Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:14546210-14551117[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.00014 0.0089 16.1 1.2 1 23 165 188 165 188 0.96

2 14 0.0015 0.091 12.9 3.1 2 23 237 259 233 259 0.90

3 14 0.0064 0.4 10.9 0.8 1 23 352 375 352 375 0.93

4 14 0.072 4.4 7.6 3.2 2 23 424 445 423 446 0.94

5 14 0.00058 0.036 14.2 0.4 1 23 516 539 516 539 0.92

6 14 1.7 1e+02 3.3 0.1 2 14 558 570 557 582 0.85

7 14 0.0011 0.071 13.2 5.6 2 23 590 611 590 612 0.95

8 14 0.0044 0.27 11.4 0.1 1 20 700 719 700 721 0.95

9 14 0.0015 0.089 12.9 0.3 1 23 753 776 753 776 0.93

10 14 0.002 0.13 12.5 1.5 2 23 826 848 825 848 0.95

11 14 0.016 0.97 9.7 1.8 1 23 945 968 945 968 0.91

12 14 0.011 0.67 10.2 1.0 1 21 1020 1040 1020 1041 0.95

13 14 5.7 3.5e+02 1.6 2.2 2 23 1072 1095 1071 1096 0.73

14 14 2.1 1.3e+02 3.0 0.1 1 13 1114 1126 1114 1130 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.00014	0.0089	16.1	1.2	1	23	165	188	165	188	0.96
2	14	0.0015	0.091	12.9	3.1	2	23	237	259	233	259	0.90
3	14	0.0064	0.4	10.9	0.8	1	23	352	375	352	375	0.93
4	14	0.072	4.4	7.6	3.2	2	23	424	445	423	446	0.94
5	14	0.00058	0.036	14.2	0.4	1	23	516	539	516	539	0.92
6	14	1.7	1e+02	3.3	0.1	2	14	558	570	557	582	0.85
7	14	0.0011	0.071	13.2	5.6	2	23	590	611	590	612	0.95
8	14	0.0044	0.27	11.4	0.1	1	20	700	719	700	721	0.95
9	14	0.0015	0.089	12.9	0.3	1	23	753	776	753	776	0.93
10	14	0.002	0.13	12.5	1.5	2	23	826	848	825	848	0.95
11	14	0.016	0.97	9.7	1.8	1	23	945	968	945	968	0.91
12	14	0.011	0.67	10.2	1.0	1	21	1020	1040	1020	1041	0.95
13	14	5.7	3.5e+02	1.6	2.2	2	23	1072	1095	1071	1096	0.73
14	14	2.1	1.3e+02	3.0	0.1	1	13	1114	1126	1114	1130	0.81

Sequence Information

Coding Sequence: ATGGAGGGCATGGATCTGTGGACGTCGATGTTTTCGTCCGACTTCGAGGAGGGTGAGGCGGAGAGCGGGGCGGCGGAACTGGAGGAAAGCGAGCAGTACGGGAATGGCAATGATGACTTCCTAGGCGATACGGAGATCCTTGATTCAGGCGATGCCATCGATGACCTGTTGGATGCCGAAGAGGATGAaagggaggaggaggatgactACGAAAAGAACTCCAAGGAGCCAAAGCAACCAGATCCCGACGATGATGCGCTCTTTGATTTTAATATGGAACCCATTGTTGATATAGCGGAGCCACAGCATCCGTCGTTGGCTCCTGCTGGACCCATGGGCCACCAAGTGCGTCCGCCAATGCAGCGACACTCATTCCCGGGAGCTGTGGGTCGACCTAGATTGGGTCCCGGTCTGTCTGTACGACCCACCACCTCGCAGATCAATGCAACGGACGAGAACGGAGTGCCAATTAACTACGAGTTGGGCGTAGTCTACATCTGCCCCGCCTGCGGTGGTGAATTCCGGCAACAGGACCACTGGAAGCGGCACATGAACCACATCCACAAATACAACACCCTGCGTGGCTTGAACTTTACGCCGCTGGACAAGCTCTATCAGCGGTGCAGGGAGTGCAACAAGCGGATTGCCATGCACAGCCGGGAGAACCTGCTTAAGCATAAGTTTACGCACCTGCCCTTCAGGTGCACCAAGTGCTACATCTGCAAGCGGGAGTACAAATACAGGCAAGATCTTATGGTTCATCTTCGCATGGTCCATTGCGATGAAGTCGTGGCCATGATGCGTGAGGGTTACAATGCGGCGGGGCGGAAGACACGGGTTCGAGAGTCTCGCACCGAGCAGCTGTTGCGGGAGAAGAGCTTCCGAGAGAATGATGACCTTGGGGAGGAATCCGATCGCATAGAGGTGCGGAATGAGCTGCTCGAGCCAGATGTTGATGAGTCTGGCATCCAGGAGCAGACCGTGTCGGAAGAGGTTTCCAAGAAAAAGGCTGGCACTCGAGGAGCAGCTGAACTGTGCGAGGATTACATACACTACATGTGTCCAGACTGCGGCACCGAATGCGACACTCACGCCCAATGGAGCCAGCACATCGAGTTCGTCCATGACTACGTCAGCCGAAGGGGACTTAATTTCCGAAGCGTGGACATGCAAATGCAGTGCCTCGAGTGCAAAAAGATTGTGACTCCCAACACCATTAAATCACTTCGCGCCCACAAATTCAGCCATTTATCGCAGCCTGAGTGGCTGCGCTGTAAACTCTGCTACAAGGGTTACACGGATCATCAGGAAATAATCAGACATCTGCTGCAGCACCATCATATGGATACGCTTATTTCGGAGGacgccgaggaggaggatggtGATGCTTCCGCAGCAATAGTGGCGGAGGATGAATGCGACGGGGACAATGGAAACAGCGAGGGAAATGGCGCCCCTTTGGACGAGGACTCGCCCTACTTTGAAGACGCACCCAGACGCGGTGGTCGCATCAGCAGCGACGACATTTTCGAGCCCCACATCGACTACCTCTGTCCGCAGTGCGGCAAAGAATTCATCGAGAAGAAGCACTGGCGCACCCACGTGGTCATGGCACACAGCATGAACGACCTGAGCAAGCTTAATTTTGAGATGATAAACGAACGGCAGCTGAAGTGCACTGAGTGCGACAAGATCATAACCAATGCGTATGGAATCCAGAATGCCCAGCAACACAGGATCACGCATCTTCCATTCAAGGCCTACGCCAGGTGTCGCAAGTGCCACAAGTCCTACACAGACAGAAAGGGTCTCGTAAAGCATCTGGCTACCCATCATCGCGTTGGTTGGCCACGAAAGCTATCGGGAGGATGCCCAGCTCCAATTGTTACACCCACCAAGCAGCCACGCAAACAGATAGTAACGATAGCCAATGAAACGTACGAGATAATCTATCTGGACGACGTAGACCAAGGCGGCATGGAGGAGGATAACGACTTTGGTGAACAGATGCAGGCAGAAGAGGATGAATATCCAATTGcatcgccaccaccaccaccaccaccgccacagCCAACATCTCAAGGAAATCATCAACGCTACAAGTGCGTCCACTGTGGCACACTCTTCGCTACCCAGGCGGCCGTCCGTGTTCACATTAGCGAAAAGCGGTGCAGGAAGACAGTGGTCAGAAGGCGTCGACAGCCAGTGATGAACTCTGGGGATCCATCCGTGGCCACCGTAGAACAAAATTACATCTTCTTGTGCCCATCCTGCGGATTTGAGTACAAGACTCAGTTCGAGTGGCGCCGTCACATCAACGAGGTGCACAATTTTGACAAACGTCAATATCTAAACATGCGTCAGTTGGATAAGTATCGCTATCAATGCACCCAGTGCAAGGACATTGTATGCAATTCGAAGCTGAAGGGTTTGCAGGACCATCACTTCCGCCATCTGCCCTACAGACTGTACCTCAAGTGCCTGATCTGCGGCACCTGCTACAATCACAAGCCGAATATAGCTGCACATTTGAGGGCCCGTCACAGCATTTTTGATAGGGAGACGCCGGCGATGATCACAAAACCGAAACAAGTGCTTGGGCGTTATAAGGATAACAGTAGGGAGAACCCCAAATTACCCTCTCCTCCACCGGCTCCCGCACTGGCACCAGCACCGCCCTCACCACCTGCATGCTCCTCCTCTGCTGCTTCCACTGCGAGTAGTCGTTCCCTAAAACCACAGCCTGGCGGATTGCCAGCCCGACCCGCTGGTCTCAACACACTGGAGGACAGCATCTCGTACCACAATGCCGTGGACCTGGACTTCATCACGTACTTTTGTCCCAAGTGCAATCAGAACTTTGACTCTCATGCTTTCTGGCGCAAACATATTGTGGAGCAGCACAACTTTAACAGCCGTGAGGGCCTCAACTTTCGGCAGATCGACAACCATCACTACCTGTGCCTGGAGTGCTACAAACGGGTGACCGTGACGCACACCAAGGGCGCCATCGGGCAGCTACAGTCGCACAAGTTCCGCCACCTGCCCCACAGATCCTTCAAGTGCTTGACTTGCGGCGGTGAGTTTGTGCGCAAGCAAATGTTCTTCAAGCACCTCAACCGCGACACTAACCGGTGTGACAATCGTCCGCACCGAGAATTCGATGACGATGAGCCCGACCAAGATACGCTATTGAGCTCCATTTACCATCTAACGTGCCCGCAATGCGGTGACAACTTCAAAACTCACAATAAAAAGGAATGGCGGGAGCACATCAACGACCACCATGGCTTGACCAAGCTAGAGCTTTTGCACATGACCAAGGTGGGTGAGGATGTCTACCGCTGCCAGGACTGTGATGAGGAGCTGGAGACGAATCGGCAGTGGGTGCTACAGTTCCATCGATTCCAGCACCTGCCCCACGCGGCCTACATCCGTTGCAAACTGTGCAAGCAGAGCAGTGAGGACGATGCTGCTGCGGTGGGTGAGTTGCACAGCCTCCGTGAGCTGCAACAGCACATTCGTAAGCACCATCCAGGCCTGGGGGATGCCGAGATGATATCGCTCATCGAGCAGATAATTCAGGacgagaaggagcaggaggagggcACGAAGCAGACCAATGATGATGAAAACCCTACTGGTCAGGACTCAGGACCGTATATGCCGTTGCCGCCACATCTTCTGGACGATGATGGCGACGTGGAATTCGAAGATCAGTATCTGCTCGGCTAG
Protein Sequence: MEGMDLWTSMFSSDFEEGEAESGAAELEESEQYGNGNDDFLGDTEILDSGDAIDDLLDAEEDEREEEDDYEKNSKEPKQPDPDDDALFDFNMEPIVDIAEPQHPSLAPAGPMGHQVRPPMQRHSFPGAVGRPRLGPGLSVRPTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQRCRECNKRIAMHSRENLLKHKFTHLPFRCTKCYICKREYKYRQDLMVHLRMVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDLGEESDRIEVRNELLEPDVDESGIQEQTVSEEVSKKKAGTRGAAELCEDYIHYMCPDCGTECDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQHHHMDTLISEDAEEEDGDASAAIVAEDECDGDNGNSEGNGAPLDEDSPYFEDAPRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPAPIVTPTKQPRKQIVTIANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIASPPPPPPPPQPTSQGNHQRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMNSGDPSVATVEQNYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPAMITKPKQVLGRYKDNSRENPKLPSPPPAPALAPAPPSPPACSSSAASTASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVDLDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDTNRCDNRPHREFDDDEPDQDTLLSSIYHLTCPQCGDNFKTHNKKEWREHINDHHGLTKLELLHMTKVGEDVYRCQDCDEELETNRQWVLQFHRFQHLPHAAYIRCKLCKQSSEDDAAAVGELHSLRELQQHIRKHHPGLGDAEMISLIEQIIQDEKEQEEGTKQTNDDENPTGQDSGPYMPLPPHLLDDDGDVEFEDQYLLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00539974;
90% Identity: iTF_00539974; iTF_00592022; iTF_00608045; iTF_00619472; iTF_00505009; iTF_00592700;
80% Identity: -