Basic Information

Insect: Drosophila repleta
Gene Symbol: egg_1
Assembly: GCA_018903745.1
Location: JAEIGN010000497.1:4074498-4079101[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2e-14 7.9e-11 41.2 0.0 5 75 914 977 911 979 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2e-14	7.9e-11	41.2	0.0	5	75	914	977	911	979	0.90

Sequence Information

Coding Sequence: ATGGACAGTTCGGAAAACGACGCTGCATCATCAGTTGACTCTCCACTTGAGGCAGGGGCTTTGCCGGCTGGAAATGCAAGCAGAGATACAGAAGAAGAAGAGGAAGAGGGGGAAAAGGCAGAATGTGAAGAGATGTCTTTGGATGAAGATGATCACGATGAGCCGTCGAAGCCTAGTTCTGAAGCTAAAGAATCGGAGAAATCAGATGCCACTGAACCAGACAAGAGCATTCCTGAAATTACATCTGAGGAAAAAACAGAGGAATCATCAATAATTAAAATTGATTCGGCCAAACCAACTGAAACGGATTTGGATAGCAGCATCGAACTAATCAGTAGCCCAACTTCCGAACAGTTGGAAGCCGCAGACAAGAATGACAAGGGCTCAACTGAGGAAAGTGATGCATTAAAGGAATCTGTTGGCCCCGTAGTGGAATCAACGGATGCTGAAAAATCGACCGAAGATGATGTGGATAGCAGTATTGAAGTAATCGAAAGTCCCGCATTAAAAGAATTAAGCGAAACGGATAATAGAAAGGACAGTAAGGCGGACAGCGACAGTAGTATTGAAGTAATTAGCAGTCCGGGTAACACAGAAGAGGACAAGAAAGACAGAAGAGGACAAGACAAGGTAGAAACTGAATCCAAAATGGACGACGAAGAGAACCTCAATAGTATTCCTGAAAAAGAAGATATAGAGAGTGAAGAAAAACAGACTATCAACGATAACATCACAGAATCAAAAGCAAATACTGAGGATGCCATAATAGCAACCGCTGAGCCCAATTCAGCTTTGCCAGCAAAAAGCACAGTTGCAGAAGAGGAACCAGCTTCACCCCAATCACTGACAGTGGATGAAGAAGTGCAGCATCCCAATGATTTAGGCAATGCACAGAAAGAATCAAACAAAGATGAACCCATGGAAACAGAGTCTTGTCCAGAAGAAGTTAAAAACAGCTGTGTAGTAAAGCTACAAGAAGAAGATCACACAGAAACGAAGCCCGAAAGTGACTCAAAAGAGTCCGTTGACCATGAGGACGATAACGAAATCTACTACAAGAAGGATTGTATCAACTGCAATTGCGAAAAGCTACACAAGCAATATGTGCGCGCAAGCTTGGCAGCTCTCAACTATTACAAGGTGCCCAGGAAGGCCCACAAGCGACAGTACATATGTATGGGGTGCAATGACACAGCCATTGACATGTATGAGGATTATGCGGGTCACTTAGTGGCCAAGCAGCCGCTGCTGCTGCGCAGCTTCAACCAGAATCATGCGGACTTTGTAGCCCTAGACAGTAGTGATGAGGAGGAAGACGATGATCAGCAGAGCAAACCCGAGTTCTCAGCAAAGGATTTGAAGTTAATTGAAAACGAATTGGAGGATGCAATAAAAACTGTAATAAACAGAGTGGATTTAAATGACCAAATGGCTTGGTCAAAGAGCATACTTCAGGCAAAAGCAGATCGCATTGGCCAAGAAATTGATATGGCCAATGAAGAGCTCTCCAAGTTGCAAAATATGGCAGACAAAATGCACTTTGCCTTGTACAGTTCCTGCCAAGTGGTGCACAAGCACTTGCCGCCACTTGATCTGTACCACAACATGAACGATTACGTGCAAGTGCCTCCAGCTGGCGAGATAGAGCGTCCACCCATTCAGCTAAACGAAACCTACTATGCGGTAAAGAACAAAGCAATTGCCAGTTGGGTCTCAGTCAAAGTGATTGAGTTCACGGAGAGCACTACGGTGGGCGGCAACCTGACTAAGAGCTACAAGATTAAATATCTCAATACACCATATCAAATGGTGAAAACCGTAACGGCCAAACACCTGGCCTACTTTGAACCACCGCCAGTACGCTTAACTATAGGCACTCGCGTGATAGCCTACTTCAATGGCAGCACTTTGTCGCGTGGCAAAGAAAAAGGTGTAGTGCCCAGCGCATTTTATCCGGGCATCATAGCGGAGCCCCTAAAGCAAGCCAATCGTTTTAGATATCTAATATTTTATGATGACGGCTATACACAATATGTGCAGCATAGCGATGTGCGTTTGGTTTGCCTGGCGTCGGAGAAAGTGTGGGAGGATGTGCATCCCGGCTCCCGAGATTTTATACAAAAGTATGTGGAGAAATATTCTGTGGATCGACCTATGGTGCAGTGCACCCGTGGCCAGAATATGAATACGGAATCCAATGGCACCTGGCTGTATGCGCGCGTAATTGACATTGACTGCAGCCTGGTGCAGATGCAGTTCGACGATGACAAGAATCACACAGAGTGGATCTATCGGGGTTCTCTGCGTCTGGGTCCGGTCTTCAAGGAGACACAAAACGCATTAAACAGCGCTAATGCCATGCAGCAGCATCGAGTCCCACGCCGCACTGAGCCCTTCATACGGTACACCAAGGAAATGGAGACCAGCAGCAGACAGGTTAACCAACAAATGCGCGCTATTGCCCGGAAGAGCAGCTCCGTGCCACAGAACGTAAATATATNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCACCATCTATGTGGACGACGAGAATCGGCCCAAGGGCCATGTCGTCTACTTCACTGCCAAGCGCAATCTGCCACCTAAGATGTATATGCCACATGAGTGCTCGCCGGCCTGCCTGTTCAAGATAATTCATCGCCTGGATAGCTACAGCCCATTGGCCAAGCCACTGCTCTCGGGTTGGGAGCGTTTGGTATTTAAGCAGAAGGCCAAGCGAAATGTTGTCTATCGTGGCCCTTGTGGCAAGAGTTTCCGCAATCTGGCCGAGGTGCACACCTATCTGCGTGCCACCGACAATGTGCTAAACGTGGAAAACTTTGATTTTACGCCTGATCTACGTTGCCTGGCGGAATACTCCATAGATCCCACTATTGTTAAGGAAGCGGACATATCGAAGGGTCAAGAAAAAATGGCCATACCACTCGTTAACTATTACGACAACACATTGCCACCCCCATGTACTTATGCCAAACAGCGCATACCAACAGAGGGAGTGCATCTTAATCTCGACGAGGAGTTCCTGGTGGGCTGTGATTGTGAGGACGATTGCTCAGACAAATCAAAATGTGCCTGCTGGCAGCTGACGGTTGCGGGCGTCCGCTACTGTAATCCCAACAAGCCAATCGAGGAGATTGGCTACCAATACAAACGACTGCACGAGCATGTGCCCACCGGAATTTATGAATGTAACTCACGTTGTAAATGCAAAAAGAACTGTTTAAACCGTGTGGTCCAGCATTCGCTGGAAATGAAGCTGCAGGTGTTCAAGACCTCGAATCGGGGCTGGGGCTTACGGTGCGTCAACGATATACCGAAAGGTGCTTTCATATGCATATATGCCGGTCACTTGCTAACTGAAACAATGGCCAACGAGGGTGGCTTGGATGCGGGAGATGAGTACTTTGCCGATTTGGACTACATTGAGGTGGCCGAGCAGTTGAAAGAGGGCTACGAGTCGGATGTTGAGCACTCGCCAGCGGAAGAGGAAGAAGACACGTATGCTCCAGATCCGGAGGATGATGCTGATTTCATGCCTGCTAAGCATTATCTACCGCGCAAAAAGGACAAACTACGAGCAGCCCGCAGCCAGCCCACACCATCCACGGAGCAGGACTCGCAGGAGAGAGCAGTGATTAACTTCAATCCGAATGCAGATCTGGATGAAACAGTGCGCGAGAACTCAGTGCGTCGACTCTTTGGCACAGACGAAGCGCCCTACATAATGGATGCCAAAACAACTGGCAATTTGGGTCGCTACTTTAATCATTCGTGTGCACCCAATTTGTTTGTGCAGAACGTGTTTGTGGACACGCACGATCTGCGTTTTCCCTGGGTTGCTTTCTTCTCGGCCAACCACATACGCTCCGGCACCGAACTCACTTGGAACTATAACTATGAGGTGGGCGTGGTGCCTGGCAAAGTTCTCTATTGTCAATGCGGAGCAACTAATTGTCGAATACGTTTGCTTTAA
Protein Sequence: MDSSENDAASSVDSPLEAGALPAGNASRDTEEEEEEGEKAECEEMSLDEDDHDEPSKPSSEAKESEKSDATEPDKSIPEITSEEKTEESSIIKIDSAKPTETDLDSSIELISSPTSEQLEAADKNDKGSTEESDALKESVGPVVESTDAEKSTEDDVDSSIEVIESPALKELSETDNRKDSKADSDSSIEVISSPGNTEEDKKDRRGQDKVETESKMDDEENLNSIPEKEDIESEEKQTINDNITESKANTEDAIIATAEPNSALPAKSTVAEEEPASPQSLTVDEEVQHPNDLGNAQKESNKDEPMETESCPEEVKNSCVVKLQEEDHTETKPESDSKESVDHEDDNEIYYKKDCINCNCEKLHKQYVRASLAALNYYKVPRKAHKRQYICMGCNDTAIDMYEDYAGHLVAKQPLLLRSFNQNHADFVALDSSDEEEDDDQQSKPEFSAKDLKLIENELEDAIKTVINRVDLNDQMAWSKSILQAKADRIGQEIDMANEELSKLQNMADKMHFALYSSCQVVHKHLPPLDLYHNMNDYVQVPPAGEIERPPIQLNETYYAVKNKAIASWVSVKVIEFTESTTVGGNLTKSYKIKYLNTPYQMVKTVTAKHLAYFEPPPVRLTIGTRVIAYFNGSTLSRGKEKGVVPSAFYPGIIAEPLKQANRFRYLIFYDDGYTQYVQHSDVRLVCLASEKVWEDVHPGSRDFIQKYVEKYSVDRPMVQCTRGQNMNTESNGTWLYARVIDIDCSLVQMQFDDDKNHTEWIYRGSLRLGPVFKETQNALNSANAMQQHRVPRRTEPFIRYTKEMETSSRQVNQQMRAIARKSSSVPQNVNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTIYVDDENRPKGHVVYFTAKRNLPPKMYMPHECSPACLFKIIHRLDSYSPLAKPLLSGWERLVFKQKAKRNVVYRGPCGKSFRNLAEVHTYLRATDNVLNVENFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLVGCDCEDDCSDKSKCACWQLTVAGVRYCNPNKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGLDAGDEYFADLDYIEVAEQLKEGYESDVEHSPAEEEEDTYAPDPEDDADFMPAKHYLPRKKDKLRAARSQPTPSTEQDSQERAVINFNPNADLDETVRENSVRRLFGTDEAPYIMDAKTTGNLGRYFNHSCAPNLFVQNVFVDTHDLRFPWVAFFSANHIRSGTELTWNYNYEVGVVPGKVLYCQCGATNCRIRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00516256;
90% Identity: iTF_00568246;
80% Identity: -