Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:11684537-11698437[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 1.9e-05 0.0012 18.8 2.1 1 23 221 243 221 243 0.97

2 18 6.4e-06 0.0004 20.3 0.4 1 23 249 271 249 271 0.97

3 18 0.00095 0.058 13.5 0.9 1 23 277 299 277 299 0.95

4 18 1.4e-05 0.00084 19.3 3.1 1 23 305 327 305 327 0.97

5 18 3.1e-05 0.0019 18.2 4.7 1 23 333 355 333 355 0.99

6 18 5.6e-05 0.0035 17.4 5.7 1 23 361 383 361 383 0.97

7 18 2.8e-07 1.7e-05 24.6 4.3 1 23 389 411 389 411 0.98

8 18 9.9e-08 6.1e-06 26.0 2.4 1 23 417 439 417 439 0.97

9 18 5.8e-05 0.0036 17.3 6.7 1 23 446 468 446 468 0.97

10 18 0.0001 0.0062 16.6 6.5 1 23 474 496 474 496 0.98

11 18 9e-06 0.00055 19.9 4.5 1 23 502 524 502 524 0.98

12 18 6.5e-06 0.0004 20.3 8.1 1 23 530 552 530 552 0.98

13 18 5.3e-06 0.00033 20.6 7.6 1 23 558 580 558 580 0.97

14 18 5.9e-07 3.6e-05 23.6 7.7 1 23 586 608 586 608 0.98

15 18 0.00019 0.011 15.7 9.5 1 23 614 637 614 637 0.95

16 18 6.6e-05 0.004 17.2 0.9 1 23 643 665 643 665 0.98

17 18 0.00072 0.044 13.9 3.4 1 23 675 697 675 697 0.97

18 18 8.2e-06 0.0005 20.0 1.6 1 23 703 726 703 726 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	1.9e-05	0.0012	18.8	2.1	1	23	221	243	221	243	0.97
2	18	6.4e-06	0.0004	20.3	0.4	1	23	249	271	249	271	0.97
3	18	0.00095	0.058	13.5	0.9	1	23	277	299	277	299	0.95
4	18	1.4e-05	0.00084	19.3	3.1	1	23	305	327	305	327	0.97
5	18	3.1e-05	0.0019	18.2	4.7	1	23	333	355	333	355	0.99
6	18	5.6e-05	0.0035	17.4	5.7	1	23	361	383	361	383	0.97
7	18	2.8e-07	1.7e-05	24.6	4.3	1	23	389	411	389	411	0.98
8	18	9.9e-08	6.1e-06	26.0	2.4	1	23	417	439	417	439	0.97
9	18	5.8e-05	0.0036	17.3	6.7	1	23	446	468	446	468	0.97
10	18	0.0001	0.0062	16.6	6.5	1	23	474	496	474	496	0.98
11	18	9e-06	0.00055	19.9	4.5	1	23	502	524	502	524	0.98
12	18	6.5e-06	0.0004	20.3	8.1	1	23	530	552	530	552	0.98
13	18	5.3e-06	0.00033	20.6	7.6	1	23	558	580	558	580	0.97
14	18	5.9e-07	3.6e-05	23.6	7.7	1	23	586	608	586	608	0.98
15	18	0.00019	0.011	15.7	9.5	1	23	614	637	614	637	0.95
16	18	6.6e-05	0.004	17.2	0.9	1	23	643	665	643	665	0.98
17	18	0.00072	0.044	13.9	3.4	1	23	675	697	675	697	0.97
18	18	8.2e-06	0.0005	20.0	1.6	1	23	703	726	703	726	0.96

Sequence Information

Coding Sequence: ATGCAGCACGTGAGCGCTGCCAGCTCTGTGCCATCAGTAGTAACTCCTGTTGTGACCACTGGTGGGACAACGATTACATTGGGCGGCCCACCACCGCTTCCTAAATCCGAGCACAAAGAGGATGGCAAGCCGCCGCACGGCATCGAAATGTACAAGGTGAACATTGAGGACATTTCGCAGCTCTTCACCTACCACGAGGTCTTTGGCAAAATCCACGGCGATGTGGTCAATCATCAATTAGCAGCAGCCCACGGCGGCCAGttgccaccacctcctccgctaCCGCCGCAGGTTACCAGCCATGCGGCGAGTGCAgcggcagccgcagcagcggcgTCCACGAATAATGCCGCCGTTGCAGCGGTAATGGCATCAGCGAATGCAGCAGCGGCcgcggcggcagctgcatcGGCGGGGGGAGGACTACCGCCGGCCACCAGCGGCAATGGGGGCCAGCAGGTGACGGTGACGACGACCAGCAGCTCGACTAGCAGCGGCGGGAGCACCACCAGTGGGGGCACCACGACCACGGCGGGTGAGTTGCTTATGCCTAAAATGGAGGGCGGCATTCATGGCGTGGACGGCAGCGGCAATGGCGGCAATGGTGGCGGGCAAAACGTGGCGCTGGCGCCAGACGGTACGCCCATTGCGACGGGGACGCACGTCTGCGACATCTGCGGCAAGATGTTCCAGTTCCGGTACCAGCTGATCGTGCACCGGCGCTACCACAGCGAACGGAAGCCGTTCATGTGCCAGGTGTGCGGCCAGGGGTTCACCACGTCGCAGGATTTGACGCGCCACGGCAAGATCCACATTGGCGGGCCCATGTTCACCTGCATCGTGTGCTTCAATGTGTTCGCGAACAATACGAGCCTGGAGCGGCACATGAAACGGCACTCGACGGACAAACCGTTCGCCTGCACCATTTGCCAAAAGACCTTTGCCCGCAAAGAGCATCTGGACAATCACTTCCGCTCGCACACGGGCGAAACGCCCTTCCGTTGCCAGTACTGCGCCAAGACGTTCACGCGCAAGGAGCACATGGTCAACCATGTGCGCAAACACACGGGTGAGACGCCACATCGTTGCGATATTTGTAAGAAGTCCTTTACGCGCAAGGAACACTATGTTAACCACTACATGTGGCACACTGGTCAAACGCCGCACCAGTGCGATGTCTGCGGCAAGAAATACACGCGCAAGGAGCACCTAGCCAACCATATGCGATCACATACCAACGAGACGCCGTTCCGTTGCGAGATCTGCGGCAAGAGCTTTAGCCGCAAGGAGCACTTCACCAATCACATACTTTGGCATACAGCAGGCGAGACGCCGCACCGGTGCGACTTTTGCTCCAAGACGTTTACGCGCAAGGAGCACTTGCTTAACCACGTGCGCCAGCACACGGGAGAGTCGCCACACCGCTGCTCCTACTGCATGAAGACGTTCACGCGCAAGGAGCACCTGGTCAACCACATACGCCAGCACACGGGTGAGACACCGTTCAAGTGCACGTACTGCACGAAAGCGTTCACGCGCAAAGATCACATGGTTAATCATGTACGGCAACATACAGGCGAGTCGCCGCACAAGTGCACGTACTGCACCAAGACGTTTACGCGCAAGGAGCACCTGACGAACCATGTGCGCCAGCACACGGGCGACTCCCCGCACCGCTGCTCCTACTGCAAGAAGACCTTCACGCGCAAGGAGCACCTGACGAACCATGTGCGCCTGCACACGGGCGACTCGCCGCACAAGTGCGAGTACTGCCAGAAGACGTTTACGCGGAAGGAGCACCTCAACAATCATATGCGCCAGCATTCGAGCGACAATCCGCATTGCTGCAACGTTTGCAACAAGCCGTTTACGCGCAAGGAGCACCTGATCAACCATATGTCGCGGTGCCACACCGGTGACCGGCCCTTCACCTGCGAGACGTGCGGCAAATCGTTCCCGCTCAAGGGCAATCTGCTCTTCCATCAGCGTAGCCATACCAAGGGCCAGGAGATGGAGCGGCCATTCGCCTGCGAGAAGTGCCCCAAGAACTTCATCTGCAAAGGTCACTTGGTCTCGCACATGCGCTCCCATTCGGGTGAGAAACCACACGCGTGCACACTGTGCAGCAAGGCGTTCGTCGAGCGCGGCAATTTGAAGCGCCACATGAAGATGAATCACCCGGATGCTATGATGCCGCCACCACCCgtgcatccgcatccgcaaaTACCGGCTGGTGTGCTGACGCAAGTCAAGCAGGAAGTGAAACCGATCATAATTCCCCATCACTCGGCGACCACCACGATGCACACCATCCAGCAGATCACGGCGGGTGCGGCGGGCGGAGCCGGTGCGGTCCAGTTAACTCCGGGTCTGGTGCCCCTGGTTACCTCCACGCTCATCTCACATAATGCTGCTGCCCAACAGCAGTCGCAGAAGCAGcaagcagccgccgcagcagctgcacagCAACAGGCCgcagccgccgctgctgcccaACAGCAAGCAGCCCAGCAACAGGCAGCAGCCgcacatcagcagcatcaacaacaagTGGCCgcgcaacatcaacagcaggcTGCAGTGGCTgctcaccagcagcagcaacagcagttgcagcagcagcaacaactgcttCAGTTGTCCATCCAACAGGCGGCTCACCATcatcagcaggagcagcatcgtcaacagcagcaacagcaacaccagcagcaacaacagcagcagcatcaccagcagcaacagcagggtCATCCACAGGCCCcgccaccgcagcagcaacagcagccgccgccCATCGCCTTGATCAGTGACCCAAGTGCTCTGGCACGCGCCGCCATCCAGCTGCAGCATCTGCCAGCGAACGTGGAACAGCACCCGGTTGTTTACTAA
Protein Sequence: MQHVSAASSVPSVVTPVVTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTAGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00505532;
90% Identity: iTF_00507738;
80% Identity: iTF_00592516;