Dsub004999.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila subobscura
Gene Symbol
ZNF296
Assembly
GCA_008121235.1
Location
NC:7682334-7687061[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 26 0.00046 0.027 14.5 1.1 1 23 212 234 212 234 0.97
2 26 0.04 2.3 8.4 1.5 1 23 240 262 240 262 0.97
3 26 0.044 2.6 8.3 2.4 2 23 294 315 293 315 0.97
4 26 0.00054 0.032 14.3 2.9 1 23 388 411 388 411 0.94
5 26 3.7 2.2e+02 2.2 2.0 2 22 419 439 418 439 0.95
6 26 0.46 27 5.0 1.5 1 23 448 470 448 470 0.97
7 26 0.2 12 6.2 0.4 3 23 482 502 480 502 0.96
8 26 0.066 3.9 7.7 0.9 1 23 583 606 583 606 0.97
9 26 0.02 1.2 9.3 0.1 2 22 616 636 613 636 0.90
10 26 0.061 3.6 7.8 2.7 1 23 645 668 645 668 0.96
11 26 0.00098 0.058 13.4 1.6 2 23 696 717 695 717 0.97
12 26 1.6e-05 0.00095 19.1 2.9 1 23 725 747 725 747 0.98
13 26 0.0013 0.078 13.0 0.9 1 23 895 918 895 918 0.95
14 26 0.012 0.7 10.0 0.3 2 22 926 946 925 946 0.94
15 26 0.006 0.35 11.0 1.2 1 23 955 978 955 978 0.97
16 26 3e-05 0.0018 18.2 1.5 2 23 999 1020 998 1020 0.97
17 26 0.00012 0.0073 16.3 1.2 1 23 1027 1049 1027 1049 0.98
18 26 0.0079 0.47 10.6 0.1 2 23 1076 1097 1075 1098 0.94
19 26 0.01 0.62 10.2 3.9 1 23 1137 1160 1137 1160 0.96
20 26 0.0089 0.53 10.4 0.3 1 23 1197 1220 1197 1220 0.96
21 26 0.00025 0.015 15.3 1.5 1 23 1245 1268 1245 1268 0.97
22 26 4.8e-06 0.00028 20.7 0.2 2 23 1294 1315 1293 1315 0.95
23 26 0.00013 0.0078 16.2 2.9 1 23 1321 1343 1321 1343 0.99
24 26 3.2e-06 0.00019 21.3 2.0 1 23 1349 1371 1349 1371 0.97
25 26 1.7e-07 9.8e-06 25.3 2.4 1 23 1377 1399 1377 1399 0.99
26 26 0.0011 0.066 13.3 0.1 1 21 1405 1425 1405 1429 0.91

Sequence Information

Coding Sequence
ATGCTGCCCAGCAATATTTGCCGTACGTGTGCCGTGCAGAACAACAATTTGCTGCCCCTGTCCACTTCATTGGACAAGCACACGAACAAAAGTTTCTATGATGCGCTCCAAGAACTGACGCAGATCGATCCTCTGCTGGAGCATGCTGACGATAATCTGCCCCAGCATCTGTGCGCAGATTGCTTGGACAGGCTGGAAAACGCGTACGCCTTTGTGGAGCAGGCCAGAAAAGTCAATGGGGAGCTGCTGGTACGGCTGAGGGAATGTCTGGAGGAGAGCCCCATTGACATACCACAGCGGCAGATTAAAACAGAGATCGACATTGATGAGGAGCAACGAGACTTTACTGATTCTGGGGATCCACAAAGATCGTCAGATGTGGATTTGGAGTCGGCCGGCGTGTGCTCCGTTGAGTTCAAATGGACCCCAGAGAGCGATGCGCTCTCAAACGATGAAGATGAAGACGTGGATAAGCAGCAGTCGTACACCTTGCGGCGAAGTTCTCGCATAGTCAAGCAACAGCCGGACAGtgaagaggaggaaggagaagGAGGCAATCCATCACCCAATAAGCGGCGTCGTGGCCGTCCACCTGGTCTGGCCAAAAGCCAATCCAGGAATTCCGAAGGCCGTCATGTCTGTGAGGTGTGTGGCAAGACGTTTTCCTGGTACCGGGACATGAAGCGGCATGCGCGCATCCACTACGAGAAAGCCTCGTTCGTCTGCGACACCTGCGGCAAGGGATTCCTGCGCAAGGACAAGTACATGTTCCATCTGCGCTCCCACGAGAAGCGAGAGGCCAAGTGCCAGGCCCTCCAGCTGAAGAACGTGTGGAGATACGCCGAGCGGTTGTACAACTCTGGTCGGCTGAAGAGAATGCAGTGCAAATTGTGTGGCCTGAAGTGCCAGCGAATGCAGGAGCTGCGATCCCATTTGGAGAGTCACACTCGCACGGACAGTTTGTTCAGTCTGCGTGCGGACAGCGATGTGGTCAAGGAACACTTTGCCAGGGTGCCATTGGAACTGGAAAAGATCAAGGAACAAGTGTGCTCGGAAATAGCCGCAGGGCTGCTGGAGAAGTACTCTTGTGTCGTCAACTTCCATGGATACGAACTGTGCCTGAGCGATTCAGACGATGAGCCGGCCGGTGGAGAGCCACCGTATCACTGTGACCTGTGCAATCTTTCGTTCACTCGGAAATATCGCCTGATGCGTCACACACTGGAGGAGCACAGCCAATCGCCCATTGCCCAGCGCTGCAGCCTCTGCAAAGTGGGTTTCGTGTGTGCAAAGCTCTTTAAGCAGCACCAGCGCACCCAGTGCCAGAGCAAAGTGAAGCGCTATCGCTGCCGCAAGTGTCCGGGGAAGTTCATGTGGCTGGAGAATCTGGAGCGGCATGCCTGCTCCCATCGCAGGGAGGAGCAGTCATACAGGCAAATCATCTGCTGCCTGTGCGACGCACAGTTGCCCAGCTTGAGGCAGCTGCGCACCCACCTGGCCACCCATGGACATGGATTGAGTGGCATTGATCCGGAGCAGAGGTCTGCCTTCTTCCGATCTTACTATCCCAATGGGTTGAGTTGCAGCCTCTCCGAGCTAAGCTCCCGCATAGCTGCTGACTACGAGGCCCAAGACTTTGGACGCTACTACAACGCCTGCACGGGAAGTGGTCAAGAGCTGGATCTCTTCGACTCCGACACGGATGAGAGCGATGCAGACAAAACAGAGGGAAAGCCAAAACCCTCGCACACCTGCCTGCTGTGTGGAGAGACTGCCGATCGTCTGCTCAAGCTGCTGCAACATCAGAGGAGACTCCACTCCGAAGAGGGCACCACTTATCCCTGCTCTTGCGAGGGGTGTGGAGCTGGCTTCGTGTCCGATCCCTTGCTGCAGCAACATCGCAGACGTTCCTGTGCCAAAAAGCACTCGAATTACAACTGCCAGCGATGCAATCTTCATTTCGTGTGGCAATCAAACTACGAGCAACATCTGCGATTGTATCACaacaagcaggagcaggatcaGGAGCAGTCGGAGGACTGCCAGCAGGCtatacataaacacaaatcCCCACCCGCCAAGCTGCAGTGCGATGAATGTGAAAAGGTCTTCATTTGGCACAAGGATCTCACGCGGCACAAGCGAATGCATCGTCCTACGTCGGCAGCCCAATTTGAGTGTGCCTTCTGCGATCGCAAGTTCCATCGCAAGGATGGCCTCAAGTCCCACATGCGGGTGCACAACgagcaagagcaggaggcGGCTGTCAGTGAGGAGCAACCTTCTACGAACAGTATTCAACGAATGCCACGGGAGAAGCTGTCCCAACTCTGCCGTCCAAATGGCTGCAAGCTAATTCAGTGCATGATTTGCCTCTCGCGCCACTCGAAGATTGCCGATTTAAGGACACATCTAGGCGGCCATCAGTATGGAGTGAGCTTTACACAGGAGAGAGATATTGCCAGTGCCTCGCGCTCATTGTATCCGGAACTAAGCACTgccatggagcagcaggagctggtggAGCGAATCATGAGCGATGTGGCTAGCGGCGTGGAGTTGGAGCGATTTATTTCCATAACCAACGAGGCTGGCATTGAGCTCTCGCTGGAGAGCAgcgaaacggaaacggatTCAGAGCAGGAGGATGACGAGAGCTGCGAGGAAGCGGACCAGCAGCGGTACGTCTGCAACATATGCCAGTTGGAGGTGCGGCGAAAGCATCAATTGTATGCCCACCAGTTGGAGCAACACCAGTGGGAGGATGCGTTGCTTGAGTGCGCCCATTGTCAGGCGAGATTCGTCAGTGAGGCGCTGCTGGAGCATCACTACAGATCCCTCTGCCGGAACCCACAGAAGCGTTTCCAGTGCCGCAAGTGCCCGCTACGCTTCCGCTGGCGGGAGAACCTAAAGCTGCACGTCAGCACCTCCCATCAGCAAAAGGAACTGCCCCCAGCTGGGGAGGAACCCAGAATCCAATCAGAATTCGAGCTGCAGTGTGGAGAGTGCAAGCGCAGCTTCAAGATGCAGAAAGATCTCACGCGGCACACGCTGATGCATGCCCAGGAATCGAGCATTTATCGCTGTCGGTGGTGTGCCCGCCGCTTCTACCGGAAGGCAAATCTCCTGCAGCACATCGAGCGGCACGGCATCGGCGCTAGCCAGCTGTCCTACGCGGAAGCACTCCTCGATGCCTATGGCCATGCCAATGGCCAGAAGTGCGTGGAGTGCAAAGTGTGCAGCCTGAGCTTCCCCAGCATCGCTGCCCTTCGCATTCACCTGGGCAGTCACCACGAACTCACGTCCCTGCAGAACTACTCGATAACCAACCAACTGGGATTCGAGCTGGACTTGAATGACTCGGAGACGGATGAAGGGGAGTCCAAGCCAGCGGGCACGCCTGCCTTCTACACCTGTGGCATGTGCCAACTGCGGTGTGTGCGAAAGTACGAGctgcatcagcaccagcaggcCATGCACAGGCTGGAGAAGATACCCGATGGCTGCGATCGGTGCATCTTTAAGAGCGTCTCTCCCGATCTGATCGCGCACCACAAGCGCGTGCAGTGCCACAACCAGGAGAAGCAATTCACCTGCGCCAACTGCGGCTACAAGTTCATGTGGGAGtccaatctgctgctgcacatgcagctgcaacatggAAAGACagaggaacaggaacaggatcCACCCCGAGAGGAGACCGCGGAGCAGAAGACTGTGTGCCAAATCTTTCAGTGCGGCCTCTGCCCGAGGAAGTACAATCGAAAGGATCGTCTGACGGCGCATGTGAAGAAGTTCCACAACCCAGTGGTGGGGGCTCCAAGCGCCACACGGCCTCCCATCCGACCAGCGTCACCTAAGGAGCCGAAACGATTCCTTTGCGCCTTCTGTGGCAAGGCTGTGAGCTCCTCCTCTAACCTCATCATCCACATGCGACGGCACACCGGCGAGAAGCCCTTCAAGTGCGACTACTGCGAAATGGCCTTCCCTCGCTCCTCCGATCTCCAGTGCCATCGACGAACGCACACCGGCGAGCGGCCCCACATCTGCACCGTCTGCCAGAAGGGCTTCGCCAGATCctacaagctgcagcagcacatgcgCATCCACAACGGCGAACGGCCCTACAAGTGCACCTACTGCGAGAAGAGCTTCACCCAGTCCAACGACCTGACGCTCCACATCCGCCGCCACACCGGCGAGCGTCCCTATCAGTGTGGCGTCTGTGGTGAGCGTTTCATACAGGGCACTGCCCTGAAGAACCATCGACTGCAGCAGGGACACTGTGACGAGGCCAGCCAAGAGGGTGCAGAGTCCTCAAGGCGCACGGTCCTCGAGCAATTTACAGTCTAG
Protein Sequence
MLPSNICRTCAVQNNNLLPLSTSLDKHTNKSFYDALQELTQIDPLLEHADDNLPQHLCADCLDRLENAYAFVEQARKVNGELLVRLRECLEESPIDIPQRQIKTEIDIDEEQRDFTDSGDPQRSSDVDLESAGVCSVEFKWTPESDALSNDEDEDVDKQQSYTLRRSSRIVKQQPDSEEEEGEGGNPSPNKRRRGRPPGLAKSQSRNSEGRHVCEVCGKTFSWYRDMKRHARIHYEKASFVCDTCGKGFLRKDKYMFHLRSHEKREAKCQALQLKNVWRYAERLYNSGRLKRMQCKLCGLKCQRMQELRSHLESHTRTDSLFSLRADSDVVKEHFARVPLELEKIKEQVCSEIAAGLLEKYSCVVNFHGYELCLSDSDDEPAGGEPPYHCDLCNLSFTRKYRLMRHTLEEHSQSPIAQRCSLCKVGFVCAKLFKQHQRTQCQSKVKRYRCRKCPGKFMWLENLERHACSHRREEQSYRQIICCLCDAQLPSLRQLRTHLATHGHGLSGIDPEQRSAFFRSYYPNGLSCSLSELSSRIAADYEAQDFGRYYNACTGSGQELDLFDSDTDESDADKTEGKPKPSHTCLLCGETADRLLKLLQHQRRLHSEEGTTYPCSCEGCGAGFVSDPLLQQHRRRSCAKKHSNYNCQRCNLHFVWQSNYEQHLRLYHNKQEQDQEQSEDCQQAIHKHKSPPAKLQCDECEKVFIWHKDLTRHKRMHRPTSAAQFECAFCDRKFHRKDGLKSHMRVHNEQEQEAAVSEEQPSTNSIQRMPREKLSQLCRPNGCKLIQCMICLSRHSKIADLRTHLGGHQYGVSFTQERDIASASRSLYPELSTAMEQQELVERIMSDVASGVELERFISITNEAGIELSLESSETETDSEQEDDESCEEADQQRYVCNICQLEVRRKHQLYAHQLEQHQWEDALLECAHCQARFVSEALLEHHYRSLCRNPQKRFQCRKCPLRFRWRENLKLHVSTSHQQKELPPAGEEPRIQSEFELQCGECKRSFKMQKDLTRHTLMHAQESSIYRCRWCARRFYRKANLLQHIERHGIGASQLSYAEALLDAYGHANGQKCVECKVCSLSFPSIAALRIHLGSHHELTSLQNYSITNQLGFELDLNDSETDEGESKPAGTPAFYTCGMCQLRCVRKYELHQHQQAMHRLEKIPDGCDRCIFKSVSPDLIAHHKRVQCHNQEKQFTCANCGYKFMWESNLLLHMQLQHGKTEEQEQDPPREETAEQKTVCQIFQCGLCPRKYNRKDRLTAHVKKFHNPVVGAPSATRPPIRPASPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDYCEMAFPRSSDLQCHRRTHTGERPHICTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRLQQGHCDEASQEGAESSRRTVLEQFTV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00580900;
90% Identity
iTF_00515025;
80% Identity
-