Ecav006796.1
Basic Information
- Insect
- Ectemnius cavifrons
- Gene Symbol
- slp2
- Assembly
- GCA_964023945.1
- Location
- OZ030378.1:15795394-15796641[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 6.2e-43 5.4e-40 135.5 0.2 1 87 106 191 106 192 0.97
Sequence Information
- Coding Sequence
- ATGGTGAACATGGAGGGTTCCAGCGAGCAGCATACGGTGACGGCTTCGCCACCACCGCGAGCTGCGCTCAAGAGCAACTTCAGCATCCGCAGCATCCTTCCGGAAGCTTGCGCCGGCACCCCGGCACCTTCCGTTAGTCAATCACTGTCGCCAGACGTAAGTCACGTCGACGACAGCGATGAATCAAGCGACCTCGACGTTACCGGCGACGGTGCTGAAACTCCCCCGTTGGATTGCTCCACCAATGCAACATCCACCAGTCCGAACAGTCAAAAAGACAACAAGGATCAACAAAACGAGGATAAGAAAAAATCGGAGAAACCACCATACAGTTACAACGCCTTAATCATGATGGCAATTCGTCAGAGTCCTGAGAAACGTCTCACTTTGAACGGCATCTACGAGTACATCATGCGCCACTTTCCTTATtacgagaataataaacaAGGATGGCAAAATTCCATCAGACATAACCTGTCTTTGAACAAGTGCTTCGTCAAAGTACCACGGCACTACGACGATCCCGGCAAGGGTAACTACTGGATGTTGGACCCGAGTTCGGAGGATGTCTTTATTGGAGGAACCACTGGAAAGTTGAGGCGAAGGACTACAGCGGCTTCGAGATCTCGTCTAGCAGCTTTCAAACGTAGCGTCGTCCTCGGTGGACTTTATCCCACACCATATCCTCCACCAGGATGGCCAGCATCCCTTTATACTTTGCCATATCTGCATCGAGCTGCTGCATATCCACCAGCAACTGGAGCATACACAACTCCAGCTGGTTATCCAGCTAGTCTTCTACCGGGTGCGGCTACCACTTCCGCCACCAGTTTACCTTGCAAGCCTCAACCCTTGCCTGCCACCGCTGCTCCACCAGCTCACGGTGCTTTCTCCATGGAAAGGCTTCTTCAAGCACCAACCGGCTATCCAAGCGGAATCGGTGCACCAGGAATTCCAACGCCAGGCAATCCTTATGATTTCTATAGTACTCTAAGATCGCTTGCCGCGCATCAACAACACCAAGCAGCAGTATTCAGTCAGCAGCCAAGGTATCATATGAGTCAAGCACCAATCTTAAGTCAGCCAACCTCGACAACAGCATCACCAGGAAGCAGTCCTGAACCGATGTCACCGCATTCTCCACCAGTAACGATTTGCAGTTCGGTACAACAACCAAGACCTATGCCACATAGTCCACCGCAACTTCTTCTTAAACCGATCACTGTTCTTACTGGAAGACAGAGTTGA
- Protein Sequence
- MVNMEGSSEQHTVTASPPPRAALKSNFSIRSILPEACAGTPAPSVSQSLSPDVSHVDDSDESSDLDVTGDGAETPPLDCSTNATSTSPNSQKDNKDQQNEDKKKSEKPPYSYNALIMMAIRQSPEKRLTLNGIYEYIMRHFPYYENNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSEDVFIGGTTGKLRRRTTAASRSRLAAFKRSVVLGGLYPTPYPPPGWPASLYTLPYLHRAAAYPPATGAYTTPAGYPASLLPGAATTSATSLPCKPQPLPATAAPPAHGAFSMERLLQAPTGYPSGIGAPGIPTPGNPYDFYSTLRSLAAHQQHQAAVFSQQPRYHMSQAPILSQPTSTTASPGSSPEPMSPHSPPVTICSSVQQPRPMPHSPPQLLLKPITVLTGRQS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00867201; iTF_01254604; iTF_00868575; iTF_00867946; iTF_00765346; iTF_00254883; iTF_00297347; iTF_00292741; iTF_00254119; iTF_00252617; iTF_01475250; iTF_01472979; iTF_01130613; iTF_01474485; iTF_01473719; iTF_00292091; iTF_00251868; iTF_00294270; iTF_00295808; iTF_00295042; iTF_01198469; iTF_01199207; iTF_00770175; iTF_00293518; iTF_00291336; iTF_01394929; iTF_00253366; iTF_00298108; iTF_00296573; iTF_01453891; iTF_00264081; iTF_00264815; iTF_01520035; iTF_01407971; iTF_01405494; iTF_01407033; iTF_01406302; iTF_01408863; iTF_00460294; iTF_00898567; iTF_00126505; iTF_00125713; iTF_00127250; iTF_00127989; iTF_00129531; iTF_00128768; iTF_01089801; iTF_00306060; iTF_01355116; iTF_01476738; iTF_00109636; iTF_00014533; iTF_00181125; iTF_00015857; iTF_00016501; iTF_00181782; iTF_00015196; iTF_01245029; iTF_01477381; iTF_01261673; iTF_00729100; iTF_00280460; iTF_00730541; iTF_00279776; iTF_00182449; iTF_01475993; iTF_00142289; iTF_01498001; iTF_00729874; iTF_01077280; iTF_01421364; iTF_01422728; iTF_01423448; iTF_00676501; iTF_00045942; iTF_00046763; iTF_00047774; iTF_00417366; iTF_01523173; iTF_01015613; iTF_00317274; iTF_00316578; iTF_01354426; iTF_01120027; iTF_01228828; iTF_01228197; iTF_00385083; iTF_00884861; iTF_00393406; iTF_01255343;
- 90% Identity
- iTF_01453891;
- 80% Identity
- -