Basic Information

Insect: Drosophila santomea
Gene Symbol: L
Assembly: GCA_016746245.1
Location: NC:18166368-18170434[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 8.3e-06 0.00053 19.9 0.4 1 23 10 32 10 32 0.99

2 14 0.008 0.51 10.5 0.2 2 23 112 136 111 136 0.92

3 14 0.0026 0.16 12.1 0.2 2 23 159 181 158 181 0.95

4 14 0.041 2.6 8.3 0.7 1 23 265 287 265 287 0.97

5 14 0.0023 0.15 12.2 0.1 2 23 295 316 294 316 0.91

6 14 2.8e-05 0.0018 18.3 0.5 1 23 324 348 324 348 0.95

7 14 3.3 2.1e+02 2.3 0.9 2 23 384 406 383 406 0.94

8 14 0.0017 0.11 12.7 1.1 1 23 451 474 451 474 0.97

9 14 0.0033 0.21 11.7 1.2 2 23 657 679 656 679 0.96

10 14 0.027 1.7 8.9 0.1 1 23 685 707 685 707 0.92

11 14 0.032 2 8.6 0.1 2 23 715 736 714 736 0.96

12 14 0.49 31 4.9 0.5 2 23 834 855 834 855 0.94

13 14 0.0064 0.41 10.8 0.0 1 23 865 887 865 887 0.96

14 14 0.00023 0.014 15.4 1.2 1 23 894 916 894 916 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	8.3e-06	0.00053	19.9	0.4	1	23	10	32	10	32	0.99
2	14	0.008	0.51	10.5	0.2	2	23	112	136	111	136	0.92
3	14	0.0026	0.16	12.1	0.2	2	23	159	181	158	181	0.95
4	14	0.041	2.6	8.3	0.7	1	23	265	287	265	287	0.97
5	14	0.0023	0.15	12.2	0.1	2	23	295	316	294	316	0.91
6	14	2.8e-05	0.0018	18.3	0.5	1	23	324	348	324	348	0.95
7	14	3.3	2.1e+02	2.3	0.9	2	23	384	406	383	406	0.94
8	14	0.0017	0.11	12.7	1.1	1	23	451	474	451	474	0.97
9	14	0.0033	0.21	11.7	1.2	2	23	657	679	656	679	0.96
10	14	0.027	1.7	8.9	0.1	1	23	685	707	685	707	0.92
11	14	0.032	2	8.6	0.1	2	23	715	736	714	736	0.96
12	14	0.49	31	4.9	0.5	2	23	834	855	834	855	0.94
13	14	0.0064	0.41	10.8	0.0	1	23	865	887	865	887	0.96
14	14	0.00023	0.014	15.4	1.2	1	23	894	916	894	916	0.97

Sequence Information

Coding Sequence: ATGAAGACGCATGACATTCAGAAGCCCTTCCAGTGCAGCATGTGCAACAGGGGCTACAACACAGCTGCCGCCCTCACCTCGCACATGCAAAAGCACAAGAAGAACGCCGCCATCCTGGCAGCCGGTGGCAATCCGAATGCCCTCAACTACAGTCCACGGTCCACGGGATCCGCTTCGGCATCGGTGTCCAGCAATGGTAGTCTGCAGAAGCGGCGATATGCCCTGGCTTTGGCATCCGACAGCAGTCCCAGTAGATTGGATTTCCCCAAGCGATCGAGGAGTAATCAAGTGGGCggcaacaccaccaccactgccACACCCACGCCGCTGCTCAGATGCAGCTACTGTCCCAAGGTCACGGAGTTCAGCAGCCTGGAGCAACTGAATGCCCATCTGCAGAGTGTCCACGAGCAGCCACAGGCGCAGGCTGTGAAGACGCCGGTTCAGACGCCGGAGGGCGAAGGCTTCCAGCTGAGCTGTGAGTACTGCACCATGAAGTTTGGCAATATCGCCGGACTCTTTCAGCACATGCGTGGCACTCACATGGACCGATTGAGTAGTCCAAACTCCTACTACGAGCACTTCAATCGCCTGGCCACCGTTGGCACTTTCAGTCCCCGCCTGGCATTGGACTTGCCCAAGATTAAGCCGGACTTGGGAAGTCCGGAGCGGGAATCGCGACCGGCAGAGGATGATCTGCCCACGGACTTGAGCAGCAACAAGCGGCGACCACTGACACCCAATGCCCAAGTGCCGACTCCACTGGCTCCACCCACTGCACCGCCGGGCGTGTTCTTCTGCAATCAGTGCAACGCTGGACTGCCGGATTTCGAGAGCTTTAGGAACCATCTGAAGAGTCACATTGCCGAGGGCATGCAGCTGGTTTGTCCGCACTGCGGCTTGAGTTTGCCGGAGCAATCGGAGTTTGAGCGTCATGTGGTGGGACACTTTCTCATCACGGGCTCGGAGTTCAACTGCAGCTCGAGCTGCGGAAAGAGTTTCGCCAAATCGGAGGATCTGCAGCAACACTTGCTAACGGAGCACGTCCTAACCCTGCTGAAGTGTTCCTTGTGCTCGGAGCTCTGCGAAAGCCGTATGGCCATGCAGCTGCATCTGGCCTGTGCCCACAGTCAGGAGACCAAGCTGCTGCGCTGCAGCGCCTGTCTGGAGCTCTTCCGCTCCGACGCCGAGTTCCATGTGCATGTGAAGACGCGTCATCAGTTGGGCGGCCaccccacgttgggcgccacttCTAATGCGCCCACCAATCCGCTGCAGTGCATGTTCTGCCGTGCAGTTTGCTCGTCCGAGCTGGAAATGCACTTCCATTTGGCCGCACATGCACGTCAGTTCCGGTGTCCTTCCTGCCCGGAGACCTTTCACGTGGAGTTCCTGCTGGATCGTCACATGCAGAGTCAGCATGGCGGTGTCAAGGACAAGGAGGCTAACTCGCCCAACATGGGCAGTCTCTATGTGAATGCCTTGCTGCCTCCTttggcggcagcggcggcggcagcagcggccaccaacaacaacagcagcatcatcgACTACAATGTGGCATTCAAGGGTTTATTCGGAGCAGCTTCCGGGGCAGCAGGAtcaggcggaggaggaggaggagcacaaGCTGGTGGTGCCCCGCCATCGGCGAACAAATTCTACAGCCCTCTGCAGGTGGACACCAATGCACTGAAGGCGCAAACCTCTCCGCATCCGGCTCTAATGTACGGCCTCAGTCAGCGGTATCTGATGGAGATGTATGCCGCCAAGTCCACATCGCCCTCGGGCAACGAGGGAGTGGGTAACTCGCAGCCAGCGGCTCCACAAGCAACCGCACCGCCACCACCAAATGCCAGCACTGCCACCTTCAGTTGCGGAATGTGCGAAAGGCAGGACTTGCGCAGCGAGGCGGAACTGCACTCCCATCGCAAACTGGCCCACAACCTGAAGACGGGCGTCAGTCTGAGGTGTGCCTACTGTGCGGGCAACTTTAAGTCGCGGGCCGAACTGGAGCAGCACATGAAGAGCTGTCACAACTCGACGGGCAAGCACAAGTGCTTGATATGCGACGAGGTGTTTCCCTCGCCAGCCATCCTGGCCGAGCACAAGCTCCAGCACTCGAAGGTGGGTCAGTCCGGCAAGTGTTCGCACTGTGGACAGCCCCTGGAGGATGTGGCCGCCTTTAGGGCGCATCTATCGGAACATGGAAGCGATGGCGCCTCCTTGCCACTAGCCTGCATTTGCTGCCGCCAGACGTTGCACTCGGAATTTGAGCTGAGTCTGCATGCCAAATTCCACACAAAGTCCTCATCGAGCGGCGGCAGTCTGCAGGAGCCAGTGTGTGCTCTGTGCCTGGAACCACTACCAGATGCCACCGAGGGTCCAGCCAAACTGTGTGACAAGTGCTGCCGCAAGCACAACCTAAATGGAAAACGTGGCAAGCACTCCGAGCCCCAGACATCTCTGCCAGCTGCGCCGTCGGCGTTTGTGGAGAACCGCTGCAACCTGTGCAAGATGATCCTGCCGCATGCCCAGAAGCTCCAGGAACACCTGGTGGAGCACACCTTTGCCGGCACCGAGCAGCGCGGCTTCAACTGCTACATCTGCTCGGCCGTTTTCACCGCACCCGGCGGACTACTCAACCACATGGCCGAGCACGGAGCCCATTCGCGACCCTACGACTGCAGCCTCTGCCCGGAGAAGTTCTACTTCCGAGCCGAGCTGGAGCACCACCAAAGGGGTCATGAGCTGCGACCACAGGCACGACCTCCAGCACCGAAAGTGGAGGTGCCAACCATGCGGAACAGCTCACCCGGCCAGAGTCCGGTGAGGAGTCCCACCATTGTCAAACAGGAGCTGTACGAAACGGACACAGTGGAGTCTGCCGGAGTGGATGATGAGCCGGGTAATGCTCCAGATGAGGAGGAGTACATTGAAGTGGAACAAATGCCGCATGAGACACGTCCAAGTGAGATTGGGTCGCAATTGGAAAGGTCCACCAGCAGCGCCTAA
Protein Sequence: MKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRLDFPKRSRSNQVGGNTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQAQAVKTPVQTPEGEGFQLSCEYCTMKFGNIAGLFQHMRGTHMDRLSSPNSYYEHFNRLATVGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLSSNKRRPLTPNAQVPTPLAPPTAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGLSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLTEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSNAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGAASGAAGSGGGGGGAQAGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPAAPQATAPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSLHAKFHTKSSSSGGSLQEPVCALCLEPLPDATEGPAKLCDKCCRKHNLNGKRGKHSEPQTSLPAAPSAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMAEHGAHSRPYDCSLCPEKFYFRAELEHHQRGHELRPQARPPAPKVEVPTMRNSSPGQSPVRSPTIVKQELYETDTVESAGVDDEPGNAPDEEEYIEVEQMPHETRPSEIGSQLERSTSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548267;
90% Identity: iTF_00504840;
80% Identity: -