Basic Information

Insect: Drosophila paramelanica
Gene Symbol: gsb
Assembly: GCA_035043915.1
Location: JAWNMO010000674.1:7395324-7397794[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.2e-71 5.3e-68 226.6 1.1 1 125 19 143 19 143 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.2e-71	5.3e-68	226.6	1.1	1	125	19	143	19	143	0.99

Sequence Information

Coding Sequence: ATGGCTGTATCCGCACTCAATATGACACCCTATTATGCTGGATATCCCTTTCAAGGACAAGGACGCGTCAATCAGCTTGGCGGCGTCTTCATCAACGGTCGCCCGTTGCCCAATCACATCCGTCGCCAAATCGTGGAAATGGCCGCCGCCGGTGTTCGTCCTTGCGTCATCTCGCGTCAGTTGCGCGTCTCGCACGGCTGTGTCTCCAAGATACTGAATCGCTTCCAGGAGACGGGCTCCATTCGGCCAGGCGTAATTGGGGGCAGCAAGCCGCGCGTCGCCACGCCCGACATTGAGGCCAGGATCGAGGAGCTGAAGCAGTCGCAGCCGGGCATCTTCAGCTGGGAGATACGCGCCAAGCTTATCGAGGCGGGCGTCTGCGACAAGCAGAACGCGCCCTCTGTCAGCTCCATATCGCGTCTGCTGCGCACCACCTCGGGCTGCGGTTCGGGCAACGGCACCGGCTCCCACAGCATCGATGGCATCCTGGGCGGCAGCGGCTCCTGCTCGGCGGGCAGCGAGGACGAGAGCGAGGACGACACCGAGCCCAGCGTGCAGCTGAAGCGCAAGCAGCGCCGCTCGCGCACCACCTTCTCGAACGACCAGATTGACGCCCTGGAGCGCATCTTTGCGCGCACCCAGTACCCGGACGTGTACACCCGGGAGGAGCTGGCCCAGAGCACCGGCCTGACCGAGGCGCGCGTCCAAGTCTGGTTCTCCAATCGCCGTGCGCGCTTGCGCAAACAGCTCAACACACAGCAGGTGCCCAGTTTCGGCAGCAGCTCCTCTGCCACCGCCTCGTACGGATCGAGTGCCGTCGCTGCCGCCTCCAACATGGGCATGGGTCTCTACGGCACACAGGCGTGGCCAGCCACTGCCGGTGCCAGCACCTCTGCCTACGAGACACACGCCGGCTACGGCGGCTCCGTGGCATCCATGTCgcccgccagcagcagcagcggcagcacctCCGCCGCCCACAGCCCCGTGCAGTcccagacacagacacagacacagacccTGACGCAGGCGCAGACGCAGACCCAGAGCCAGGcagtggccagcagcagcttcatgAACTCCGCCTATGGCATGGGCAGCGGCTACTCCACCTCGACGGGCGCCTACTCGATGCCGACGTCCGCCGCCAGCTCTGCCGAGCAGCTTCGCTCACAGTTCgcctccgccgccgcctcGGGCTCGCACCATCCCTCGTCCTGGGATGGCTACAACTTTGCCGGCTCCTTCTTCCCCAGCGCCAGTGGCAATCACATGGGCGGCTATCATCAGACGGTCGCCGCCGAGCCCAAGAGCTCCATGATGCCAGCTGCTCCGACCTATCCCTATTTCGGCTTCTAG
Protein Sequence: MAVSALNMTPYYAGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIEARIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRTTSGCGSGNGTGSHSIDGILGGSGSCSAGSEDESEDDTEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFGSSSSATASYGSSAVAAASNMGMGLYGTQAWPATAGASTSAYETHAGYGGSVASMSPASSSSGSTSAAHSPVQSQTQTQTQTLTQAQTQTQSQAVASSSFMNSAYGMGSGYSTSTGAYSMPTSAASSAEQLRSQFASAAASGSHHPSSWDGYNFAGSFFPSASGNHMGGYHQTVAAEPKSSMMPAAPTYPYFGF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00510486;
90% Identity: iTF_00567375; iTF_00541707; iTF_00541610; iTF_00598098; iTF_00597991; iTF_00588692; iTF_00588786; iTF_00560982; iTF_00560875; iTF_00495803; iTF_00495703; iTF_00547196; iTF_00547303;
80% Identity: iTF_00567375;