Drel010637.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila repletoides
Gene Symbol
fkh
Assembly
GCA_018150835.1
Location
JAECWQ010000100.1:6937247-6939274[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.7e-40 6.2e-37 125.5 0.1 2 88 187 272 186 272 0.98

Sequence Information

Coding Sequence
ATGCAAAAGCTCTATGCTGAGCCACCGCCCAGCAGTGCGCCGGTCAGCATGTCCAGCGCTGGCGGCCCACCAACGAGCGGCGGCGGTGGCGGTGGTGCAGTCCCAACCAGCAACAACAATCCCAATCCCACCTCCAATGGCGGCAGCATGAGTCCACTGGCGCGCTCCGCATACACCATGAATAGCATGGGTCTCACAGTGGGTGGCATGTCTTCAGTGTCGCCCCAAGCGGCAGCCACTTTCGGCTCCAGCGTACTGGACTCTGCGGCCGCCGTGGCCAGTATGAGCGGCAGCATGGGCGCCTCAGCAGCCATGAATTCAATGGGCGGCAATTGCATGACGCCCAGTTCGATGAGCTATGCAAGCATGGGTTCGCCTCTGGGCAATATGGGTGGCTGCATGGCCATGTCGGCGGCAAGCATGTCTGCAGCAGGTTTGGGTGGCAGCTATGGTTCCATGCCACCAGGTCCACGTGATATGGAGACTGGTTCACCAAATTCATTGGGGCGACGTGGCGTGGACAAACCCACAACATACAGGCGCAGCTATACACATGCCAAGCCACCATATAGCTATATATCGTTGATCACGATGGCCATACAGAATAATCCGACACGCATGCTGACTCTGTCAGAGATCTATCAGTTCATCATGGATTTGTTTCCGTTCTATCGACAGAATCAGCAGCGCTGGCAGAACTCCATACGTCATTCGCTGAGCTTCAACGATTGCTTTGTGAAGATTCCACGCACGCCGGACAAGCCGGGTAAAGGTTCGTTCTGGACGTTGCATCCGGATTCGGGCAACATGTTTGAGAATGGCTGCTATTTGCGGCGACAAAAACGTTTCAAGGATGAGAAGAAGGAGGCCATCAGGCAACTGCATAAGAGTCCGTCGCACAGCAGCTTGGAGGCGACCAGTCCGGGCAAAAAGGATCACGAAGATTCGCATCATATGCATCATCATCATCACACGAGTCGCCTGGAGCATCATCAGCATCACAAGGAATCGGGCGGCGGTGGTGGTGTGGCGCTGGCGGGCGTCAATGTCCTTAGTGCAGCGCACAGTAAGGATGCCGAAGCGCTGGCCATGCTGCATGCCAATGCAGAGCTTTGCCTGGGGCAACAGCCACAGCATGTGCCCACGCATCACCATCATCAGCACCATCAGCTGCAGCAGGAGGAACTGTCGGCGATGATGGCCAATCGTTGCCATCCGTCGCTGATCAGCGATTATCACTCGTCGATGCATCCACTGAAACAGGAGCCCTCCGGCTACACGCCCTCCAGCCATCCGTTCTCCATCAATCGCCTGCTGCCCACAGAGTCCAAGGCGGACATTAAAATGTATGATATGAGCCAGTATGCTGGATATAATGCGCTCAGTCCGCTGACCAACTCACACGCTGCCTTAGGCCAGGACTCCTATTACCAGAGTCTTGGTTACCATGCGCCTGCCGGAACCACGAGCTTCGCCGCCGCATTGCAGAATTTGCTGTAG
Protein Sequence
MQKLYAEPPPSSAPVSMSSAGGPPTSGGGGGGAVPTSNNNPNPTSNGGSMSPLARSAYTMNSMGLTVGGMSSVSPQAAATFGSSVLDSAAAVASMSGSMGASAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLGGSYGSMPPGPRDMETGSPNSLGRRGVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHTSRLEHHQHHKESGGGGGVALAGVNVLSAAHSKDAEALAMLHANAELCLGQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLISDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSFAAALQNLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00512527;
90% Identity
iTF_00492770; iTF_00611874; iTF_00503073; iTF_00554889; iTF_00603891; iTF_00570942; iTF_00483492; iTF_00555650; iTF_00500847; iTF_00577586; iTF_00590776; iTF_00523499; iTF_00618173; iTF_00615394; iTF_00477154; iTF_00487814; iTF_00475751; iTF_00565895; iTF_00481360; iTF_00538771; iTF_00545779; iTF_00579795; iTF_00550068; iTF_00503804; iTF_00614719; iTF_00508129; iTF_00559299; iTF_00476430; iTF_00509625; iTF_00554202; iTF_00546462; iTF_00568062; iTF_00611205; iTF_00916037; iTF_01550085; iTF_01552261; iTF_00510344; iTF_00537314; iTF_00557712; iTF_00608248; iTF_00583484; iTF_00518965; iTF_01549384; iTF_00506665; iTF_00601573; iTF_00511081; iTF_01551529; iTF_01550800; iTF_00540173; iTF_00901294; iTF_01553774; iTF_00470671; iTF_00568780; iTF_00478524; iTF_00512527; iTF_00493453; iTF_00589359; iTF_01559567; iTF_00526384; iTF_00562986; iTF_00803408; iTF_00804992; iTF_00480690; iTF_00517520; iTF_00473591; iTF_00471417; iTF_00484255; iTF_00514697; iTF_00487115; iTF_00600862; iTF_01322450; iTF_00558465; iTF_00548611; iTF_00566595; iTF_00573123; iTF_00592899; iTF_00494916; iTF_00521156; iTF_00524932; iTF_00545028; iTF_00472870; iTF_00497190; iTF_00616006; iTF_00597960; iTF_00527851; iTF_00519724; iTF_00541580; iTF_00564460; iTF_00549358; iTF_00597166; iTF_00560047; iTF_00560847; iTF_01323919; iTF_00496400; iTF_00567344; iTF_00532177; iTF_00495667; iTF_00482037; iTF_00544277; iTF_01320277; iTF_00521974; iTF_00586486; iTF_00609686; iTF_00572407; iTF_00582071; iTF_00502329; iTF_00606873; iTF_00530074; iTF_00573853; iTF_00599389; iTF_01325470; iTF_00516063; iTF_00547167; iTF_01321727; iTF_00551392; iTF_00598688; iTF_00513986; iTF_00497958; iTF_00542247; iTF_00501610; iTF_00582767; iTF_00513266; iTF_00576151; iTF_00557020; iTF_00516800; iTF_00499395; iTF_00518250; iTF_00595757; iTF_00565188; iTF_01324709; iTF_00616711; iTF_00552840; iTF_00576877; iTF_00508910; iTF_00613998; iTF_00520439; iTF_00595054; iTF_00805774; iTF_00535119; iTF_00802640; iTF_00500113; iTF_01323187; iTF_00498676; iTF_00552114; iTF_00831956; iTF_00538038; iTF_01326200; iTF_00553562; iTF_00562277; iTF_00472171; iTF_00556364; iTF_01326972; iTF_00543549; iTF_00570205; iTF_00485667; iTF_00619647; iTF_01327698; iTF_01320999; iTF_01552979; iTF_00579093; iTF_00603158; iTF_00610454; iTF_00533607; iTF_00584988; iTF_00585769; iTF_00575382; iTF_00522761; iTF_00528604; iTF_01558838; iTF_00584237; iTF_01555245; iTF_00535863; iTF_00574616; iTF_00580514; iTF_00919672; iTF_00915138; iTF_00914308; iTF_00918859; iTF_00917006; iTF_00917878; iTF_01548664; iTF_01557370; iTF_01555931; iTF_00490588; iTF_00530761; iTF_01556636; iTF_00505917; iTF_01554495; iTF_01355936; iTF_01570048;
80% Identity
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