Basic Information

Insect: Drosophila sturtevanti
Gene Symbol: tfap2e_1
Assembly: GCA_018150375.1
Location: JAECWJ010000688.1:4018373-4026464[-]

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.8e-82 9.9e-78 260.4 0.1 1 196 240 433 240 434 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.8e-82	9.9e-78	260.4	0.1	1	196	240	433	240	434	0.98

Sequence Information

Coding Sequence: ATGGAAATTCCTAATAAATCTTATGAACTAAATAAAACGAAGATAGAACGCCTTAGTGGTCATGGGAGTCTAGGATTATCTAGCAGTAGTCCAGCATACACAACCCATTCAAGCGGGCACGTGGGTAGAGGCGGCCCGGCTTCCGGCCATAGTAATACTCATGGGTCGGCGGCAACGATGCATCATCAATCACTTCAGTCCGATTTTCAGCCTCCTTATTTTCCCCCACCTTTCCATCACTCTACGCAAAGCCCTCCTCAGCAACAGATGTCTGGATATTTACAGAATCATGGTGCACTTGAATATTTAGGCACAGATCCATATGGCCAGCCCTTATCATCATTACACCATGCGCCACTGCATCATTACAATCAGTTGGCAGGCCTAAGGTCGACACAAGATCAACTGGGAATTCACAGGACTCACAGAGAGGCTGAGCTACAGGGACATGTTACACAACTGTCTCACGGATTTCCATATACAGATAGAAGAAGTGATTACGGAACAGCATTATCAGCTGGAGCTGCCCATGGGACCAGGCTAGGCCACGAACATGAGTCCCTGGCGTTACATCAAGCCCTTCAAAATGCCGTTGATGATGTTCAAGCACCCGCACTTGACGATAACGTGGCGTTTATGTCAGATCTTCCTTTAATTAAAAGCATGAAAAGTGGGAAAGATGCCGCCAATATTGGCTCGGGTTCGCCTAGCGAAGTATTCTGTGCAGTTCCTGGTCGCCTTAGTCTTTTATCCAGTACATCGAAATACAAAGTCACAATTGCGGAAGTACAACGCAGGCTCTCACCGCCCGAATGCTTGAATGCATCCTTGCTGGGAGGAGTCCTTAGAAGAGCAAAAAGCAAGAACGGCGGACGGCTCTTAAGGGAAAAACTTGAAAAAATCGGCCTAAACTTACCAGCTGGCAGACGAAAAGCAGCAAATGTAACATTACTCACATCTTTAGTGGAAGGAGAAGCAACCCATTTAGCCAAGGACTTTCATTTTGTTTGCGAAACTGAATTCCCGGCGAGACAACTGGCCGAATACATTGTACGCCATCAAACAGAGCCCCAGGATTCCTACAGAAGGAAAGAACTTATTCTTCATTCGCAACAGATAACAAAAGAATTAATGCAGATCCTAAGCCAAGATAGAACCACACATTTTGGAACACGGTCACAGCATTTGTTAGAGCCGTCGATGCAACGACACTTGACACATTTCTCTTTAATAACACACGGGTTTGGTTCTCCTGCAATTATTGCAGTATTACATGCTTTTCAGGCATTTTTAAACGAATCGTTAAATTATTTGGAAAAACTTTATCCATCAAATGGAGGTGGAATGGTATCATCGTCCTTGGATAAAAGTAAAATTGACAACGATAAAAAATGA
Protein Sequence: MEIPNKSYELNKTKIERLSGHGSLGLSSSSPAYTTHSSGHVGRGGPASGHSNTHGSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQMSGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGTALSAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDLPLIKSMKSGKDAANIGSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIIAVLHAFQAFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNDKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00915904;
90% Identity: iTF_00598563;
80% Identity: iTF_00618023; iTF_00500717; iTF_00577453; iTF_00502929; iTF_00483358; iTF_00523358; iTF_00611742; iTF_00555520;