Druf013634.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rufa
Gene Symbol
ftz-f1
Assembly
GCA_018153105.1
Location
JAECXS010000085.1:11782228-11798283[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-18 1.2e-14 54.4 3.7 1 78 201 277 201 301 0.73
2 2 2e-71 1.5e-67 228.6 2.9 154 408 307 554 255 556 0.81

Sequence Information

Coding Sequence
ATGTTATTAGAAATGGATCAGCAACAGGCGACCTATATATTTCCGACAGGCTATCAGGACACCACCTCCTCGCATTCCCAACAAAGTGCTGGCGGCGGCGGCGGAGGTGGCGGTGGCAACGGCGGCAACCTCCTGAACGGCAGCTCCGGCGGCTCATCCGTCGGCGGTGGCTATATGCTCCTCCCCCAAGCGGCCAGCTCCAGTGGCAACAACGCTGGCGGCGGCGGCGGTCACATGTCCTCCGCTTCCGTGGGCAATGGTGGCGGCAATGGCGGAGGAGGCGGCGGAGCTGGCGGCAACTCTGGCGGTCCGGGCAACTCGATGGGCGGCACAAGTGCCACGCCGGGTCATGGCGGCGAGGTGATCGACTTTAAGCATTTGTTCGAGGAACTGTGCCCCGTGTGCGGCGACAAGGTGAGCGGCTATCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGCACCGTGCAGAACAAGAAGGTCTACACCTGTGTGGCGGAGCGATCCTGCCACATCGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGATTCCAGAAGTGCCTCGAAGTCGGCATGAAATTGGAGGCTGTTCGAGCGGATCGGATGCGGGGTGGACGGAACAAATTCGGACCGATGTACAAACGGGATCGGGCGCGGAAGCTGCAAGTGATGCGGCAGCGGCAGTTGGCGCTGCAGGCGCTCCGCAACTCGATGGGTCCGGACATCAAGCCAACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATTCAAATACCTCAGGTATCCTCACTCACCCAATCGCCGGACTCATCGCCCAGCCCCATTGCCATTGCGCTGGGACAGAACACGGCCGACTCGAAATTGTGCTTCGATTCGGGCACACATCCATCGAGCACAGCCGATGCGCTAATCGAGCCATTAAGAGTCTCACCAATGATTCGTGAATTTGTGCAATCAATCGACGATCGGGAATGGCAGACGCAACTGTTTGCTCTGCTGCAAAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTCGAGCTGATGTGCAAAGTGCTCGACCAGAACTTGTTCTCGCAAGTGGACTGGGCACGGAACACGGTCTTCTTCAAGGACCTCAAGGTCGACGATCAAATGAAGCTGCTGCAGCATTCGTGGTCGGACATGCTGGTCCTTGATCACCTGCACCATCGCATTCACAACGGCCTGCCCGATGAGACGCAACTGAATAATGGTCAGGTCTTCAATCTGCTGAGTCTGGGCTTGTTGGGCGTACCGCAGTTGGGCGATTACTTCAACGAGCTGCAGAATAAGCTGCAAGATCTGAAATTCGATATGGGCGACTATGTCTGCATGAAATTCCTAATCCTCTTGAATCCAAATGTGCGGGGTATTGTCAACCGGAAGACTGTATCCGAGGGACATGATAATGTGCAAGCCGCTTTGCTGGACTACACCCTCACCTGTTATCCGTCAGTTAATGACAAATTCAGTAGGCTAGTGAACATCTTACCGGAAATCCATGCCATGGCCGCACGCGGCGAGGAGCATCTATACTCCAAGCACTGTGCCGGCAGTGCGCCAACCCAAACACTGCTCATGGAGATGCTCCACGCCAAGCGCAAGGTGTAG
Protein Sequence
MLLEMDQQQATYIFPTGYQDTTSSHSQQSAGGGGGGGGGNGGNLLNGSSGGSSVGGGYMLLPQAASSSGNNAGGGGGHMSSASVGNGGGNGGGGGGAGGNSGGPGNSMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPNVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFSRLVNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00524446;
90% Identity
iTF_00600350;
80% Identity
iTF_00590291;