Dtrs002082.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila tristis
Gene Symbol
fkh
Assembly
GCA_018150885.1
Location
JAECWT010000002.1:7995826-7998496[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.5e-40 5.9e-37 125.4 0.1 2 88 182 267 181 267 0.98

Sequence Information

Coding Sequence
ATGCAGAAGCTCTACGCGGAGCCGCCGCCCAGCAGCGGCGCTCCGGTGAGCATGTCCTCTGGGGGCGGCCCGCCGCCGGGTGGCCCTCCGCCCTCGAGCATCAACAACAACCCGAACCCCACCTCGAACGGCGGCAGCATGAGCCCGCTGGCCAGATCCGCCTACACAATGAACAGCATGGGCATCCCGGTGGGCGGCATGTCCTCGGTGTCGCCCCAGGCGGCGGCCACCTTCGGCTCCAGCGTGCTCGACTCGGCGGCGGTGGCCAGCATGACCGGCAGCATGGGAGCGGCGGCCATGAACTCGATGGGCGGCAACTGCATGACCCCCAGCTCCATGAGCTACGCCAGCATGGGCTCCCCACTCGGCAACATGGGCGGCTGCATGGCCATGTCGGCTGCCAGCATGTCGGCGGCGGGACTGAGCGGCAACTACGGACCCATGCCGCCGGGATCGCGCGAAATGGAGACGGGCTCGCCCAACTCGCTGGGCAGATCGCGTGTGGACAAGCCGACGACCTACAGACGCAGCTACACGCACGCCAAGCCGCCGTACAGCTACATCTCCCTGATTACGATGGCCATACAGAACAACCCGACGCGGATGCTCACGCTGTCGGAGATCTACCAGTTCATCATGGACCTGTTCCCCTTCTACAGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGAGCTTCAACGACTGCTTCGTGAAGATACCGCGGACGCCCGACAAGCCCGGCAAGGGCTCCTTCTGGACGCTGCATCCCGACTCCGGGAACATGTTCGAGAACGGCTGCTACTTGCGGCGGCAGAAGCGCTTCAAGGACGAGAAGAAGGAGGCCATTCGGCAGCTGCACAAGAGTCCGTCGCACAGCAGCCTGGAGGCGACCAGTCCGGGCAAGAAGGACCACGAGGACTCGCACCACATGCACCACCATCACCACAGCCGACTGGAGCACCACCAGCACCACAAGGAAGCGGGCGGCGCCTCTCTGGCCGGCGTGAATGTGTTGAGTGCGGCGCACAGCAAGGACGCGGAGGCCCTGGCCATGCTGCATGCCAACGCGGAGCTGTGCCTGGGCCAGCAGCCACAGCACGTGCCGACGCACCACCACCACCAGCACCACCAGCTGCAGCAGGAGGAGCTGTCGGCCATGATGGCCAACCGGTGCCACCCGTCGCTGATCAGCGACTACCACTCCTCGATGCATCCACTGAAACAGGAGCCCTCCGGCTACACTCCCTCCAGCCACCCGTTCTCCATCAACCGCCTGCTGCCCACGGAGTCCAAGGCGGACATCAAGATGTACGACATGAGCCAGTACGCCGGCTACAACGCCCTCAGCCCGCTGACCAACTCACACGCTGCCTTAGGCCAGGACTCGTACTACCAGAGCCTCGGCTACCATGCGCCCGCCGGCACTACGAGCTTCGACCTCAGCGAGGAGCAACTGCAGCACCAGGCGGCCCAGCAGCAGTACAACAACTACCAGCAGTACGCGGCGGCCGCCAGCTACCGGAACTGGAATCACAGCCTCACGTTCAATGGAGCCGCCGCTCTGCAGAACCTCCTGTAG
Protein Sequence
MQKLYAEPPPSSGAPVSMSSGGGPPPGGPPPSSINNNPNPTSNGGSMSPLARSAYTMNSMGIPVGGMSSVSPQAAATFGSSVLDSAAVASMTGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGNYGPMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHSRLEHHQHHKEAGGASLAGVNVLSAAHSKDAEALAMLHANAELCLGQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLISDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSFDLSEEQLQHQAAQQQYNNYQQYAAAASYRNWNHSLTFNGAAALQNLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00615394; iTF_00477154; iTF_00487814; iTF_00475751; iTF_00565895; iTF_00481360; iTF_00538771; iTF_00545779; iTF_00579795; iTF_00550068; iTF_00505210; iTF_00503804; iTF_00578333; iTF_00614719; iTF_00503073; iTF_00511813; iTF_00616711; iTF_00554889; iTF_00587945; iTF_00494193; iTF_00603891; iTF_00529373; iTF_00618173; iTF_00915138; iTF_00917878; iTF_00919672; iTF_00495667; iTF_00617443; iTF_00524228; iTF_00612622; iTF_00565188; iTF_00531493; iTF_00590058; iTF_00601573; iTF_00585769; iTF_00605381; iTF_00916037; iTF_00338950; iTF_00533607; iTF_00584988; iTF_00542951; iTF_01319560; iTF_00530761; iTF_00359275; iTF_00804194; iTF_00582071; iTF_00523499; iTF_00611874; iTF_00918859; iTF_00486380; iTF_00515404; iTF_00504493; iTF_00607620; iTF_00592199; iTF_00539467; iTF_00596462; iTF_00591509; iTF_00602391; iTF_01555245; iTF_01558838; iTF_00901294; iTF_01553774; iTF_01551529; iTF_01550800; iTF_00589359; iTF_00483492; iTF_00555650; iTF_00500847; iTF_00577586; iTF_00600119; iTF_00590776; iTF_00595054; iTF_00470671; iTF_00568780; iTF_00478524; iTF_00570942; iTF_00604655; iTF_01559567; iTF_01550085; iTF_01554495; iTF_00526384; iTF_00562986; iTF_00606128; iTF_00479982; iTF_00492032; iTF_00480690; iTF_00517520; iTF_00473591; iTF_00471417; iTF_00484255; iTF_00580514; iTF_00914308; iTF_00487115; iTF_00917006; iTF_00574616; iTF_00336531; iTF_01552979; iTF_00518965; iTF_00579093; iTF_00535863; iTF_00514697; iTF_00474318; iTF_00603158; iTF_00600862; iTF_00608248; iTF_00557712; iTF_01548664; iTF_01552261; iTF_00335674; iTF_00337322; iTF_00338135; iTF_01557370; iTF_00581339; iTF_00593659; iTF_00528604; iTF_00522761; iTF_00575382; iTF_00610454; iTF_00583484; iTF_00608988; iTF_01556636; iTF_00505917; iTF_00536573; iTF_00507422; iTF_00547871;
90% Identity
iTF_00587208;
80% Identity
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