Basic Information

Insect: Dynastes tityus
Gene Symbol: topi
Assembly: GCA_029618875.2
Location: JAROYD020000003.1:53615507-53631385[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0014 0.16 14.1 1.3 3 21 128 146 126 147 0.93

2 13 9e-07 0.0001 24.1 0.9 1 23 172 194 172 194 0.97

3 13 0.014 1.6 11.0 2.0 2 23 201 222 201 222 0.95

4 13 2 2.3e+02 4.1 0.0 2 19 241 258 240 261 0.91

5 13 0.0032 0.38 12.9 1.1 2 23 324 345 323 345 0.96

6 13 0.31 36 6.7 3.3 2 20 388 406 387 411 0.82

7 13 0.063 7.4 8.9 0.1 1 23 539 562 539 562 0.97

8 13 0.0046 0.54 12.4 0.2 1 23 566 588 566 588 0.97

9 13 2e-05 0.0023 19.9 5.4 1 23 594 616 594 616 0.98

10 13 0.04 4.7 9.5 0.2 1 23 622 647 622 647 0.96

11 13 0.2 23 7.3 2.9 1 23 653 675 653 675 0.86

12 13 2.6e-05 0.0031 19.5 0.5 3 23 683 703 681 703 0.98

13 13 6.6e-06 0.00077 21.4 0.7 1 23 709 732 709 732 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0014	0.16	14.1	1.3	3	21	128	146	126	147	0.93
2	13	9e-07	0.0001	24.1	0.9	1	23	172	194	172	194	0.97
3	13	0.014	1.6	11.0	2.0	2	23	201	222	201	222	0.95
4	13	2	2.3e+02	4.1	0.0	2	19	241	258	240	261	0.91
5	13	0.0032	0.38	12.9	1.1	2	23	324	345	323	345	0.96
6	13	0.31	36	6.7	3.3	2	20	388	406	387	411	0.82
7	13	0.063	7.4	8.9	0.1	1	23	539	562	539	562	0.97
8	13	0.0046	0.54	12.4	0.2	1	23	566	588	566	588	0.97
9	13	2e-05	0.0023	19.9	5.4	1	23	594	616	594	616	0.98
10	13	0.04	4.7	9.5	0.2	1	23	622	647	622	647	0.96
11	13	0.2	23	7.3	2.9	1	23	653	675	653	675	0.86
12	13	2.6e-05	0.0031	19.5	0.5	3	23	683	703	681	703	0.98
13	13	6.6e-06	0.00077	21.4	0.7	1	23	709	732	709	732	0.98

Sequence Information

Coding Sequence: ATGAACAATTCAGATATAAGTTTCAtaaaagttcatcaaatggACCCTGATGGTACTGTGAGCTCTTATCAATACGAAGTGGACAATATATCACAGGAATTTGTAATGAAGACAAATATTGCCCCtacttttaatacaaattttgatATTCCATATAACTCCAGTGAAAAATTTAACTTTAAGTATCGTTTCTTGGATTTGGATAATTCATCAATAAGAGTTATAAAGATTGGAGGAGTTGAAGATCTCAATCCAATGAATTATGCTACTGAAATTTCAACTGTGTTACACGATCCTTATGAATGTAAATCAATTGTTTGTAATAATATTGTTCAACCAAAAAGGGAATCCAAAATACCAAATATTCCAACTATGATTATTTGCCAAAATTGTGATACAAATTTTCCTACAAAATATCAATATCAACGGCACCAATGTGAATTTAATGCAGATAAAGTTGTTCTTAAACCAAATGTCGATATAAAAGACATCGATAAGGGTATGCGAATGAAATTTGACTGCCCAACATGTGGAAAACAGTTTGTTAGTAAGAATAATTTGGAGAGACATCAGACAAGTCATGACGAGACAAACATTAATGTCTGCGAACATTGTAATAAGCAGTTTGTTAGTGAGAATCGCTTACGAATTCACAAAGAAAATCATTGTAAGAAAGCGGGTGACATATCTAAATTCTACAGAAGTGATGTTACTGTTTGGAAATGTCTCAGTTGCTATCAAGTATTTGCAACACCTGCGTCAGCAATGAAGCATGCAGAAAATTGCATCGAAAGTTTGAGTTTAAATGTGTCAAAGAGTGTTGAAGGAGATGATTCTAAGATAATATCTGAAGAAGGGAAATCACCGGAAACTTCTGAATTTATAGACAATGGAGTTATGTTTAATGGTAAATTTAACGacaatgttataaataaaaatgtccaAAAGTTTTTAACTGAACTGCTTTTGCAATGTGAGTATTGCAATCGTACTTATGCGGATAAAAAGTGGTTACTATTTCATCAAAAATCACATACAACATGTACAAACTATGAATGCATAACTTGTAATTTAACGTTTGATTCGTATGTCTTAGCTTCCAAACACTGGCTTACAAAGTGTTCAGATGAAGCTAATCTTTTCTATTTACCAAAGCTGACGTATTGTGAATATTGTGATAGAACTTTCAAATCACATGAGATTCTATATAcgcataaattcaaaaaaaaacattatacacCCAAAATATTTACTCCCGTTGAATCTAATGCTGCAGATGTTAAGCAGGAAACTCTAAAAGATAATTCTatgaaaattattgaaaacaaagaagcaattgtaaaattaatagaAGATGTGCTTTTTGCTATGAATGTTCCAACAGAAAGTAAGCAACGTGATAGCAATAATAGCAAGGAGTCTGCTGAGGCAACGGAGAATTCTCAATCAGAAGAAATTGTTGTCAAATCTGAAGCATACAGTGAATCTAGTAGTGTCTCCAAATCAGACACATCACAAGACTCGGAAAAGAAAAAGCGTGGCAGAAAGAGAAAATATCCAAGACAAACAACGAAAACTAAGCGTTTAACTGTTGTTGTTGAAAATGGGTACAAATATCAATGTGAAaagtgtataaaattatttgatagtGTGGCAGATTTAGAAAATCATAGGGAAATGGACCATCCAGCAAAGTTTAAATGTGAAGAATGTGGACAGgtcGTTCACAGCGCTAAAGCTTTACTAATACATAGTAGGGCACACCAAAGTTTAAAGCCATATGTCTGTGAGATTTGTAAGAGGTGCTATTCTCAGACTTCCCATCTGTGGCAACACATGAGGTTTCATCAAGgtATTAAACCATTTGCTTGTCCTCATGAAGGTTGTGAAGCCAGGTATACAATTCGTCCAGATTTGAAAGATCACATAAGAAAAGTGCATACTAGAGAAAGACCATTTAAATGTTCAGTGTGTGATAAATGCTTCTTAACTGGATCTGTCTACTATCAGCATCGTTTGATACATACTAACGACCGCAGATATGGCTGTGATATTTGCCAAAAGAGATTTTTCCGTGCTGATGCCCTAAATAACCACAGAAGGATCCATACCGATGAACGTCCCTATCCTTGTGATATATGCGGGAGGCAATTTAGACAGAAAGGTGACCGCAATAAGCATGTACGAACACAGCATCCGTCCTAA
Protein Sequence: MNNSDISFIKVHQMDPDGTVSSYQYEVDNISQEFVMKTNIAPTFNTNFDIPYNSSEKFNFKYRFLDLDNSSIRVIKIGGVEDLNPMNYATEISTVLHDPYECKSIVCNNIVQPKRESKIPNIPTMIICQNCDTNFPTKYQYQRHQCEFNADKVVLKPNVDIKDIDKGMRMKFDCPTCGKQFVSKNNLERHQTSHDETNINVCEHCNKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCLSCYQVFATPASAMKHAENCIESLSLNVSKSVEGDDSKIISEEGKSPETSEFIDNGVMFNGKFNDNVINKNVQKFLTELLLQCEYCNRTYADKKWLLFHQKSHTTCTNYECITCNLTFDSYVLASKHWLTKCSDEANLFYLPKLTYCEYCDRTFKSHEILYTHKFKKKHYTPKIFTPVESNAADVKQETLKDNSMKIIENKEAIVKLIEDVLFAMNVPTESKQRDSNNSKESAEATENSQSEEIVVKSEAYSESSSVSKSDTSQDSEKKKRGRKRKYPRQTTKTKRLTVVVENGYKYQCEKCIKLFDSVADLENHREMDHPAKFKCEECGQVVHSAKALLIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCDKCFLTGSVYYQHRLIHTNDRRYGCDICQKRFFRADALNNHRRIHTDERPYPCDICGRQFRQKGDRNKHVRTQHPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00956516; iTF_00626501; iTF_01253009; iTF_01121116; iTF_00990900; iTF_00434342; iTF_00070647; iTF_01124084; iTF_00308275; iTF_00741216;
90% Identity: iTF_01121116;
80% Identity: -