Dpha012865.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Dryadula phaetusa
Gene Symbol
Foxd3
Assembly
GCA_032432895.1
Location
JAOYRS010000051.1:1583588-1584472[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.4e-41 6.4e-38 129.2 0.0 2 87 91 175 90 176 0.97

Sequence Information

Coding Sequence
ATGGAAGACGACTTGACCATGTACCGCGATATGATCATCGAGGGAGATCTACCGCTCGACCTGAGGCCGCCGCCTAGGCTCTACCTGCCGCACTACCTGCGGGACGATAGAGAAGAATACCCACAAGATGACACCTACGTATCTGTTGACGAGGACACGCCGGATTTGCCGCCGCCATCAAGTGACTCGGAGAGATACGACGCGTCCAGCCCTAGTGACAAACCGAATTCACCAAAGAAACCAAAACAGAAGTCCTCATCGCAACTCATCAAGCCGCCCTACTCGTACATAGCGCTTATAACGATGGCAATTCTACAATCTCCACACAAAAAGTTGACGCTGAGCGGGATCTGTGAGTTTATTATGACTAGATTTCCATATTACCGCGAAAAGTTCCCAGCGTGGCAAAACTCTATCCGTCACAATTTGAGCCttaatgattgttttattaaaattccgcGGGAGCCCGGAAACCCTGGCAAGGGTAATTACTGGACGTTGGATCCTCTAGCCGAGGATATGTTTGATAACGGTAGCTTCTTGCGCCGTCGGAAGAGATACAAGCGTCCTGCCCCATCTCTGCAACACGCTCATGCAGTTGTGGCGATGCTTGCGAGAGAGGCGTATGCCCCGCTTTTGCCTTTGCCGTGCTACTTGCCGCCGTCGCCTCTGCTATCGCTACCTCGACCGCCGCCGGCAGCGTTACGGCCCGTCCCACTGCCACCACGAGTCCCAGAGACGACAGACACTCGCGGGAAAAGGTCTAGGAACGGTTTTTCAATTGAATCTATCATCGGATCGCAAGAGAATCAAGCTGAGCCCCGACGGAGCGCGTTTTCACCGCTACACCAAGGCGCGGGGCCGCCGGACGACTGGGCGAGATGA
Protein Sequence
MEDDLTMYRDMIIEGDLPLDLRPPPRLYLPHYLRDDREEYPQDDTYVSVDEDTPDLPPPSSDSERYDASSPSDKPNSPKKPKQKSSSQLIKPPYSYIALITMAILQSPHKKLTLSGICEFIMTRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPLAEDMFDNGSFLRRRKRYKRPAPSLQHAHAVVAMLAREAYAPLLPLPCYLPPSPLLSLPRPPPAALRPVPLPPRVPETTDTRGKRSRNGFSIESIIGSQENQAEPRRSAFSPLHQGAGPPDDWAR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00695284;
90% Identity
iTF_00778600; iTF_00776586; iTF_00774320; iTF_00780848; iTF_01181712; iTF_00782450; iTF_00775861; iTF_00777814; iTF_00457822; iTF_00779327; iTF_00775072; iTF_00781632; iTF_00420354; iTF_01034340; iTF_00421157; iTF_00419591; iTF_00959976; iTF_01205512; iTF_01202281; iTF_01204681; iTF_01204682; iTF_01203852; iTF_01203054; iTF_00958513; iTF_00959220; iTF_00461365; iTF_01033528; iTF_00842457; iTF_00418778; iTF_01206363; iTF_00642151; iTF_00984837; iTF_00985803; iTF_00687719; iTF_00780073; iTF_00114747; iTF_00770914; iTF_00827787; iTF_01207918; iTF_00352847; iTF_01062561; iTF_01532835; iTF_01063556; iTF_00711621; iTF_00446923; iTF_00036429; iTF_01533741; iTF_01084943; iTF_00039600; iTF_00041585; iTF_00928466; iTF_00685236; iTF_01061687; iTF_01084055; iTF_00040600; iTF_01064441; iTF_00043290; iTF_01531770; iTF_00445916; iTF_01020996; iTF_00801608; iTF_00954218; iTF_01091502; iTF_00353886; iTF_00276080; iTF_00695284; iTF_01077998; iTF_00824514; iTF_01507874; iTF_01078883; iTF_01506148; iTF_00843308; iTF_01079702; iTF_01080539; iTF_01506975; iTF_01018388; iTF_00288666; iTF_00722849; iTF_00896580; iTF_00212233; iTF_00247850; iTF_00213227; iTF_00246992; iTF_00159637; iTF_00777245; iTF_00457054; iTF_01178213; iTF_00744414; iTF_00786575; iTF_00925540; iTF_01151034; iTF_00166754; iTF_01082244; iTF_01437774; iTF_01438705; iTF_00795510; iTF_00635203; iTF_00634124; iTF_01561827; iTF_00357229; iTF_01193421; iTF_00358328; iTF_00148292; iTF_00149183; iTF_01073412; iTF_01090496; iTF_01331236; iTF_01333537; iTF_00659270; iTF_00658165; iTF_00655900; iTF_00674118; iTF_00255624; iTF_00256659; iTF_00144375; iTF_00680329; iTF_00913419; iTF_01017547; iTF_00736429; iTF_00007816; iTF_00953327; iTF_00150292; iTF_01152852; iTF_00673300; iTF_00025084; iTF_00287868; iTF_00878677; iTF_00761432; iTF_01083105; iTF_01416579; iTF_01251556; iTF_00006891; iTF_01415628; iTF_01436824; iTF_00430426; iTF_00282075; iTF_00889000; iTF_00280939; iTF_00821584; iTF_00791007; iTF_00277180; iTF_01072255; iTF_00409094; iTF_00410087; iTF_00412328; iTF_00660116; iTF_00656950; iTF_00289432; iTF_00654042; iTF_01133530; iTF_00411227; iTF_00871104; iTF_00926400; iTF_00971040; iTF_00970214; iTF_01401088; iTF_00177886; iTF_00275056; iTF_01403251; iTF_01336633; iTF_01153662; iTF_01154824; iTF_01158522; iTF_00844126;
80% Identity
iTF_00775072;