Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:7589180-7597347[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.009 0.56 10.4 0.3 1 23 1269 1292 1269 1292 0.95

2 13 6.4 4e+02 1.4 0.2 1 23 1439 1461 1439 1461 0.91

3 13 0.00014 0.0088 16.1 2.7 2 23 1464 1485 1464 1485 0.97

4 13 5.5e-05 0.0034 17.4 0.2 3 23 1493 1513 1491 1513 0.98

5 13 4.6e-07 2.8e-05 23.9 4.1 2 23 1520 1541 1519 1541 0.97

6 13 4.4 2.7e+02 2.0 0.4 5 23 1554 1572 1552 1572 0.96

7 13 1.1 67 3.9 5.4 3 23 1579 1600 1577 1600 0.93

8 13 0.12 7.1 6.9 0.2 2 23 1611 1631 1610 1631 0.96

9 13 0.00012 0.0072 16.4 0.3 1 19 1637 1655 1637 1659 0.95

10 13 2.8e-05 0.0017 18.3 0.4 1 23 1667 1689 1667 1689 0.98

11 13 8.3e-05 0.0051 16.8 7.6 1 23 1695 1717 1695 1718 0.96

12 13 0.00018 0.011 15.8 6.5 1 23 1723 1745 1723 1745 0.98

13 13 0.0021 0.13 12.4 6.1 1 23 1751 1773 1751 1774 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.009	0.56	10.4	0.3	1	23	1269	1292	1269	1292	0.95
2	13	6.4	4e+02	1.4	0.2	1	23	1439	1461	1439	1461	0.91
3	13	0.00014	0.0088	16.1	2.7	2	23	1464	1485	1464	1485	0.97
4	13	5.5e-05	0.0034	17.4	0.2	3	23	1493	1513	1491	1513	0.98
5	13	4.6e-07	2.8e-05	23.9	4.1	2	23	1520	1541	1519	1541	0.97
6	13	4.4	2.7e+02	2.0	0.4	5	23	1554	1572	1552	1572	0.96
7	13	1.1	67	3.9	5.4	3	23	1579	1600	1577	1600	0.93
8	13	0.12	7.1	6.9	0.2	2	23	1611	1631	1610	1631	0.96
9	13	0.00012	0.0072	16.4	0.3	1	19	1637	1655	1637	1659	0.95
10	13	2.8e-05	0.0017	18.3	0.4	1	23	1667	1689	1667	1689	0.98
11	13	8.3e-05	0.0051	16.8	7.6	1	23	1695	1717	1695	1718	0.96
12	13	0.00018	0.011	15.8	6.5	1	23	1723	1745	1723	1745	0.98
13	13	0.0021	0.13	12.4	6.1	1	23	1751	1773	1751	1774	0.96

Sequence Information

Coding Sequence: ATGGTCGACAACAGTGTCCAATGCCCCGTGTGCACATTGTACCTGCATGCGGGCATGAATCTCTCCGATCACTTGGAGACCCATCCCAAGGAGCAGGTGATCAAGGCACTGGTGCAGATGACGATCGTTGGGAACGGTGGCAACAGCATGGGCAGCGTTCTCGCTGCCGCCATGCTGACAGGAGGAACTGGAGGAGGTGGATCCAGCGGCGGCGAAGCCAGTGCTGATGAGAAACCGGCCGTCATATCACCACCGTCTGGCGGCGATGTCAAACCAGTCGTGGCCAATACCatatcagcagcaacagcgccTGTGCtgccaccagcaccaccaccgctATCCTCCTCCCTCGTGGCGGCCTGCTCCAACGGAGCCGCCTCTTCGACAACCAGCTCCACACCCACCTCCACCTCAgcaagcaacagcagcagcctcagcagcagcaaaccgAGCAATCCACCGATGAAAGCACTGAAATGCTCACCGCCCACAACTGAGGCGCGAGCCAGCACATCCGCACATCCCACCACGAGCAGCGTGTCCACTTTGTACCAGCCAGCGCAGGTCACTCCGGATTACCGCttcaaccagcagcagcagcagccacagacGACGGGCTTTGGGCGTGGTGTCACCACCTCAACAGCCGGTCTGGTGATTCCGCAGGTGCCTCAGCAGCACTTCCTCGCCAGCCATCAACAGCAGGCTCACTTTccacaccagcagcagcccccgcagcaacagcagcagcatccgcagcatCAGCCTGCTCTGAAGTTCAGCTACGCCACAGCTTTGCCCCCACCTCCGCCGTTGCAGCTATttacgcagcagcagcaacagcagacgGTTGTTCCACCGCAGACCCAGCAGCAATCGCACCAGAAACCACCTCCCGCCTATGGAGCCGCCATTAGTCAAATACGATCTCAGcacaaccaaaacaaacagcagccaCAGTCCCAAAGCGTAGCTATGCAACACAGCCTATCCCTGGCACCAACGACGACATCAGCGGCTTCAACTTCACACGCAACTGCAGCGGTCAAGCAGACCAGTAAACCGCAAACGGAAGTATTCCTGAATCCCCCACCACCGCCATCGGCacagcaacagttgcagaTCCACAATTTAGTGCAAACTCAAGGTCAACACCATCAGCAGCCTCACCATCAGCAGTCGCAGCCGAGCCAGCAGAGTCACCAACAGCCACCGAGCTTGCAGACCTACGGATTAGGGGTCAGCAGTAGCTGCAGTTCCTCCAACAACCCCTCGACCTCGGGATCTGGTCATCGTGTGAATCGTCAGACAAACTCACCGTTTGGAGCACTGCTAAATGCTGCAGCGGCTGTGGCCTGCGCATCGCCGGCCTGTCCCACCACCGCATCTTCGGTATTGAGGTTTGCAGAATCACCGGTGGCACACTACCTTGAGCGGGAAAATGGTGACTTCATTGTCCAGGAGACACCGAAGCATATTGTAGAGTGTGTTGAGAAGGAAGACGGCGAGTTTTCCGTGATCGAGCGCATTTATCAATCCCCGCCGAGTGTTCTGCACATacacgatgatgatgaggatgacgaggatgaagaggaggaggacgagcaTGAAGCTCCGCCCGAGGAAGAAGACGGAGACGATGAGCGGGAGGAGAACAGCCACAGCCGTAATATAAGCAAGACAACGAAAAAGGCCCGTAAGACGAAGCCGAAGCGCGGCTCCAAGCGCATGTCGGACGAGGAGGAATTCATGAGCCTGAGCAGCGGATGTGAGAGTGAGTTGGAAAAAGAGCGTAAGCAGGAGCAACTAAATGTAGCGGCATCACTACCACCTCCATTGTGCACGGCTCCTTCTAcgagtgctgctgctggagcttcCACCTCCAATCTGGCGGACAATCATTCCAATTCCGCGTCCAACTCCGCCTCCAATTCGAACTCCACCGCCACTACAAAGTCCAAGAAGAATCGAATTACCGTACTCAGCGATGTTCCGCTCAATATGAATGAGTACCTCGATTTGATGGGCAACATCGTAGCCTCCAGTCGCATTGGGGCAAGTCGACCGTTTGCCGCTGTGGCCCCCATACCACTCGTCAAGGTGGAGAAGGAAGAACCCCTAGATGATTACGACAACGTGGCAATGGCCGCTAATGCCGAGCTGGAGCAAAAGCCCAGCCTTGAGCACGGCACCACCAGCGTCATTCGAATGGCAAGCACGGCTGCAGCGTCGACTTCTGCAACGGCGACCGAAACGTCTCCCGAGGATCTCACCCAGCCGCCGCCCATGAAAGTCGAGGTTGAGGCGACCACCACATTGTTGCCGCAGCGCTTTTCAACTCCCGCCCAGCATCGTGGGCCTAAGAAATTAGTCatcaaaccaaaacaaacagcacCAGCGACAGCGACGACAACAAAAAAGACTGACACCCCATCTTCCCCCAGCAACAACCCATCCATATCAAGAGATCTGGTGCAAGTAAAGAGTGAGACCCTGGAGGCGCCAGCGACgagcagtagcagtagcatTCTGGAGAAGCACCTAACCGCCAGCCGAAAACTATTGCATCATCACTCGGCGGTGAACGATGACGATGCCCGGGTGCTGCTTGAGTTTGCAAACTCCAAGCAGCCGCCGCCACTGGCAGCGTCGAGCACAACGTTTGTGGTTAATGCCAGTGTGGGCTTTCCCTCGGCTGGCTCAGTTTTcgccagcagcagtagcagctgTTCCAAAGCACCGGCCAAGCCGGGAGAGGAGTACATCCTGCCGGACAACAACATGGACGTGGATGAGATTGTGATATCCTCGTCGTCTTCCTACACCTCCACCGCAGCCCAGGTGCAGAACACGTTACAGCCGCCGGACTTTAACTTTCTGTACCACCAGGCCACTACCACGGCTACGACGGCCACATACTTTAATCCCTTCTCcaggcagcagcatcatcagcaccagcagcagcacggcGTCAGCGATGCCACCAATGCGGCCACTTTGGCATCGTCGTCCAGCAATTCGTTGGACCACGACTCGATGAATGCTACATTCCGGGTGGCCAAGACCCAATCGCTGCAGTCATGGTATCAGCAAGAGCCGGATCACGATCCACAGAATCAGGGTGGTGCGGAATCGGGAACTGCCACTCCCTCCAATCAGAGCCAGGATGTGGTCAGCCACCAGCCAACCAACTTTAACGCCGCCCTGGCGGCCGTCGATTGCTGTAGCGTTGCTTTGGACGAGGATGCAAAATATCTTGATCTAGACGCCTGCAAGCGGGAGCAGCtgagcagcagtagcaaccTGCCATCCGCTTCCGCGTCCACAACGTCGTCGTCGTTCGCTGGCGCTGGCACGGAAAGCAGTTTGGTGGGTGGTTTGAATATCCGAACCGATGAGAAGATGCCCGCTAAGGGTGAAATCTCCGAACAGGAAAGCAACTGCGACATCGAGAACTCCTGGAGTGAGTCGGTGTATGGGGATATTTCGCAGCGGTACTTCAGAAACCAGTTTTCCGGCGGCTACAACCCTGATTGGCGACAGGACTATTATCCGGCTCAGGATCTCAGCGCTCAGCAGAGAGAGCAAAAACGTTTTGACTTCAATGCTGTCGATGATGAGGCTTCATCTAGCTCGAGAAGGAGCCATCTTACAGATCTTCTCCCGACAGCGGCCACCTCCTCCGCATGTACGTCATCAGCTATGCTGGCGGGTCCACCAATAGCTTCGACATCACGGGCTGCTGCTGAGGCGGCAGCGGAGGCGGCTGCTCTTGCCCAGCGGAAACCGCAGCGCCGCAAGCTCTACAAGTGTCCACACTGCGAGGCGATCTTCGAAAAGCTTAAGGAGCGTAATGCGCACATGATTGGCGAGCACAACTACGTGCGGCAAAATCGCCGTCTAATTTGCACTCAGCCGCAAATGAATACTTCGATGTTACCGCCACAGCAACAGATGATAATGCAGGCAGGTGAGGTTGAGGATTCCAAGGATGGCATTGTGAAGATAAAACAGGAGCAATGCCAGGAAAAGCATGATGTTGAGCAAATGCACGACCATTCCGAACTTTTGGCCGATGTCAAGGACTCTGAGCTGATGGGCATCGGCGGTGATGGCGACGGTGATGTAGATGACGACATTAAGCCACCCAACCAGCTAGATGAAAAGCCCACGCTGCCGCCATTAGCCATGACGACCCCAGCGGCTAAATTAGCAGCTTTGTATCGAATGCTCATCGCCTACAACGAATCCAAGCTCGGACAGGAGCGCAACAATCTTAGCGAGCTGGAGCAGAAGGCTATGGAAAAATCCATATTTCTCTGCTATGTCTGCCGTACCGACTTCCCGTCCGTAAAGCTCTATGACGCCCATCTCACCGAGCATCCCGCTGAATGCTTTACTTGCGGCAAGAAGTTCTACCGCTGGAAGAACTTCTCCTTGCACTTAAAGCGGCACTTGGGCTGGAAGGAGTTCGGATGCTATGTCTGCGACAAGAAGTTCGTGGTGCGCAGCGCCTTGGTCGAACACATGCGGATGCACACGGGGCAAACGCCACTCAAGTGCAAGATATGCgGTAAAAAGTTCAAGCGATACTCGAATCTGACGCAACACCGCAAACGCCACACCAAAATGATGGTGCGCAAAAAGGAGTACGTGTGTCACTGCGGCGAAGTCTTGCCCTCGAAGGCTCGCTTCCTGTGGCACAAGGAAACGCACGACCTGAAGCCGAAGTGCTGCCCGTACTGCTGCGATCGGTTTGTGCACGCCAACTCGCTACGTCGACACATACGGCTGGCCCACTCTGATAAGTTTGACTATGCCGAACCTATGGAATGCCCTATGTGTAAGCAAATCTTCGCGAAGACGTCCATCAAGGCGCATATGGCGACGCATTCAACGGAGCCCCAATACGATTGCGCCATTTGTAGCAAGAGCTTCTCCACCAAATGGAATCTCAAGATCCACTCGTGGGTACACGCCAACCGGACGGCCAAGCCCTTTAAGTGCGAATACTGCCCAAAGGCGTTCGTGCGAGAGTTGGACTTCAAGAACCACATCAACGCGCACAAACAGATCAAACCGTACACGTGCGAGTACTGCGGCTGCAAGTTCATCCGCAAGTACAATTACATGCGACACCGGCGCGAACATCATGGCACCAAGAAGTTCACCTGCGACCAGTGCGATAAGTCCTTCCATCGGCATTACTATCTGATAGAGCACCGGCGAATGCATACCGGAGAGCGTCCGTTCACGTGCACCATCTGCGGCAAGAGCTCCACAACCAAGACCAACCACAACAAGCATCTGAAGATCCACCATTCGCGCGATCCCTTCACGGTGGAGGTCTAA
Protein Sequence: MVDNSVQCPVCTLYLHAGMNLSDHLETHPKEQVIKALVQMTIVGNGGNSMGSVLAAAMLTGGTGGGGSSGGEASADEKPAVISPPSGGDVKPVVANTISAATAPVLPPAPPPLSSSLVAACSNGAASSTTSSTPTSTSASNSSSLSSSKPSNPPMKALKCSPPTTEARASTSAHPTTSSVSTLYQPAQVTPDYRFNQQQQQPQTTGFGRGVTTSTAGLVIPQVPQQHFLASHQQQAHFPHQQQPPQQQQQHPQHQPALKFSYATALPPPPPLQLFTQQQQQQTVVPPQTQQQSHQKPPPAYGAAISQIRSQHNQNKQQPQSQSVAMQHSLSLAPTTTSAASTSHATAAVKQTSKPQTEVFLNPPPPPSAQQQLQIHNLVQTQGQHHQQPHHQQSQPSQQSHQQPPSLQTYGLGVSSSCSSSNNPSTSGSGHRVNRQTNSPFGALLNAAAAVACASPACPTTASSVLRFAESPVAHYLERENGDFIVQETPKHIVECVEKEDGEFSVIERIYQSPPSVLHIHDDDEDDEDEEEEDEHEAPPEEEDGDDEREENSHSRNISKTTKKARKTKPKRGSKRMSDEEEFMSLSSGCESELEKERKQEQLNVAASLPPPLCTAPSTSAAAGASTSNLADNHSNSASNSASNSNSTATTKSKKNRITVLSDVPLNMNEYLDLMGNIVASSRIGASRPFAAVAPIPLVKVEKEEPLDDYDNVAMAANAELEQKPSLEHGTTSVIRMASTAAASTSATATETSPEDLTQPPPMKVEVEATTTLLPQRFSTPAQHRGPKKLVIKPKQTAPATATTTKKTDTPSSPSNNPSISRDLVQVKSETLEAPATSSSSSILEKHLTASRKLLHHHSAVNDDDARVLLEFANSKQPPPLAASSTTFVVNASVGFPSAGSVFASSSSSCSKAPAKPGEEYILPDNNMDVDEIVISSSSSYTSTAAQVQNTLQPPDFNFLYHQATTTATTATYFNPFSRQQHHQHQQQHGVSDATNAATLASSSSNSLDHDSMNATFRVAKTQSLQSWYQQEPDHDPQNQGGAESGTATPSNQSQDVVSHQPTNFNAALAAVDCCSVALDEDAKYLDLDACKREQLSSSSNLPSASASTTSSSFAGAGTESSLVGGLNIRTDEKMPAKGEISEQESNCDIENSWSESVYGDISQRYFRNQFSGGYNPDWRQDYYPAQDLSAQQREQKRFDFNAVDDEASSSSRRSHLTDLLPTAATSSACTSSAMLAGPPIASTSRAAAEAAAEAAALAQRKPQRRKLYKCPHCEAIFEKLKERNAHMIGEHNYVRQNRRLICTQPQMNTSMLPPQQQMIMQAGEVEDSKDGIVKIKQEQCQEKHDVEQMHDHSELLADVKDSELMGIGGDGDGDVDDDIKPPNQLDEKPTLPPLAMTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAMEKSIFLCYVCRTDFPSVKLYDAHLTEHPAECFTCGKKFYRWKNFSLHLKRHLGWKEFGCYVCDKKFVVRSALVEHMRMHTGQTPLKCKICGKKFKRYSNLTQHRKRHTKMMVRKKEYVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKFDYAEPMECPMCKQIFAKTSIKAHMATHSTEPQYDCAICSKSFSTKWNLKIHSWVHANRTAKPFKCEYCPKAFVRELDFKNHINAHKQIKPYTCEYCGCKFIRKYNYMRHRREHHGTKKFTCDQCDKSFHRHYYLIEHRRMHTGERPFTCTICGKSSTTKTNHNKHLKIHHSRDPFTVEV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00529734;
90% Identity: iTF_00591878;
80% Identity: -