Basic Information

Gene Symbol
L
Assembly
GCA_037043535.1
Location
JBAMBI010000160.1:6567319-6575543[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 1.1e-05 0.00073 19.9 2.9 1 23 178 200 178 200 0.98
2 16 0.37 25 5.6 6.2 1 23 206 228 206 228 0.97
3 16 0.014 0.95 10.1 3.2 1 23 234 257 234 257 0.92
4 16 1.3e-05 0.00089 19.6 0.4 1 23 263 285 263 285 0.99
5 16 0.024 1.7 9.3 0.2 2 23 358 382 357 382 0.90
6 16 0.0012 0.08 13.5 0.2 2 23 415 437 414 437 0.95
7 16 0.029 2 9.1 0.7 1 23 519 541 519 541 0.97
8 16 0.0049 0.34 11.5 0.1 2 23 549 570 548 570 0.91
9 16 0.00075 0.052 14.0 0.4 1 23 578 603 578 603 0.94
10 16 4.5 3.1e+02 2.2 1.5 2 23 639 661 638 661 0.94
11 16 0.0047 0.32 11.5 1.1 1 23 712 735 712 735 0.97
12 16 0.0017 0.12 12.9 1.8 2 23 906 928 905 928 0.96
13 16 0.12 8.2 7.1 0.1 1 23 934 956 934 956 0.92
14 16 1.1 79 4.0 1.8 2 23 964 985 963 985 0.95
15 16 0.77 53 4.6 0.5 2 23 1084 1105 1084 1105 0.94
16 16 0.00032 0.022 15.2 0.9 1 23 1142 1164 1142 1164 0.97

Sequence Information

Coding Sequence
ATGATGGCTTTAAAGATGCTATATCGCGGTCCCAGTTCGCGTTTGgagaatttaattgaaaagattCAAGCTACAAAGGAGATTTCGAGCAACgATATGTACAGCACGCACACCTCCTCCAGTTACTCGCCAAGCATCTCGGATGGCACAATGACGCCCAACTCGCAACATCCGCATCCAGTTTCTGGCGAGGATCCTAACTCCGATAGGGTCAAATCAAATGGGGATACGACAACTCCAGCTGAAGAGGAGAGGGAAcaggagagggagaaggaaagagagagagaaccaCCCAAGCTAAAGAGACCCGCACatttgcatcatcatcatcatcattatcatcatcagcaagcgctgaaaattgccaacaaattgCGGAAAATCAATAAGGAAGCAAAGCTCACAGGACCCACAGGAGGTGGAAACGGAAACGGTGGAGGtggcggaggaggaggcggaggTGTACACGGTGTAGCCACAAAGTTTGATAAGTTGACAGGCGAGGGCATTAAGAGTCGAGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGTTACTTGAAGCATCACGTCCAGAGCCATGCCGAACATTTGCCTTTCAAATGCGAATACTGCGCCAAGTTATTCAAGCACAAGCGCTCCCGAGATCGTCATAAGAAGCTCCATACCAACGAGAGGAACTACAAGTGTCCGCATTGTGAGGCCGCTTTCTCAGAAGGTAATGACCATCTGAAGATCCACATGAAGACGCATGACATTCAGAAGCCCTTCCAGTGTAGTATGTGTAATCGGGGCTATAACACGGCTGCCGCCTTGACCTCGCACATGCAGAAGCATAAGAAGAATGCGGCAATACTGGCAGCTGGCGGCAACCCTAATGCCCTCAACTATAGTCCACGCAGCACAGGCTCAGCCTCCATCTCGAGTAATGGGAGTCTTCACAAGCGACGCTATGCCTTGGCTCTTGCCTCCGACAGCAGTCCAAGTCGTATGGAGTATCCGAAACGTGGGCGTGGTCATGTGGTAACAACGCCTACTCCAACACCGTTGCTTCGTTGCAGTTACTGTCCCAAGGTGACGGAGTTCAGCAGTCTGGAGCAATTGAATGCGCATTTGCAACAGGCACATGAACAGCAGACAAGGAtctccacaacaacaacaacaacgacaacatcagGACCAGCTGGAGGAGATCAGGAGTTGCAATCGAATGGTTTTCAACTGAGTTGCGAATATTGCACCATGAGGTTTGTGAATATTGCTGGATTGTTTCAACATATGCGTGCCACACACTTGGATCGTTTAAGCAGTCCCAACTCCTACTATGAGCACTTCAATCGTCTGGCCACAGCCGGAACTTTCAGTCCAAGATTAGCCCTAGAACAGCCCAAGATCAAGCAGGATTTGAGCAGTCCACAGCAGGAGAAACCGGAACAGGATTTACCCACAGATTTGAGCAGCAATAAAAGACGCACATTGACACCCCCTTCAGCACTAGCACCCCAACAGGCACCAGCACAAGCGCCACCTGGCGTCTTCTTTTGCAATCAATGCAATGCGGGACTTCCGGACTTTGAAAGCTTTCGTAATCATCTGAAAACCCACATAGCCGAGGGCATGCAACTAATCTGTCCCCATTGTGGATTAAGTCTTCCCGAAAAGAGTGAATTTGAACGTCATGTGGTTGCCCATTTTTTGATAACCAGCTCCGAGTTTAATTGTACTGCTGGGAGTTGCAACAAATCCTTTGGCAAGTCGGAGGATTTGCAACAGCATTTGAATAGCGAGCATGTGATTACCGTGCTAAAATGTGGACTCTGCTCGGATCTGTGTGAGAACAGGATGGCCATGCAGCTTCATTTGGCCTGTGCCCATAGTCAGGAAACGAAGCTACTGCGTTGCAGCGCCTGCATGGAGATCTTTCGCAATGATACTGATTTCCATGTGCATGTCAAGACCCGACATCAAGGAGGAGCTCCAGCTGGTAACGTTCCTCCTGCTCCAGCTGCTGGTCCTGCTGGTGGACCAGCTAATCCTTTGCAGTGCATGTTTTGTCGTGCCGTCTGCTCCTCGGAATTGGAAATGCATTTCCATTTGGCGGCACATGCTCGACAATTTCGTTGCCCCTCCTGCCCCGAAACATTCCATGTGGAATTTCTGCTGGACCGACACATGCAAAATCAACATGGCGGAGTCAAGGAGTCACCCACAAAGGAGCAAAGTTCACCCAACATGGGCAGTCTCTATGTGAATGCATTGTTGCCACCACttgcggcagctgcagcagctgctgcagcggcaaccaataacaacagtagTCTGCACATTGATTACAATGTGGCATTCAAGGGACTCTTTGGAGGAGCAAGTAATGCTGCCACACCCGCTGGTGGTGGCAAGTTCTACAGTCCGTTGCAAGTGGACACAAGTGGATTGAAGCCACAACAATCACCACATCCGGCTCTTATGTACGGACTCAGTCAACGCTATCTGATGGAAATGTATGCGGCTAAAGCGACTTCTCCGGCAGCGGCAAGTGCTCCGGATGTGCCTGTCCAGCAGTCGTCCGGTGCCACAGCTTCTAGTGCAACCAACAGCTACAGTTGTGGCATGTGTGAGCGTCAGGACTTGAGGAGTGAGGCGGAACTTCATTCACATCGTAAGTTGGCCCACAATCTAAAAACCGGAGTCAGTTTGAGATGCGCCTATTGCTCGGGAAACTTTAAATCCCGAGCAGAGCTGGAGCAGCACATGAAGAGTTGTCACAACTCGAGTGGCAAGCACAAGTGTCTCATTTGCGATGAGATCTTTCCGTCTCCGGCCATTCTGGCCGAGCACAAGCTGCAGCACTCCAAGGTGGGACAATCCGGGAAGTGTGCCCATTGTGGACACCAGTTGGAGCACGTAGCCGCCTTCCGAGCTCATCTAACTGAGCACGGAAGTGATGGTAATCTTCCGATGGCCTGCATCTGTTGCCGTCAGACTCTACACTCGGAGTTCGAGCTGAGTCTTCATGCCAAGTTCCACACCAAGTCCCCGAGTGGTGGAGGAAGTCTCCAGGAACCGGTTTGTGCTCTGTGCTTGGAACCATTGCCTGAAGCCGGAGAAACTGCCAAATTGTGTGAGAAATGCTGTCGTAAGCATAATCTCAATGGAAAGCGGAACAAGGAGGCAGCTCCTATTGTAGGAGCAACTGCTCCACAAAATGCCGCCTCCACCTACTTGGAGAACCGTTGTAATCTCTGCAAAATGATCTTGCCACATGCTCAGAAACTTCAGGAGCATCTTGTGGAACACACCTTTGCCGGCACCGAGCAGCGTggatttaattgttatatCTGCTCTCGCCGTATTCACCGCGCCCGCCGGACTGCTGACCCACGTGCCGAGCACGGTGCTCGTCCCTATGACTGTAATCTGTGTCCTGAGAACTTCTACTTTCGTGCCGAACTGGAGCATCATCAACGTGCCCATGAACTGAGACCGGCACCTCCTTCAGCTGGAAGGATTCCTCCTAAGCAGGAGACTCGCAGCTCATCGGCCAGTTCACCCATGGCTCTGAGTCCTAGCCATGTTAAGCAGGAGCTCTATGAATCCGAGACGGCGGCCTCTCCCGCCGCAGATCCATCAGCCCCGGAGGATGAAGAATACATTGAAGTGGAGCAAGTGCCGCATGAAATCCGTTCCGGAGATCTTCTCACTTCCGCTCACACCGAACGTTCCAGTAGCAGCGCCTAA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATKEISSNDMYSTHTSSSYSPSISDGTMTPNSQHPHPVSGEDPNSDRVKSNGDTTTPAEEEREQEREKEREREPPKLKRPAHLHHHHHHYHHQQALKIANKLRKINKEAKLTGPTGGGNGNGGGGGGGGGGVHGVATKFDKLTGEGIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSEGNDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRMEYPKRGRGHVVTTPTPTPLLRCSYCPKVTEFSSLEQLNAHLQQAHEQQTRISTTTTTTTTSGPAGGDQELQSNGFQLSCEYCTMRFVNIAGLFQHMRATHLDRLSSPNSYYEHFNRLATAGTFSPRLALEQPKIKQDLSSPQQEKPEQDLPTDLSSNKRRTLTPPSALAPQQAPAQAPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEKSEFERHVVAHFLITSSEFNCTAGSCNKSFGKSEDLQQHLNSEHVITVLKCGLCSDLCENRMAMQLHLACAHSQETKLLRCSACMEIFRNDTDFHVHVKTRHQGGAPAGNVPPAPAAGPAGGPANPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQNQHGGVKESPTKEQSSPNMGSLYVNALLPPLAAAAAAAAAATNNNSSLHIDYNVAFKGLFGGASNAATPAGGGKFYSPLQVDTSGLKPQQSPHPALMYGLSQRYLMEMYAAKATSPAAASAPDVPVQQSSGATASSATNSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNFKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGHQLEHVAAFRAHLTEHGSDGNLPMACICCRQTLHSEFELSLHAKFHTKSPSGGGSLQEPVCALCLEPLPEAGETAKLCEKCCRKHNLNGKRNKEAAPIVGATAPQNAASTYLENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSRRIHRARRTADPRAEHGARPYDCNLCPENFYFRAELEHHQRAHELRPAPPSAGRIPPKQETRSSSASSPMALSPSHVKQELYESETAASPAADPSAPEDEEYIEVEQVPHEIRSGDLLTSAHTERSSSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00507081;
90% Identity
iTF_00608662; iTF_00558149;
80% Identity
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