Basic Information

Insect: Drosophila guanche
Gene Symbol: Znf296
Assembly: GCA_900245975.1
Location: NW:4638498-4643222[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 26 0.00047 0.027 14.5 1.1 1 23 231 253 231 253 0.97

2 26 0.028 1.6 8.9 1.7 1 23 259 281 259 281 0.97

3 26 0.005 0.29 11.2 2.4 2 23 313 334 312 334 0.97

4 26 0.0022 0.13 12.3 2.8 1 23 407 430 407 430 0.94

5 26 4.5 2.6e+02 1.9 2.0 2 22 438 458 438 458 0.95

6 26 0.46 27 5.0 1.5 1 23 467 489 467 489 0.97

7 26 0.2 12 6.2 0.4 3 23 501 521 499 521 0.96

8 26 0.023 1.4 9.1 2.6 1 23 602 625 602 625 0.97

9 26 0.016 0.94 9.6 0.1 2 22 635 655 632 655 0.90

10 26 0.14 8.2 6.7 6.6 1 23 664 687 664 687 0.97

11 26 0.00088 0.052 13.6 2.0 2 23 714 735 713 735 0.97

12 26 1.6e-05 0.00096 19.0 2.9 1 23 743 765 743 765 0.98

13 26 0.012 0.73 10.0 1.8 1 23 913 936 913 936 0.95

14 26 0.012 0.7 10.0 0.3 2 22 944 964 943 964 0.94

15 26 0.021 1.3 9.2 0.7 1 23 973 996 973 996 0.92

16 26 3e-05 0.0018 18.2 1.5 2 23 1017 1038 1016 1038 0.97

17 26 0.00012 0.0073 16.3 1.2 1 23 1045 1067 1045 1067 0.98

18 26 0.0022 0.13 12.3 0.2 2 23 1094 1115 1093 1116 0.94

19 26 0.01 0.62 10.2 3.9 1 23 1155 1178 1155 1178 0.96

20 26 0.063 3.7 7.7 0.2 1 23 1215 1238 1215 1238 0.94

21 26 0.00025 0.015 15.3 1.5 1 23 1263 1286 1263 1286 0.97

22 26 4.8e-06 0.00028 20.7 0.2 2 23 1313 1334 1312 1334 0.95

23 26 0.00013 0.0079 16.2 2.9 1 23 1340 1362 1340 1362 0.99

24 26 3.2e-06 0.00019 21.3 2.0 1 23 1368 1390 1368 1390 0.97

25 26 1.7e-07 9.9e-06 25.3 2.4 1 23 1396 1418 1396 1418 0.99

26 26 0.0011 0.067 13.2 0.1 1 21 1424 1444 1424 1448 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	26	0.00047	0.027	14.5	1.1	1	23	231	253	231	253	0.97
2	26	0.028	1.6	8.9	1.7	1	23	259	281	259	281	0.97
3	26	0.005	0.29	11.2	2.4	2	23	313	334	312	334	0.97
4	26	0.0022	0.13	12.3	2.8	1	23	407	430	407	430	0.94
5	26	4.5	2.6e+02	1.9	2.0	2	22	438	458	438	458	0.95
6	26	0.46	27	5.0	1.5	1	23	467	489	467	489	0.97
7	26	0.2	12	6.2	0.4	3	23	501	521	499	521	0.96
8	26	0.023	1.4	9.1	2.6	1	23	602	625	602	625	0.97
9	26	0.016	0.94	9.6	0.1	2	22	635	655	632	655	0.90
10	26	0.14	8.2	6.7	6.6	1	23	664	687	664	687	0.97
11	26	0.00088	0.052	13.6	2.0	2	23	714	735	713	735	0.97
12	26	1.6e-05	0.00096	19.0	2.9	1	23	743	765	743	765	0.98
13	26	0.012	0.73	10.0	1.8	1	23	913	936	913	936	0.95
14	26	0.012	0.7	10.0	0.3	2	22	944	964	943	964	0.94
15	26	0.021	1.3	9.2	0.7	1	23	973	996	973	996	0.92
16	26	3e-05	0.0018	18.2	1.5	2	23	1017	1038	1016	1038	0.97
17	26	0.00012	0.0073	16.3	1.2	1	23	1045	1067	1045	1067	0.98
18	26	0.0022	0.13	12.3	0.2	2	23	1094	1115	1093	1116	0.94
19	26	0.01	0.62	10.2	3.9	1	23	1155	1178	1155	1178	0.96
20	26	0.063	3.7	7.7	0.2	1	23	1215	1238	1215	1238	0.94
21	26	0.00025	0.015	15.3	1.5	1	23	1263	1286	1263	1286	0.97
22	26	4.8e-06	0.00028	20.7	0.2	2	23	1313	1334	1312	1334	0.95
23	26	0.00013	0.0079	16.2	2.9	1	23	1340	1362	1340	1362	0.99
24	26	3.2e-06	0.00019	21.3	2.0	1	23	1368	1390	1368	1390	0.97
25	26	1.7e-07	9.9e-06	25.3	2.4	1	23	1396	1418	1396	1418	0.99
26	26	0.0011	0.067	13.2	0.1	1	21	1424	1444	1424	1448	0.91

Sequence Information

Coding Sequence: ATGCTGCCCAGCAATATTTGCCGTACGTGTGCAGTGCAGAACAACAATTTGCTGCCCCTGTCGACTTCCTTGGGCAAGCACACGAACAAAAGTTTCTATGATGTGCTCCAAGAACTGACGCAGATCGATCCACTGCTGGAGAATGCTGACGATAATCTGCCCCAGCACCTGTGCACAGACTGCTTGGAGAGGCTAGAGAACGCGTACGCCTTTGTAGAGCAGGCCAGAAAAGTCAATGGGGAGCTGCTGGTGCGGCTGAGGGAATGTCTGGAGGAAAGCCCCATTGACATACCACAGCAGCCGATTAAAACAGAGATCGACATTGATGAGGAGCAACGAGACTTCACTGATTCTGGGGATCCACAAAGATCGTCAGATGTGGATTTGGAGTCGGCTGGCGTGTGCTCTGTTGAGTTCAAATGGACGCCAGAGAGCGATGCGCTCTCAAACGAAGAGCGAGTAAATCAAATAACTAAAGAAACCCCttatttaattgttgcttTTCCCTGCAGGGATGAAGACGTGGATAAGCAGCAGGCGTACATCTTGCGGCGAAGTTCTCGCAAAGTTAAGCAACAGCCGGACAGTGAAGAGGAGGAAGGAGAAGGAGGCAATCCATCACCCAATAAGCGTCGTCGTGGTCGTCCTCCTGGTCTGGCAAAAAGCCAGTCAAAAAATGCCGAAGGCCGTCATGTCTGTGAGGTGTGCGGCAAGACGTTTTCCTGGTATCGGGACATGAAGCGGCATGCGCGCATCCACTACGAGAAAGCCGCGTTTGTCTGCGACACCTGCGGCAAGGGATTCTTGCGCAAGGACAAGTACACGTTCCATCTGCGCTCCCACGAGAAGCGAGAGGCCAAGTGCCAGGCCCTCCAGCTGAAGAACGAGTGGAGATACGCCGAGCGTTTGTACAACTCCGGTCGGCTGAAGAGAATGCAGTGCAAATTGTGTGGCCTGAAATGCCAGCGATTGCAGGAGCTGCGATCCCATATGGAGAGTCACACTCGCACGGACAGTTTGTTCAGTTTGCGTGCGGACAGCGATGTGGTCAAGGAACATTTTTCCAGGGTGCCATTGGAACTAGAAAAGATAAAGGAACAAGTGTGCTCGGAAATAGCAGCAGGGCAGCTGGAGAAGTACTCTTGTGTCGTCAATTTCCATGGTTACGAACTGTGCCTGAGCGATTCTGACGATGAGCCTGCCGGTGGAGAGCCACCGTATCACTGTGACCTTTGCAATCTGTCCTACACTCGGAAGTATCGCCTGATGCGGCACACCCTGGAGGAACACAGCCAGTCGCCCATTGCCCGGCGCTGCAGCCTCTGCAAGGTTGGCTTCGTGTGTGCAAAGCTCTTTAAGCAGCATCAGCGCACCCAGTGTCAGAGCAAAGTGAAGCGCTATCGCTGCCGCAAGTGTCCGGGGAAGTTCATGTGGCTGGAGAATCTGGAGCGGCATGCATGCTCCCATCGCAGGGAGGAGCAGTCATACAGGCAAATCATTTGCTGCCTGTGCGACGCACAGTTGCCCAGCTTGAGACAGCTGCGCACCCACCTGGCCACCCATCGACATGGATTGAGTGGCATTGATCCGGAGCAGAAGTCCGCCTTCTTTCGTTCTTACTATCCCAACGGGCTGGGTTGCAGCCTCTCCGACCTGAGCTCCCGCATAGCTGCCGAATATGAGGCCCAAGACTTTGGACGCTACTACAACGCCTGCACGGGAAGTGGTCAAGAGCTGGATCTCTTCGACTCCGACACAGAGGAGAGCGATGCAGACAAAATAGAGGGACGGACAAAACCCTCGCACACCTGCCTGCTGTGTGGAGAGACTGCCGATCGTCTGCATAAGCTGCTGCAACATCAGAGGAGACTCCACTCCGAAGAGGGCACCACTTATCCCTGCTCTTGCGAGGAATGTGGAGCTGGTTTCGTGTCCGATCCCTTGCTGCAGCAACATCGCAGACGTTCCTGTGCCAAAAAGCACTCGAAATACCACTGCCAGCACTGCAATCTTCATTTCGTGTGGCAATCCAACTACGAGCAACATCTTCGGTTGTATCACAACAAGCAGGATCATGATCAGGAGCACTCAGAGGACTGTCAGAAGAGTAGAACCCATAAATCTTCGCCCGCAGAGCTGCAATGCAATGAATGCGAAAAGGTCTTCATTTGGCACAAGGATCTCACGCGGCACAAGCGAATGCATCGTCCTACGTCGGCAGCGCAATTTGAGTGTGCCTTCTGTGACCGCAAGTTTCATCGCAAGGATGGCCTCAAGTCGCACATGCGGGTGCACaatgagcaggagcaggaggcggcTGTCAGTGAGGAGCAACCTCCTACGAACAGTATTCAACGAATCACACGGGAGCAGCTGTCACAACTCTGCCGTCCAAATGGCTGCAAGCTAATTCAGTGTATGATTTGCCTCTCGCGACACTCGAAGATTGCCGATTTAAGGACACACCTAGGCTCGCACCAGTATGGAGTGAGCTTTACACAGGAGAGGGATATTGCCAGTGCCTCGTGCTCATTGTATCCGGAACTGGTCACTGCCATGGATCAGCAGGAGCTGGTGGAGCGAATCATGAGCGATGTGGCTAGCGGCGTGGAGTTGGAGCGATTTGTTTCCATAACCAACGAGGCTGGCATTGAGCTCTCGCTGGAGAGCagcgaaacagaaacggaTTCAGAGCAGGAGGATGACAAGAGCTGCGAGGAAGCGGACCAGCAGCGGTACGTCTGCAACATATGCCAGTTGGAGGTGCGACGAAGACATAAATTGTATACCCACCAGTTGGAGCAACATCAGTGGGAGGAGGCGCCGCTCGAGTGCGCCCATTGTCAGGCGAGATTCGTGAGTGAGGCGCTGCTGGAGCATCACTACAGATCCCTCTGCCGGAACCCACAGAAGCGTTTCCAGTGCCGCAAGTGCCCGCTACGCTTCCGCTGGCGGGAGAACCTAAAGCTGCATGTCAGCGCCTCTCATCAGCAAAAGGAAGTGCCCCCAGCTGGGGAGGAATCCAGCATCCAATTAGAATTCGAGCTGCAGTGTGGAGAGTGCAAGCGCAGCTTCAAGATGCAGAAAGATCTCACGCGGCACACGCTGATGCATGCCCAGGAATCGAGCATTTATCGGTGTCGTTGGTGTGCCCGCCGCTTTTACAGGAAGGCAAATCTCCTGCAGCACATTGAGCGGCACGGCATCGGGGCTAGCCAGCTGTCCTACGCGGAAGCACTCCTCGATGCCTATAGCCATGCCAATGGCCAGAAGTGCGTGGAGTGCAAAGTGTGCAGCCTGAGCTTCTCCAGCATCGCTGCCCTTCGCGTCCACCTGGGCAGTCACCACGAGCTCACGTCCCTGCAGAACTACTCGATAACCAACCAAATGGGATTCGAGCTGGACTTGAATGACTCGGAGACGGATGAAGGGGAGTCCAAGCCACCGGGCACGCCTGCCTTCTACACCTGTGGCATGTGCCAGCTGCGGTGTGTGCGAAAGTACGAGctgcatcagcaccagcaggccATGCACAGGCTGGAGAAGATACCCGATGGCTGCGATCGGTGCATCTTTAAGAGCGTCTCTCCCGATCTGATCGCGCACCACAAGCGCGTGCAGTGCCACAACCAGGAGAAGCAATTCACCTGCGCCAACTGCGGCTACAAGTTCATGTGGGAGtccaatctgctgctgcacgtgcagctgcagcatggaAAGACAGAGGAACAGGAAGAGCATCCACCCCAGGAGGAAACCACGGAGCAGAAGACTGTGTGCCAAATCTTTCAGTGCGGCCTCTGCCCCAGGAAGTACAATCGCAAGGATCGTCTGACGGCGCATGTGAAGAAGTTCCACAACCCAGTGGTGGGGACTCCAAGCGCCACACGGCCTCCCCCCATCCGACCAGCGTCTCCCAAGGAGCCGAAACGATTCCTTTGCGCCTTCTGTGGCAAGGCTGTGAGCTCCTCCTCCAACCTCATCATACACATGCGACGGCACACCGGCGAGAAGCCCTTCAAGTGCGACTACTGCGAAATGGCCTTCCCTCGCTCCTCCGATCTCCAGTGCCATCGACGAACGCACACCGGCGAACGGCCCCACATCTGCACTGTCTGCCAGAAGGGCTTCGCCAGATCCtacaagctgcagcagcacatgcGCATCCACAACGGCGAACGGCCCTACAAGTGCACCTACTGCGAGAAGAGCTTCACCCAGTCCAACGATCTGACGCTCCACATACGCCGCCACACCGGCGAGCGTCCCTATCAGTGTGGTGTCTGTGGCGAGCGCTTCATACAGGGCACTGCCCTGAAGAACCATCGACTGCAGCAGGGACACTATGACGAGGCCAGCCAAGAGGGTGCAGAGTCCTCAAGGCGCACGGTCCTAGAGCAATTTACAGTCTAG
Protein Sequence: MLPSNICRTCAVQNNNLLPLSTSLGKHTNKSFYDVLQELTQIDPLLENADDNLPQHLCTDCLERLENAYAFVEQARKVNGELLVRLRECLEESPIDIPQQPIKTEIDIDEEQRDFTDSGDPQRSSDVDLESAGVCSVEFKWTPESDALSNEERVNQITKETPYLIVAFPCRDEDVDKQQAYILRRSSRKVKQQPDSEEEEGEGGNPSPNKRRRGRPPGLAKSQSKNAEGRHVCEVCGKTFSWYRDMKRHARIHYEKAAFVCDTCGKGFLRKDKYTFHLRSHEKREAKCQALQLKNEWRYAERLYNSGRLKRMQCKLCGLKCQRLQELRSHMESHTRTDSLFSLRADSDVVKEHFSRVPLELEKIKEQVCSEIAAGQLEKYSCVVNFHGYELCLSDSDDEPAGGEPPYHCDLCNLSYTRKYRLMRHTLEEHSQSPIARRCSLCKVGFVCAKLFKQHQRTQCQSKVKRYRCRKCPGKFMWLENLERHACSHRREEQSYRQIICCLCDAQLPSLRQLRTHLATHRHGLSGIDPEQKSAFFRSYYPNGLGCSLSDLSSRIAAEYEAQDFGRYYNACTGSGQELDLFDSDTEESDADKIEGRTKPSHTCLLCGETADRLHKLLQHQRRLHSEEGTTYPCSCEECGAGFVSDPLLQQHRRRSCAKKHSKYHCQHCNLHFVWQSNYEQHLRLYHNKQDHDQEHSEDCQKSRTHKSSPAELQCNECEKVFIWHKDLTRHKRMHRPTSAAQFECAFCDRKFHRKDGLKSHMRVHNEQEQEAAVSEEQPPTNSIQRITREQLSQLCRPNGCKLIQCMICLSRHSKIADLRTHLGSHQYGVSFTQERDIASASCSLYPELVTAMDQQELVERIMSDVASGVELERFVSITNEAGIELSLESSETETDSEQEDDKSCEEADQQRYVCNICQLEVRRRHKLYTHQLEQHQWEEAPLECAHCQARFVSEALLEHHYRSLCRNPQKRFQCRKCPLRFRWRENLKLHVSASHQQKEVPPAGEESSIQLEFELQCGECKRSFKMQKDLTRHTLMHAQESSIYRCRWCARRFYRKANLLQHIERHGIGASQLSYAEALLDAYSHANGQKCVECKVCSLSFSSIAALRVHLGSHHELTSLQNYSITNQMGFELDLNDSETDEGESKPPGTPAFYTCGMCQLRCVRKYELHQHQQAMHRLEKIPDGCDRCIFKSVSPDLIAHHKRVQCHNQEKQFTCANCGYKFMWESNLLLHVQLQHGKTEEQEEHPPQEETTEQKTVCQIFQCGLCPRKYNRKDRLTAHVKKFHNPVVGTPSATRPPPIRPASPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDYCEMAFPRSSDLQCHRRTHTGERPHICTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRLQQGHYDEASQEGAESSRRTVLEQFTV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00580900;
90% Identity: iTF_00601189;
80% Identity: -