Dleo004108.1
Basic Information
- Insect
- Drosophila leonis
- Gene Symbol
- slp1
- Assembly
- GCA_035045365.1
- Location
- JAWNPC010000202.1:4561260-4562291[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.6e-40 1.8e-37 127.5 0.1 1 87 124 209 124 210 0.97
Sequence Information
- Coding Sequence
- atggTGAAAAGTGTCTGCGAAATGGAATTCAAAAGCAATTTCTCCATCGATGCCATCTTGGCTAAGAAGCCCACAGCACCAGTGATCAAGCATGAGCCCATGCCACATCATCAGCAACCCTATCATCCATATGCCAACTCCGATGGCGAGCTGTCTGCATCCGAAGACTTCGATAGCCCCTCACGCACCAGCACGCCCATGAGCAGCGCTGCCGAATCGCTGTCATCGCAGCACAATGATAAACTGGACGTGGAGGAGTTCGATGATGAGGACATTGAGCTGGATGGCGAGGAAAGTGATGGCAGCAGCGAGCTGGCTGGCAATCCCAGCAAGAAGCAAAAGATCAGCGCTGGCAGTGGCAATGACAACAAGAAGCCGCCCTACAGCTACAATGCGCTCATCATGATGGCCATCCAGGACAGTCCCGAGCAGCGTCTGACCCTCAATGGCATCTATCAGTATCTGATCAATCGCTTCCCCTACTTCAAGGCCAACAAGCGCGGCTGGCAGAACTCCATACGCCACAATTTGAGCTTGAACAAATGCTTTACGAAGATCCCGCGCAGCTACGATGATCCCGGCAAGGGCAACTACTGGATTCTGGATCCCTCAGCCGAGGAGGTGTTCATTGGTGAGACCACGGGCAAGCTGCGCCGCAAGAATCCGGGCGCCAGTCGCACCCGCCTCGCCGCCTACCGCCAGGCCATCTTCTCGCCCATGCTGGCCGGCGGCTATGGTGCGCCCGCTGGCTATGGCTATCCGGGCATGCCCTTTGCgggcgccgctgctgctgccgccgctgccgctttGTATCAGCGCATGAATCCGGCTGCCTATcaggcggcggctgctgctgctgccatggcTGGCTATGGCCAGCCACAGATGCAGTATCAACCGGCCGCTGCACCACCGCCACAGCACAGTGCATCCGCTGCTGCCCATCCACAGCTGCAGGGCTATCCGGGCGCACACATGAATGCTGAACTCTTTCAACGCATGCAGTTCTTTGGCAAGTTTCCGGCCAGCTAA
- Protein Sequence
- MVKSVCEMEFKSNFSIDAILAKKPTAPVIKHEPMPHHQQPYHPYANSDGELSASEDFDSPSRTSTPMSSAAESLSSQHNDKLDVEEFDDEDIELDGEESDGSSELAGNPSKKQKISAGSGNDNKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMLAGGYGAPAGYGYPGMPFAGAAAAAAAAALYQRMNPAAYQAAAAAAAMAGYGQPQMQYQPAAAPPPQHSASAAAHPQLQGYPGAHMNAELFQRMQFFGKFPAS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00560844;
- 90% Identity
- iTF_00472867; iTF_00493450; iTF_00540170; iTF_00549355; iTF_00479293; iTF_00551389; iTF_00805770; iTF_01570049; iTF_00567341; iTF_00597957; iTF_00803405; iTF_00804989; iTF_00518960; iTF_00585765; iTF_00557708; iTF_00608244; iTF_00583480; iTF_00495666; iTF_00572404; iTF_00579092; iTF_00568058; iTF_00545025; iTF_00519720; iTF_00476427; iTF_00512525; iTF_00544274; iTF_00502325; iTF_00509621; iTF_00516060; iTF_00573119; iTF_00559296; iTF_00586483; iTF_00554199; iTF_00599386; iTF_00546459; iTF_00582069; iTF_00547164; iTF_00560844; iTF_00522760; iTF_00492767;
- 80% Identity
- -