Basic Information

Gene Symbol
MBD2
Assembly
GCA_018150935.1
Location
JAECWR010000094.1:28984249-28985877[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.6e-23 9.6e-20 70.0 0.0 1 74 7 75 7 78 0.94
2 2 0.00037 1.4 8.7 0.0 31 76 112 166 104 167 0.88

Sequence Information

Coding Sequence
ATGAATCCGAGTATTACAATTGAACGTAAACGCGTTGATTGCAACGCACTACCAAAAGGTTGGCAACGCGAAGAAGTACATAAAAAATCGGGCTGCAACTCGGGAGTTGATGTTTTCTACTACAGCCCCACAGGCAAAAGAATTGAAAGCAAACCACAATTAGCACGTCAATTGGGCGCCGAGATGTTTGACATAAGCAACTTTGATTTTCAAACCGGCAAAATGCAACTGCATCGACAAATGCCCTCGCCATCCATATCGCTCTATCGATGCAATGCACAGGGCGCAATTATTAGCAATGCTGTCGCAGGTGGTAATGCTGCGAATGCTCTCAAACATGTCTCCTTGGTGCCACCAATACGGCAGACCGCCTCCATATTCAAGCAACCGGTGACAGTGGTGCGTAATCATGAACCTAACAAGGTCAAGCACGATGCCAAACACGGAGGCCAGGAGAAGCCCAAACAGTTATTCTGGGAAAAGCGCTTGGAGCGTTTACGTGCCTGCCATGACAACGGTGAGGAACTGGACGACATATCACTGCCAAAAACCATTAGAACTGTCGGTCCCAATGTCAACGAACAAACTGTACTGCAATCGGTAGCTACGGCACTGCACATGCTTAATGCTGGCGTTCACGGCCAGAGTTCCACAAAGGCTGAACTAACTAAGAATGCAATGGCATTCATGAATCCAGAACAGCCGCTTATGCATGCGGTCATTATATCTGAGGACGACATACGCAAACAAGAAGACCGTGTTGGATTAGCACGGCGTAAACTTCAAGATGCTCTTAAGACATGA
Protein Sequence
MNPSITIERKRVDCNALPKGWQREEVHKKSGCNSGVDVFYYSPTGKRIESKPQLARQLGAEMFDISNFDFQTGKMQLHRQMPSPSISLYRCNAQGAIISNAVAGGNAANALKHVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGLARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00478717;
80% Identity
-