Basic Information

Gene Symbol
-
Assembly
GCA_018153035.1
Location
JAECXR010000024.1:6394223-6397289[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 1.7e-06 0.00012 22.1 5.5 1 23 206 229 206 229 0.97
2 17 6.1e-05 0.0043 17.2 0.1 1 23 236 258 236 258 0.97
3 17 0.19 13 6.3 0.1 2 23 290 311 289 311 0.94
4 17 0.00015 0.011 16.0 1.4 1 23 400 423 400 423 0.97
5 17 0.22 15 6.1 0.6 1 19 430 448 430 451 0.93
6 17 0.022 1.5 9.2 5.3 1 23 460 482 460 482 0.95
7 17 6.1e-06 0.00043 20.4 0.4 1 23 489 512 489 512 0.97
8 17 0.00035 0.025 14.9 2.4 2 23 520 541 519 541 0.96
9 17 0.016 1.1 9.6 0.1 2 21 568 587 567 588 0.94
10 17 0.0061 0.43 10.9 2.5 1 23 637 660 637 660 0.98
11 17 0.018 1.3 9.4 1.3 1 23 697 720 697 720 0.95
12 17 0.00011 0.008 16.4 1.6 2 23 753 775 752 775 0.95
13 17 0.0026 0.18 12.1 0.1 1 23 789 811 789 811 0.95
14 17 1.6e-05 0.0011 19.1 1.0 1 23 817 839 817 839 0.99
15 17 2.9e-07 2.1e-05 24.5 2.6 1 23 845 867 845 867 0.98
16 17 3.2e-05 0.0023 18.1 3.8 1 23 873 895 873 895 0.97
17 17 2.3e-05 0.0016 18.6 0.5 1 22 901 922 901 925 0.90

Sequence Information

Coding Sequence
ATGAAGCTGCCGGTAAACTGTCGCACCTGCGACTCTTCAGACACCGACAATCTTCTGGAACTGACCACGCCCTCGAAAAAATATCCGGACAAGCTGATCTCCGATATCTTAGCCGAGCTCACAGACATCAATGTGGATGCCACTGCTGGACAGAAAGTGCCACAAGCCCTGTGCCTCGCTTGCACCAAGAAACTAATGGGGGCTTATTGCTATGTGAAGCAGGCGCTGGTCGCCCACGAATTACTGATGAAGCACCTCAAAAGGGTGGCTCCCGCTGTCAGCGCTACCGACTGCTTGGTGGAAGCTCCAATGGAGATATGTGCCGAGCAGCACGTAAAGGTTAAGATGGAGACAGAGGATGAGGAGGATGTTAGCGCCAACAATGTGAGAATAGCTTGCTCGGAGTTAACCGAACCGGATGAACAGGATGTCGACAACAAGAAATCTGTTGATCCGCTGACCATGATAGAGTCGGTTAAGTTAGAGACAGATCCATCTAGCGGGGACTACGTAGTGGAAGGAGCATTCATAACGGATGTTGAGGATGAAGATTCCCTGGACAATTTGCCTCTATTCAAGCGAATTGAAAAGTGGAAAGAAGGCAGAAATAACTTGTTTAAGTGCCACGATTGCCCCCGGAGTTTCAAGCAATCAGAGTACCTAAAGAGACATCAGACCCGTTTCCACAAGCCCGAGACGCTGTGGTTCGCATGCTCCCTCTGCGTTCGCAAGTTCAGTAGCAGCGAAGCTTTAGAAGCACATCTGAAAGTTCACAGAAACTCTAAACGATCTTCCAACGTAAGCGAGCACAAGAAGGCTAAGACTGTGGATCTGAATCTCTGCAAGCCACATGGCTACAAACTAATCGAGTGTATGATTTGTCAGAGCCAGTACAATAAGATTGCGGATCTGCGACGACATTTGGAGGAGCACCCTGATATTGTCACTCTGAGCATGCGTCCAAATATGGAGGCTAATGAACTGGCAGAACTGTTTTATCCAGACTCCAAGCACCTGGACGAGGATCGTTTGATTAATTTAATTCAAAAGGACCTTGCTGCAGGCATTTACCAGCGCTTCTATTCTATTACCAATCAAAGTGGGTATGAAATGGATCTGGACAGCTCCGAGACTGAAAGCGATTTGGATGGAGATCCAGAAGATTCGCATAGACGCAAGAAATACCGCAAGCCCAGCTACATCTGTGAACTTTGTCAACAGAAATTTCCCCGAAAGTATCTTCTGTACGACCACCAACGACAGACTCATAGTTGGTCAGAAGCGCCTCATGTCTGCGGGCGGTGCGATGGCCGCTTCGTGAGTCTCCAGCTGCTGAGGCATCATAACGAATCGCAGTGCAGAAATGCTCAGAAGAGGTTCTTGTGCCACAAGTGTCCGCTGCGCTTCCGTTGGAAACATAATCTGAAGGCACATTTCCGAGAGCACAGGATTACGAATCAAACGTTCGAGTGCCCCGAATGCAAGAGGGTCTTTGACAAGAAGAAGTCCCTCACTGTTCACCTGCTTAGTGTTCATGCCGAGGAGTCGAAGCTGATACCCTGTCAGTGGTGTAGTCGAAAATTCTACCGTCACGATTATTTGGTGAAGCATCTAAAGAGGCACGGCCTCAAGGAGCAGGACATTCCACTAGCCGAGACTCTGATTGCCGCCACATCGCGTCCGAACGGAGCGAAGCGAATCACTTGCCGGATGTGTAACCTGCATTTTGAGCGCATCGTGGATCTTCGGGCTCATATCCAACTAGAACTAAAGCTATCTCTGTCTCTGCACCAAAGTTACGACTCCCCGCACAATTATTCCATAACCAATGAATCTGGTTTCGAGCTGCAACTAGAGGATTCGGAAACGGACGATGAAATACCAACAGGGTCTAGCAATCGTCCCGTTTACGTGTGCGAGCTGTGTAGCGTTCAGTGCAAGCGGAGGTTTGAAATGATCCAGCACCAGAGAACGATGCATAGATTTGATAAAATGCCACACGAGTGCGACGGATGCATCTTTAAATGTGTGTCCAAGAGCATCATGGATCACCATCGTCTGGACCAATGCAATAGTTCGGAGAAGAAGCACATATGCAGCAAGTGCTCCTACAAATTTATGTGGCCGGAGAATCTCGAGCAACATTTGCGCCTGCAGCACAGTAACACAACTAACAGCGATTCCCCCGGTGTCAAGCCGCATAGTGCCCCCGGAGATCTAGACAAGGAAGCGTCAGAGGACGGTGTGCCGCTGTTGCAGTGCCCACATTGCGACCGAACCTACCAGATGAAGTCGCGACTCAACAACCATATCCGTGATGTCCATGTGAACGGTGATCGTAAACGAAAGGAGGCAGTTAAGCGCTTCCTCTGCTCGCTGTGTGGCATGGAAACCCAATCCGCTGCAGCACTGGTGACCCACATGCGCCGCCACACCGGCGAAAAGCCCTTTAAATGCGATCTGTGTGAGATGGCTTTCCCCCGTCATTCCGAGCTAGCATCACATCGTCGGATGCACACCGGAGAAAAGCCATTCCATTGCACAGTTTGCGGCAAGGACTTTGCCCGCTCCGATAAGCTGAAGCGACACATGCTCACTCACAGCGGCCTCAAACCGCACAAGTGCACGTACTGCGAGAAGAGCTATCGACAGGCCAAGGACCTTAAGCTGCACTTGCAGCAGCACACAGGCGAATGCCCTTTCGTGTGTGGGACCTGTGGCGAGCGCTTCATACAGAGCAGCACATTGGAGAAACATCGCCTGATGCGAAGACACTTTGACGAGGGGGAAGCGTGGATTAGGAGTCAGAAGTAA
Protein Sequence
MKLPVNCRTCDSSDTDNLLELTTPSKKYPDKLISDILAELTDINVDATAGQKVPQALCLACTKKLMGAYCYVKQALVAHELLMKHLKRVAPAVSATDCLVEAPMEICAEQHVKVKMETEDEEDVSANNVRIACSELTEPDEQDVDNKKSVDPLTMIESVKLETDPSSGDYVVEGAFITDVEDEDSLDNLPLFKRIEKWKEGRNNLFKCHDCPRSFKQSEYLKRHQTRFHKPETLWFACSLCVRKFSSSEALEAHLKVHRNSKRSSNVSEHKKAKTVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVTLSMRPNMEANELAELFYPDSKHLDEDRLINLIQKDLAAGIYQRFYSITNQSGYEMDLDSSETESDLDGDPEDSHRRKKYRKPSYICELCQQKFPRKYLLYDHQRQTHSWSEAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKAHFREHRITNQTFECPECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEQDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETDDEIPTGSSNRPVYVCELCSVQCKRRFEMIQHQRTMHRFDKMPHECDGCIFKCVSKSIMDHHRLDQCNSSEKKHICSKCSYKFMWPENLEQHLRLQHSNTTNSDSPGVKPHSAPGDLDKEASEDGVPLLQCPHCDRTYQMKSRLNNHIRDVHVNGDRKRKEAVKRFLCSLCGMETQSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDEGEAWIRSQK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00581676;
90% Identity
iTF_00481666;
80% Identity
-