Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.6e-33 1.1e-29 103.7 4.9 89 170 67 148 57 150 0.94

2 3 9e-34 2.9e-30 105.7 1.9 200 299 150 245 148 246 0.98

3 3 0.18 5.7e+02 -0.4 3.5 218 241 272 295 248 320 0.50

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.6e-33	1.1e-29	103.7	4.9	89	170	67	148	57	150	0.94
2	3	9e-34	2.9e-30	105.7	1.9	200	299	150	245	148	246	0.98
3	3	0.18	5.7e+02	-0.4	3.5	218	241	272	295	248	320	0.50

Coding Sequence: ATGGCGGACTTGCCTAAAGATCGTGCACAGTGCTTACCAACATTCAAAGTCACTGGGATGGACTATTGTGGTCCTTTTTACTACAACGCTACTAACTTTGAACATCGCATTGAAGTTCATAGCTTCTGCATCAGCAACCGCTTTGATTGGAAGTTCATACCTTCACGTTCGCCACATTCCGGTGGCCTATGGGAAGCAGCAGTGAAGACCGCCGACGTCGAAGAACGTTTTCGAAAAGCCATGATAACGAATGCTCAACTAGACAATGATCGTTCATCACAAACCTATGAAGTTAAACTACTTAAAGATAAAAGTGAAGCGATGCAAGAATCTCTCGCTCAATTGCAACGcgaatttaaaaacaaactcCGCGATTGCAGTGCCCTTAAACGCAGCTTGGATCGCACAACACTTGAATTAAACCTAGTGCAAGGTCAACTAATAATGATGAAGCGCGCTCTGGTCAGTGTTGAAAACGCCAATGTGCTTTCAAGTGTTCAGGGTTCTCTTGatgTAAGAATTAACAAGTTTACAGAGGAAAAGCAGCGGCTTCTTAACGAAATGCAAAATCTGCGTGAACAGCTAGATGCTTTTAAAAATGAAGGCAGGCCAGGGCGAGACAGTCTACTAAGTGACTTTTTAGGGTACGATGATGACTATGATGCTCAGAgagaatcaaataaaatcatatcggattataaatataaactacaaAAAGCTGAACAGGAAATCGCAAGTCTTCAGGCAAACTTGGCGCGCTCAGAGACTCAAGTTATACGTTATAAAAGTACTGCTGAAGCTGCTGAAAAATCTGAGGCTGAACTGAAAGTAGAAAGACGTAAACTGCAACGTGAACACCGGGAGATTTTAGAACGTTTGGAGGAAGCAGAAACTGCCAATAATCATCTACTTAAACGActtgacaaattaaaaaatgcaaaaagcacAATTTTGAAAGATTTATGA
Protein Sequence: MADLPKDRAQCLPTFKVTGMDYCGPFYYNATNFEHRIEVHSFCISNRFDWKFIPSRSPHSGGLWEAAVKTADVEERFRKAMITNAQLDNDRSSQTYEVKLLKDKSEAMQESLAQLQREFKNKLRDCSALKRSLDRTTLELNLVQGQLIMMKRALVSVENANVLSSVQGSLDVRINKFTEEKQRLLNEMQNLREQLDAFKNEGRPGRDSLLSDFLGYDDDYDAQRESNKIISDYKYKLQKAEQEIASLQANLARSETQVIRYKSTAEAAEKSEAELKVERRKLQREHREILERLEEAETANNHLLKRLDKLKNAKSTILKDL

Sequence clustering based on sequence similarity using MMseqs2