAATCCTTCATCTACTCCGGAAATAAAGAACGAAGATGGCGAGTCGATGAACGACGCATCAACGATAAAAACAACGTCTACCGATGTCGAAACCCCTGAGGCAATGACCCCAGCTGAATCTATTCCCTCAGTTCCACCCCAGGAACCCGTTGCACCTTTGCAACCCTTTATACCGGAGCCTGAAGCACCAATCGATCCCGCAGAGTGTCGACAACGACTTTTGGAGCACATCGATCACTTTCAAAATCATATTGACTCCAGATTGACTACGATCGAGGCTCAAGTCGATGTGTTGGAGGCAATGGATCCCGACGAAGGAGTGTTACCATCTTCGGACATTGAACGTCGAACGAAGCAAACCGTGCAAATGCTTCTCCGAGATTTGAATACTATCCGAAAATTGGCTGCTCTCTGCTGA
Protein Sequence: MKRRRITRSRASKVLPPGPMGMARKCCVKNCDSDGQEVRFKGLPLHKFPKDAALRSKWLVNGEFETNFKPTPGQFVCHRHFKRADYEIIKGQKFVLRKGSVPTVFADYDNHPDPLTMPVRTNTSYPQEDLDLINSEILNMDSATAEPPLFSEDRTPRSDSRGEAYNSRPGSSADSFNPFESSEITDSACRDNDDISLAIESVAETLEHQAELLPDADYSVPEESETKMENAPDESNIIKEDLKGIKTEEDKPLEKVAEPLPAKPVSRGSLKFFAGAKLEAKDFNDKWQVYSARVVETDWVDREVLIHFDKWSSRFDEWIPMDSSRLRVLQMQPSEQVWVLPTPETKMRDFSVGERILATWADGRKYPAIVNAVLGNDRYDVLFDDGYAKIVRSSKMTKIASTTEKKAMEGDSYIGSKQERRDKKRKHTVMELFQTHPRKRNKNEAEKSLKKEEISVGDDANNCHLDSSIELDSSGLGTYYDSGAEVLRGFENTKPKMKTYSKKMKKDMHRNDTDQEDDVGPEWIDGEPQGIETFIVDGNDGSRRSIIVADRRLPPIWQKHFTQRKAGTSAGKWDVLFVHKPSGKKFRSRNDIRAFMESQGQFDFDPEMFDFCIHRRKSKNSIARLKSETSGEQPKKIKTLLPKTKAIPLTPENSLLVPPIPSEISIPITSTTTTPVEDGAVFIGGLRVEMEDSAYKCPKEGCCKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIVDITPKKSSSHYLEKISKFEKRKAAHEKPIAPGAVIGSSRQTIPLLATSPQPTINSGTEIVAHDKLMNLPLRDDSKFELMSPMSNASIDMDEELAKKGDASCAMSPGALFDLKIREEKTQVGIKTLLPVRPAAPNTDSSRLDRSKSLDEGIHSDKGKNHRRRQLSEYGSEFARCKGRQGMQELTDDYGDLDDSALDAEGPAGLMYRFSRRKSDAKSDENSQSSQLNDSRLEKADTPKGDAAKSDISNEGNGVMVMINGEMIKLEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYICYICQHPYRQRPSMKYLHDQEWMKDGKLPSLTERTKDQTVINQRTAMLKRTYDLVAALLQIQQILHSLRVKISVAQQKDHPKLYLWAKNWEKSEVPEPIVEPIPVMRLVQPKVEVPELGVNVTVEPKTEIAAVSNENLDEKSIASDTELMKILEEDSTPADESKGTCKKEDPINSTSDHILLEALTKNEHTDQMQNPSSTPEIKNEDGESMNDASTIKTTSTDVETPEAMTPAESIPSVPPQEPVAPLQPFIPEPEAPIDPAECRQRLLEHIDHFQNHIDSRLTTIEAQVDVLEAMDPDEGVLPSSDIERRTKQTVQMLLRDLNTIRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00652774; iTF_01497418; iTF_01497476; iTF_01207413; iTF_01207359; iTF_00414304; iTF_00414374;
90% Identity: iTF_00652774;
80% Identity: iTF_00652774;