Basic Information

Insect: Drosophila ustulata
Gene Symbol: MBD-R2
Assembly: GCA_035047365.1
Location: JAWNPT010000094.1:9899391-9903246[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.5e-23 1.9e-19 69.0 0.1 4 76 443 513 440 514 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.5e-23	1.9e-19	69.0	0.1	4	76	443	513	440	514	0.93

Sequence Information

Coding Sequence: ATGGGACGACGGTGCTGCGTAGCAGACTGTCCGTCGACGTCACGGCTTTTGGAGCACCACGGCGTCACCTACCACTCGTTTCCCATGGACGCCGTCATTCGCGCCATTTGGATAAAGAATTCGCGCATCAGCCTCGATCGGCAGATAACAAAGAGCGTGCTGGTTTGTTCGCGGCACTTCCGTCGTCTGGACTTTAATACCATACGCAATGGCAAGTATTTGCTGAAGCCTCGGGTATTTCCTACTGTCTTTCCGTGGGGCAAAATGGATCCTGCCGAGATTGAGGCCGATCATCGGGCGCTGCAACAGGCGTCGGTTGAGGGCTCTGGTGCTAACGGCTCGGCCAACAATTCCACCAGCGAGGAGGTGATCAAGGCCACGGTTGATCAGATTGTGTCGCAAATCTTGGAGGAGACGGCAGAACGCAAAGCAGCAGAAACTACCAAAACGGATGTGGCTAAGTCAGAGGACACAGAGTCGGTTAAGGAAGCAGCTGGAGATGATGCCGCAAAAACGACGCCAGCGAAAGATGCTGTTGATGATACCTTGGCTGAGGCTTCCCAGGCTCCAGCGGATGCCGCTGATGAACTGCGCGCCACAGCCAACAGCTCAGTGTCGCCAGTGTCGAACTCTCCGCCCAAATATAGATCGCCCACAAATCTGACCATTGGCGCACGCCTCGAGGCATTGAGCGTAGACAGCGCCTGGCTGCCAGCGCGTATCGTTGAGATCAATCAGGCAGAGCAGACTCTGCTCATACGCTTCGAGCGCAACAGCAAGCTGAAGACAACGCCATCGACGACGGGCGGCTACCAAGAGTGGATCGCCTTCAAGTCGGAGCGTTTGCGGCAGCGGATCAGCTCGCGAGTTCTGCCCGTGTTCGATCTGGAGGAGAAATGCATGGCGCGCTGGTCGGGACCACGCAAGTTTCCGGGCACCATCAAGAAACTGCTGGGCAACGACACCTACGAGGTGCTCTTCGATGATGGCTACACCAAGAATGTGCGAGCCTTGCACATGGTCAAGCTGCCGCGCCAACTGTCGGCCGCAAGCGACGCTGCTCCCGCTGAAGTAGAAAGCCCAAGTTCACAAGCAGCTTCTGCTGCACTTAAGCGGCCAAGCTCTGGAGCAACAAGCATCAACAAGAAGAGCAAAACGGCACCCCAACGCAAAGATTGGCCACTTCTGGATATGTCAAATTTGGACTTGGTTGGTTTGGGTCTTCCGGACATTCCACACGATGGCGAGTGGACTTGCCACTGGGTGAATGATCAACCCATTGGCACCGAAGGCTTTCTGATTGTGGGCGAGCATCAGAAGCCCACGGTGATTGTGCACGACTGGCGTCTACCACCGGGCTGGATCAAGCACATGTATCAACGCTCCAATGTACTCGGCAAATGGGATGTTATCTTAGTGTCGCCCAGCGGTAAACGCTTTCGCTCCAAGTCGGATCTGAAGACGTTTCTGGAGTCACAAGGTCTGGTCTACAACCCAGACATCTATGACTTTAGCATTCATCGGCGACGTGCTAAGGATATCAATGCTTATGTGTACACACATGACTATAGTCCACAGCAGCCGGCTAAGGCGAAGCTGCAGGATGTGTCGCTCGACAGCACAACCACATCACAGGATCTGAACAGTAGCAAGCTGTCGACTGCCACGCCCGCAACCACACCGATATCTGCGGTCGCTACGCGTcgcacagcagcagaagaCAGCCAATACATGGAGACCCCAGTGGCGTCTTTGGTGCCGCCCGCTGAGTTAATGTCGCCTTCGCTGCAGTCTAAGAGCACTGATGTGGTTGGCTCGCCTACTGATACGGCTGCATCTAGCCCAGGGTTGGGCTTGGATGCGCAGAGCGCTGTGCTGGTCGAAGATGGTTATGCTTTCATTGGCGGTCTCAAGGTCCAGATAACGGACAACTTGTTCGTGTGCCCGCGTGAGGGATGCGGTAAAACCTATCGCAAGGAAGACTTTCTGCAAATCCACATTCGATATTATCACAAGGAGTTTGCTGAacATGTTAGTCATTGCCCCAAAATGCAGGAGCTGGCTGTCAAGCGTACGCATCCCTCTTCGATAGAGCAAGGCGATCAGACCCCTAAGAACCAAATACCAAATCAACAGTTCTTTGCCAAGCTGCACCAGCAGGATTTGCAGCACACTCGTGGCGCCAAACGACAACCGGCGGGAACAGATTCATTGCCCACGGCTCTAGAAGCATCACCAATTGTATCGCCCACCAAACCGGTGTCCTCCCCTAAAGCAGAAACGCCAATCGCCTTAAAAGCAAGTCCCCAGACTGCTGCTGGCGTTCCAGAACCTACGCCAACTGCTTTGCCAACCACCAGCGAGTCTGCGGCACCCATTCCGATCGAACCCACTAAAATGAGCCCAGCTGATGTCAAGCCGTTGGCGTCGAATCGATCCTCAAAACGTACTCGACCTTCATCTAGCAGACGTCAGTCTGGCTCGCGTAAAAGCAGTCGTCAACGAACTCAGCGTCGTCCGGTCAATGTGCCGGCCAACAAGAGTCCTGTAGCAAGTAAACTGCCCATGTCTGGCCTCGATAGCGAGGAGTCACGCCCATTGATCCATACGCTAGTGCCAGAGGTTCGCAATGAAGCCAAGAAGCGTCGTATTGGTGCCACGCCGGTTGGCTCACCGGCCATTCTTGATGCTGTATCGACGCCATCGCCCCATGATCAGATTGATATAAATGCGGCACTAGCTCCACCACCACCGCAACCCAATCAGACGCCACAGTACATCAAGGAAAACGGCGAATTGATTCGCATTGTGCGCATGCGGCAGGAAGAAATCATCAACTGCATTTGCGAATATGGCGAAGAAGATGGCCTGATGATACAGTGCGAGCTCTGTTTGTGCTGGCAACACGGCGCCTGTAATGGCATCGTCAAGGAGTCGGATGTGCCGGAGAAGTACGTGTGCTATATTTGCCGCAATCCACAGCGTGTGCGAGAGTCGATGCGCTTTAAGCACGATCAGGATTGGCTTTTCGAAGGCAAGCTGCCTGTGGctggatatcacacccccaaTCCACAGGCCACCAAAAAATGCGAGCTGTTGAAGCGCTCTCACACACTGACCGGAAATCTGTTGGACGCTAAGCGTTCCATGCACTCGTTGCAGGTGAAGATTAATATTGCTCGAAATCGCTGTCACCCCAAACTATACCTGTGGGCCAAGAAGTGGGATGAGGATCAGACGGACAACTCGGCCACGCCAGTCAAGCGTCCAAAGACGGAACCATCCGACTGGCCGCCAGCGCCGCAACCGGAGGCAGCCATCGATCCTGAAGAATGTCAATACCGCTTAATTGAGCATGTCAAAGTGCAACAATCGCTTTTGTTGAATCGCTTGAATGACATCGAAGGGGAAATGGATGAACTGGAAAAGGAAGATAATCTGAGCGATTATAAGGATGCAAGTATGTCCGCAACCAAAGATGCTCTCGCCACGTTCATCAAGGAATTGGAGACCTTAAAACGGCTGGCTAAACTGAACAAGGTTGTAAACATGAAAAACGCACAGAAGGAACAAGAAACAACTACCGAAAATCCCCAGCTGTGA
Protein Sequence: MGRRCCVADCPSTSRLLEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDPAEIEADHRALQQASVEGSGANGSANNSTSEEVIKATVDQIVSQILEETAERKAAETTKTDVAKSEDTESVKEAAGDDAAKTTPAKDAVDDTLAEASQAPADAADELRATANSSVSPVSNSPPKYRSPTNLTIGARLEALSVDSAWLPARIVEINQAEQTLLIRFERNSKLKTTPSTTGGYQEWIAFKSERLRQRISSRVLPVFDLEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRALHMVKLPRQLSAASDAAPAEVESPSSQAASAALKRPSSGATSINKKSKTAPQRKDWPLLDMSNLDLVGLGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVHDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKTFLESQGLVYNPDIYDFSIHRRRAKDINAYVYTHDYSPQQPAKAKLQDVSLDSTTTSQDLNSSKLSTATPATTPISAVATRRTAAEDSQYMETPVASLVPPAELMSPSLQSKSTDVVGSPTDTAASSPGLGLDAQSAVLVEDGYAFIGGLKVQITDNLFVCPREGCGKTYRKEDFLQIHIRYYHKEFAEHVSHCPKMQELAVKRTHPSSIEQGDQTPKNQIPNQQFFAKLHQQDLQHTRGAKRQPAGTDSLPTALEASPIVSPTKPVSSPKAETPIALKASPQTAAGVPEPTPTALPTTSESAAPIPIEPTKMSPADVKPLASNRSSKRTRPSSSRRQSGSRKSSRQRTQRRPVNVPANKSPVASKLPMSGLDSEESRPLIHTLVPEVRNEAKKRRIGATPVGSPAILDAVSTPSPHDQIDINAALAPPPPQPNQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPEKYVCYICRNPQRVRESMRFKHDQDWLFEGKLPVAGYHTPNPQATKKCELLKRSHTLTGNLLDAKRSMHSLQVKINIARNRCHPKLYLWAKKWDEDQTDNSATPVKRPKTEPSDWPPAPQPEAAIDPEECQYRLIEHVKVQQSLLLNRLNDIEGEMDELEKEDNLSDYKDASMSATKDALATFIKELETLKRLAKLNKVVNMKNAQKEQETTTENPQL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00553762;
90% Identity: iTF_00509093;
80% Identity: iTF_00614223;