Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.1e-23 9.6e-20 70.0 0.0 1 76 9 86 9 87 0.91

2 2 5.2e-06 0.016 14.8 0.0 27 76 175 235 156 236 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.1e-23	9.6e-20	70.0	0.0	1	76	9	86	9	87	0.91
2	2	5.2e-06	0.016	14.8	0.0	27	76	175	235	156	236	0.91

Coding Sequence: ATGCAATTAAATCCGAGCGTAACGATTGAACGCAAACGCGTGGACTGCACTGCTTTGCCAAAGGGTTGGCAACGTGAGGAAGTTCGCAAATCGGCGAACAGCAACAGCGCACCCAATAATAATAACAACAAAGTCGATGTCTTTTACTACAGTCCCACAGGCAAGCGAATTGAAAGCAAACCGCAATTAGCTCGTCAGTTGGGCAGCGAAATGTTTGATATTGGAAATTTTGATTTCCAATCGGGCAAAATGGTGCAGCAGCAGCAACGTTATTTGCCGTCGCCATCTATATCGCTGTACCGCTGTAGTGCCATACCTCCACTACCCAGTGGAAGAGGATCTGCCAATGCACTGAAACGAAAATATTCTAGAGGCCAGCCACAGATCTTACAAGGAGTGGATAAGGATGTGGTCTTCGAAAAGGACTTAATTGGCCAAGCCCAAGGCTGTACTGTCATCACTGCATCTAACTCTTCTTCAAATCTGCGCCATCAACAACAGCAACAGCATTTGGAACTCAGTCGTGCCCTACGCACAGATGTCTCTTTGGTGCCACCCATACGGCAGACTGCCTCTATTTTCAAGCAACCCGTGACAGCAATTAGGAATCATAACCAGGAATCCAACAAAGTGAAACATGATGCCAAACACGGCGCACAGGAGAAACCCAAGCAATTATTTTGGGAGAAACGTTTAGAACGGTTGCGTGCTTGTCATGACAATGGCGAGGAGCTGGATGATATTACATTGCCCAAAACCATACGCACTGTGGGCCCCAACGTTAATGAACAGACAGTTCTACAATCAGTGGCCACTGCCCTGCATATGCTCAACGCCGGCGTTCATGGTCAGAGCTCAACCAAGGCTGAGTTGACCAAAAACGCAATGGCCTTTATGAATCCCGAACAACCCCTGATGCATGCGGTAATCATCTCCGAGGATGATATACGAAAGCAGGAGGATCGGGTTAGTGTGGCAAGACGAAAACTGCAAGATGCTCTAAAAACATGA
Protein Sequence: MQLNPSVTIERKRVDCTALPKGWQREEVRKSANSNSAPNNNNNKVDVFYYSPTGKRIESKPQLARQLGSEMFDIGNFDFQSGKMVQQQQRYLPSPSISLYRCSAIPPLPSGRGSANALKRKYSRGQPQILQGVDKDVVFEKDLIGQAQGCTVITASNSSSNLRHQQQQQHLELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHNQESNKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2