Dfun003171.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Drosophila funebris
Gene Symbol
gsb_2
Assembly
GCA_018901825.1
Location
JAEIFK010000682.1:3447179-3449594[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.3e-71 5.5e-68 226.5 1.1 1 125 19 143 19 143 0.99

Sequence Information

Coding Sequence
ATGGCTGTATCAGCACTCAATATGACACCCTATTTTGCTGGATATCCCTTCCAAGGACAAGGACGCGTCAATCAACTTGGCGGCGTCTTCATTAACGGTCGTCCTCTGCCCAATCACATTCGTCGCCAAATTGTTGAAATGGCCGCAGCCGGAGTGCGTCCTTGTGTCATCTCCAGGCAATTGCGCGTCTCGCATGGTTGCGTCTCCAAGATACTGAATCGTTTCCAGGAGACAGGCTCCATTCGCCCAGGTGTAATTGGTGGCAGCAAGCCGCGGGTTGCCACACCCGACATTGAGGCCAGGATCGAGGAGTTGAAACAGTCACAGCCGGGCATCTTTAGTTGGGAAATCCGTGCCAAGCTCATTGAAGCCGGCATCTGTGATAAGCAGAATGCTCCTTCAGTCAGCTCCATTTCGCGTCTGTTGCGTGCCACATCTGGCTCTGGTTCGGGCCATGGCACTGGTTCCCACAGCATCGATGGAATTTTGGGCGGAGGTGCTATCTCTGGTGGCAGCGAGGATGAGAGCGAGGATGACACAGAGCCCAGTGTGCAGTTGAAGCGCAAGCAGCGTCGCTCTCGCACCACCTTCTCCAATGATCAGATTGATGCTCTGGAACGTATCTTCGCACGTACTCAGTATCCGGATGTCTACACCAGGGAGGAGTTGGCCCAGAGCACCGGCCTGACTGAGGCGCGCGTTCAAGTATGGTTCTCCAATCGTCGTGCCCGCCTGCGCAAGCAGCTCAATACCCAACAAGTGCCCAGCTTTGGAAGCAACTCCACGGCCACATCATATGGCGCAAGTGCCGCCGCAGCATCCAACATGGGCATGGGACTCTACAGCTCTCAGTCGTGGCCAACTGCCAGTGGTGCTGGCTATGAAACACATCCCGGTTATGGTGGCTCTGTGGCCTCCATGTCGCCTGCCAGCAGCAGCGGCAGCAGCTCTGCTGCCCACAGTCCCGTGCAGTCCCAGACCCAGGCAATTGCCGGTGGCAACTTTATGAACTCCACCTATGGCATGGGCTCAACCAGCATGAGTTATCCTGCCTCTGCTGGCACCTCAACCGCTGCCTACTCCATGCCAACAACCGCCGCCAGCTCTGCCGAGCAGCTTCGCTCACAGTTCGCCTCCGCTGCCGCCTCGGGATCGCATCATCCTTCGTCCTGGGACAGCTACAACTTTGCTGGCTCCTTCTTCCCCAGCGCCAGTGGCAACCACATGGGTGGTTACCATCAATCCGTTGCCGCCGAACAAAAGAACTCCGTGGTGCCAGCTGCTCCCGCTTATCCATACTTTGGATTCTAG
Protein Sequence
MAVSALNMTPYFAGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIEARIEELKQSQPGIFSWEIRAKLIEAGICDKQNAPSVSSISRLLRATSGSGSGHGTGSHSIDGILGGGAISGGSEDESEDDTEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFGSNSTATSYGASAAAASNMGMGLYSSQSWPTASGAGYETHPGYGGSVASMSPASSSGSSSAAHSPVQSQTQAIAGGNFMNSTYGMGSTSMSYPASAGTSTAAYSMPTTAASSAEQLRSQFASAAASGSHHPSSWDSYNFAGSFFPSASGNHMGGYHQSVAAEQKNSVVPAAPAYPYFGF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00510376; iTF_01556673; iTF_01548803; iTF_01550118; iTF_01552294; iTF_01557510; iTF_01553802; iTF_01556780; iTF_01558126; iTF_01551567; iTF_01559599; iTF_01550226; iTF_01550835; iTF_01552403; iTF_01553913; iTF_01548699; iTF_01557403; iTF_01551676; iTF_01558238; iTF_01559710; iTF_01550944; iTF_00606150; iTF_00590185; iTF_00482826; iTF_00590091; iTF_00606251; iTF_00482924; iTF_00480110; iTF_00531600; iTF_00480018; iTF_00531520; iTF_01555359; iTF_00525728; iTF_00525828; iTF_00608387; iTF_00583625; iTF_00557746; iTF_00608278; iTF_00583514; iTF_00557855; iTF_00805128; iTF_00805026; iTF_01570184; iTF_01570084; iTF_00472201; iTF_00553684; iTF_00472310; iTF_00553590; iTF_00492906; iTF_00492801; iTF_00478667; iTF_00568814; iTF_00470706; iTF_00568923; iTF_00470814; iTF_00478560; iTF_00528747; iTF_00528648; iTF_01356077; iTF_01355971; iTF_00508271; iTF_00508161; iTF_00901327; iTF_00901447; iTF_00587344; iTF_00587242; iTF_00537457; iTF_00537346; iTF_00802673; iTF_00802790; iTF_01549521; iTF_01549412; iTF_00562419; iTF_00562308; iTF_00518996; iTF_00519107; iTF_00520468; iTF_00520578; iTF_00533748; iTF_00533641; iTF_00584373; iTF_00584266; iTF_00560982; iTF_00560875; iTF_00610486; iTF_00610596; iTF_00614134; iTF_00614028; iTF_00506808; iTF_00506696; iTF_00509048; iTF_00508941; iTF_00575416; iTF_00575528; iTF_00803544; iTF_00803441; iTF_01558872; iTF_01558982; iTF_00522905; iTF_00522794; iTF_00805913; iTF_00805809; iTF_00585914; iTF_00585804; iTF_00567483; iTF_00567375; iTF_01553019; iTF_01553130; iTF_01555963; iTF_01556071; iTF_00579229; iTF_00579124; iTF_00556478; iTF_00556395; iTF_00601726; iTF_00601615; iTF_00538175; iTF_00538069; iTF_00585023; iTF_00585136; iTF_01554527; iTF_01554646; iTF_00547303; iTF_00541610; iTF_00541707; iTF_00547196; iTF_00832000; iTF_00832102;
90% Identity
iTF_00522905;
80% Identity
iTF_00510376;