Dnig023056.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila nigromelanica
Gene Symbol
slp1
Assembly
GCA_004149445.1
Location
SCDR01000056.1:69905-70939[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.3e-40 2.3e-37 127.5 0.1 1 87 123 208 123 209 0.97

Sequence Information

Coding Sequence
ATGGTGAAAAGTGTCTGCGAAATGGAATTCAAAAGCAATTTCTCCATCGATGCCATATTGGCAAAGAAACCAACCGCTCCCGCGATCAAGCACGAGCCCATGCCCCACCATCCACATCCGTATCATCCATATGCCAACTCCGATGGCGAACTATCTGCATCTGAAGACTTCGACAGTCCCTCCCGCACCAGCACGCCCATGAGCAGTGCCGCTGAATCGTTGTCGTCGCAGCACAACGATAAGCTCGACGTGGAGGAGTTCGATGATGAGGACATCGAACTGGATGAGGAGGACAGCGATGCCAGCGAGCTGGCCACACAGCCCAGCAAGAAGCAGAAGACAAacgccggcagcagcgacagcaacaagaagCCGCCCTACAGCTACAATGCGCTCATCATGATGGCCATCCAGGACAGTCCCGAGCAGCGACTGACCCTCAACGGCATCTATCAGTATCTGATCAATCGCTTCCCCTACTTCAAGGCGAACAAGCGCGGCTGGCAGAACTCCATCCGGCACAATCTGAGCCTGAACAAGTGCTTTACGAAAATACCGCGCAGCTACGATGATCCCGGCAAGGGCAACTACTGGATTCTGGACCCCTCCGCCGAGGAGGTCTTCATTGGCGAGACCACCGGCAAGCTGCGCCGCAAGAATCCCGGCGCCAGTCGCACCCGCCTCGCCGCCTACCGCCAGGCCATCTTCTCGCCCATGCTCGCCGGCGGCTATGGTGCTCCCGCTGGTTACGGCTATCCCGGCATGCCCTtcgctggcgccgctgctgccgccgccgctgctgctttgtATCAGCGCATGAATCCGGCTGCGTATCaggccgccgctgctgctgctgctgccgccgctgccgctggctaTGGACAGCATCAGCTGCAGTATCAaccggcagctgcagcaccgccgccgccgccgcccagcgcCGCCCATCCGCAGCTGCAGGGCTATCCGGGCGCGCACATGAACGCCGAACTCTTCCAGCGCATGCAGTTCTTTGGCAAGTTTCCGGCCAGCTAA
Protein Sequence
MVKSVCEMEFKSNFSIDAILAKKPTAPAIKHEPMPHHPHPYHPYANSDGELSASEDFDSPSRTSTPMSSAAESLSSQHNDKLDVEEFDDEDIELDEEDSDASELATQPSKKQKTNAGSSDSNKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMLAGGYGAPAGYGYPGMPFAGAAAAAAAAALYQRMNPAAYQAAAAAAAAAAAAGYGQHQLQYQPAAAAPPPPPPSAAHPQLQGYPGAHMNAELFQRMQFFGKFPAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00541577; iTF_00567341; iTF_00547164; iTF_00608244; iTF_00557708; iTF_01355937; iTF_01570049; iTF_00805770; iTF_00518960; iTF_00562276; iTF_00472170; iTF_00553561; iTF_00533605; iTF_00601569; iTF_00584983; iTF_00597957; iTF_01549381; iTF_00616710; iTF_00587207; iTF_00530762; iTF_00589355; iTF_01553772; iTF_01552258; iTF_01555243; iTF_01559565; iTF_01550082; iTF_01548662; iTF_01558085; iTF_01551527; iTF_01556634; iTF_01550797; iTF_00595053; iTF_00803405; iTF_00804989; iTF_01322445; iTF_00475023; iTF_00562987; iTF_00610449; iTF_00506664; iTF_00585765; iTF_00522760; iTF_00584234; iTF_00538035; iTF_00575380; iTF_00583480; iTF_01555928; iTF_01326969; iTF_00528602; iTF_01320273; iTF_00495666; iTF_00520435; iTF_00508906; iTF_00613994; iTF_00579092; iTF_01558836; iTF_00582069; iTF_00545025; iTF_00472867; iTF_00493450; iTF_00540170; iTF_00476427; iTF_00549355; iTF_00509621; iTF_00516060; iTF_00551389; iTF_00573119; iTF_00559296; iTF_01323915; iTF_01321723; iTF_00512525; iTF_00532174; iTF_01327695; iTF_01324705; iTF_01320995; iTF_01326199; iTF_01325466; iTF_01323185; iTF_00544274; iTF_00586483; iTF_00568058; iTF_00572404; iTF_00502325; iTF_00519720; iTF_00554199; iTF_00599386; iTF_00546459; iTF_00479293; iTF_00550744; iTF_00530075; iTF_00505916; iTF_00526383; iTF_00534388; iTF_00490589; iTF_00619646; iTF_00524931; iTF_00513985; iTF_00485666; iTF_00499394; iTF_00548610; iTF_00566594; iTF_00592898; iTF_00494915; iTF_00521155; iTF_00497189; iTF_00497957; iTF_00616005; iTF_00542246; iTF_00576870; iTF_00501609; iTF_00518249; iTF_00527850; iTF_00552842; iTF_00564459; iTF_00595755; iTF_00597165; iTF_00560046; iTF_00582766; iTF_00496399; iTF_00513265; iTF_00482036; iTF_00521973; iTF_00609685; iTF_00576150; iTF_00606872; iTF_00570204; iTF_00573852; iTF_00598687; iTF_00558464; iTF_00492767; iTF_00516799; iTF_00535118; iTF_00511080; iTF_00552113; iTF_00498675; iTF_00543548; iTF_00500112; iTF_00804191; iTF_00508128; iTF_00802639; iTF_00831953;
90% Identity
iTF_00532174;
80% Identity
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