Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 3.9e-06 0.025 14.2 0.1 7 48 71 112 65 116 0.89

2 7 0.0067 43 3.9 1.1 21 45 116 140 109 151 0.76

3 7 0.0043 27 4.5 0.8 17 45 140 168 136 173 0.85

4 7 0.0042 27 4.5 0.8 17 45 168 196 164 199 0.86

5 7 0.00088 5.6 6.7 0.6 17 44 196 223 191 227 0.89

6 7 0.00069 4.4 7.0 0.1 21 44 228 251 224 255 0.89

7 7 0.0039 25 4.6 0.2 21 44 256 279 252 286 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	3.9e-06	0.025	14.2	0.1	7	48	71	112	65	116	0.89
2	7	0.0067	43	3.9	1.1	21	45	116	140	109	151	0.76
3	7	0.0043	27	4.5	0.8	17	45	140	168	136	173	0.85
4	7	0.0042	27	4.5	0.8	17	45	168	196	164	199	0.86
5	7	0.00088	5.6	6.7	0.6	17	44	196	223	191	227	0.89
6	7	0.00069	4.4	7.0	0.1	21	44	228	251	224	255	0.89
7	7	0.0039	25	4.6	0.2	21	44	256	279	252	286	0.85

Coding Sequence: ATGGCACAAACGATAGACGTGGGCTGCGTCAAGGAGGAGCACTGTGAGGCGATTTGCAATATGTTTAAAGCCCAGGATTGGCCACTGACCATGCGACACAGGGACCTGGGTCTGGTTAAGATCGAGCAGGACATGAGCTTTGTGTGGCAAAGCAGCCCCAGTGTCACCCTGGACGGCAAGGACCGACAACCAGAGAAGCAGGGCCAAAAAAAATTCCAGCACGGTGGCAAAACGCCGTACAGCGGGTCGGCCAGCGAGAAGCCTTTCAAGTGCGCACACTGCCCCAAGGATTTTGCCACCAGCAGCAATCTGAAGGTGCATCTGACGCGCACCCACTCCGGAGATCGCGAGCGCCCGTTTTTGTGCCCCAACTGCCCCAAGTCGTTTGCGACCAATGATAATCTGCAGAAGCACATACGCAGGCATTCGAGCGAGCGCAACTTCAACTGTCCACACTGCCCCAAGGCCTTTGCCACAAAGGATAATCTACAGAAGCACATACGCCGGCACTCGAGCGAACGCAACCTCATCTGTCCGCATTGTCCCAAGGCATTTGCCACCAACGACAATCTGCAGAAGCATATACGCCGGCACTCGAGCGAGCGCACCTTAAATTGTCCACACTGCCCGAAGGCATTTGCCACCAATGATAATCTGCAGCGGCATATACGCGGTCATACGGGTGAGCGACCCTTTAAGTGTCCCTATTGCCCGAAACCCTTTGCCCAAAACAGAGATCTCAAAGCGCACATCCTAGAGCATACGGGCGAGAAGCCCTTCAAGTGTCCACACTGCCCCAAGGCGTGCGTTCGCAGCGAGGGCCTCAAGAAACACATACTGCGCCTGCACAAGGACATCGAACCCGAGCAACGACTGACGGCGACCAAGCAATGGCCAACGGGCGACCCAAACGGCAGAGTCTTTATGTACAAATACGATCTAACCAAACACACACGAATGCCCACCGGCGAGGCGTAA
Protein Sequence: MAQTIDVGCVKEEHCEAICNMFKAQDWPLTMRHRDLGLVKIEQDMSFVWQSSPSVTLDGKDRQPEKQGQKKFQHGGKTPYSGSASEKPFKCAHCPKDFATSSNLKVHLTRTHSGDRERPFLCPNCPKSFATNDNLQKHIRRHSSERNFNCPHCPKAFATKDNLQKHIRRHSSERNLICPHCPKAFATNDNLQKHIRRHSSERTLNCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHILRLHKDIEPEQRLTATKQWPTGDPNGRVFMYKYDLTKHTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2