Basic Information

Gene Symbol
-
Assembly
GCA_905220475.1
Location
HG992026.1:8403589-8404424[+]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3 5.7e+03 -1.8 0.0 15 25 19 29 7 37 0.60
2 2 1.8e-26 4.4e-23 81.9 5.7 2 69 47 115 46 116 0.91

Sequence Information

Coding Sequence
ATGGATAAAAATAAAAAAATGTTCATTCCTTTACTTTTCTTTATTTTTATTTCAGTGGAGACGAATGTGTACCAGCAAATTGGTCAGAGCACCGAAAACACAGTATGTATCGAGATGGACTTGCTGAAAGTTGGCTCGGAGCCGGTCGGCATGCGCTGTCCGTACTGCCAAGAGGACATGATGACCAGGGCCACCTATAGAAATACAGCCCTCACGCACATCATTGCTATCGTCTTTGGGATCCTGTTCTGGTGGTTATGCTGCTGTCTAATTCCATACATGACTAAAAGGTGGAAAAACGTTGAACATTATTGTCCCAACTGTAGTAGATTTCTGGGCGTTTATTCAAGAAAATCTATTATTTAG
Protein Sequence
MDKNKKMFIPLLFFIFISVETNVYQQIGQSTENTVCIEMDLLKVGSEPVGMRCPYCQEDMMTRATYRNTALTHIIAIVFGILFWWLCCCLIPYMTKRWKNVEHYCPNCSRFLGVYSRKSII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00390969;
90% Identity
-
80% Identity
-