Dnig008359.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila nigritarsus
Gene Symbol
Znf574
Assembly
GCA_035044305.1
Location
JAWNMF010000256.1:9453592-9455888[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.8 2.1e+02 2.8 2.6 2 23 341 363 340 363 0.94
2 10 0.21 16 6.4 0.1 6 23 373 390 373 390 0.97
3 10 1.1e-05 0.00083 19.8 5.1 1 23 396 418 396 418 0.99
4 10 0.0097 0.72 10.6 1.2 1 23 424 447 424 447 0.87
5 10 0.00066 0.049 14.3 2.8 1 23 455 478 455 478 0.97
6 10 0.17 12 6.7 0.4 3 23 486 507 484 507 0.92
7 10 1.3 96 3.9 0.3 2 23 519 541 518 541 0.89
8 10 0.0029 0.22 12.2 4.1 1 23 548 571 548 571 0.93
9 10 3.7e-06 0.00027 21.4 3.7 1 23 577 599 577 599 0.98
10 10 0.042 3.2 8.6 3.3 1 23 605 628 605 628 0.97

Sequence Information

Coding Sequence
ATGGATGTACCAGTGGCTGAGGAATGCGTGCTATGCCTGGAGGAGAATACCCTCAGCCTGAACGATTATTTGGACATCTACTCGATGGAGGGCACACAACTGAATGTGGCGAACATAATCAACAAGCATTTTTCATTGCAGCTGGACGAAAGCAGGGGGGGAGCGCGAAAGATATGTTCACACTGCTGGGGCACTGTGTCCGCATTCAATGCGTTGCACGAGTTCGTCAGCGCCGCACAGAGTTCGCTGCAGGACGCGAAGGTGCTGCCCATGGAGGATGATCCCTTGACGCAGAACAACTTCAGCGAGGCACCTAAACAGATTCAGGAGCAAGTCGAACAGAACGGTCGCAATTTCTTCTACCCCGAGGTTAAGATTGAGGAGCATGAGCTGGAACAGCTGCCAAAAATTGAGGTGCTCGAAAGCACGACCAGACTGCAAACGGTGGATCTTGATGCGTCTCCGGTGAGACGATTGCGCAAGCGTGTCAaggctgaagctgaagcaCCAAATGTGGAGGCGTGTGAAGACAGCAATCATGCGGCCAGCAATCATGCGGCCAGCAATCATGCGGCCATAACCGCAGAGGCGCCGAAAAAGCGTCGCGGACGACCGCGCAAAATAGACTTAATAATCAAGGACGCGCCAAGTGTCACGCAAGCTGAACCGACTGTTGACCTAGATGCAGATCTAAAAGCAGAGCCACCTGCCGATTTTAGCGACGATGATCATGATCAGGATTTCGGGAGCCAACCCGATGATGGTGTTGCGCGCAGCGAGGATAGCAGCGTCGAGGAGAGCTCAGAGAGCGATGATGATTCCGACTTTACGGCGGACAAGCCCAGCGAGAGCGACTTCGCAGTCATACCGAAGCGGACGGCAGTGCGGCCCAAGAAATACAAGAAGCGTACGAAGCCAGCGGAGCCGAAAGTCCGCAATACTCgtgagcagcaggagcagcgcaagaagcagcaggaggagTTCGATGGAATCATTGCCAAGTTCTTTAACGATGTGTTGCCGTGCTCCATTTGCAATCTGTTGGTCCACAATTTTACGGAAATGCAACGACATCATCGCCTCACACACCAGGTAGATCCGGGCTATGTGATTTGCTGCGGCCGGAAGTTCACGCAGCGCAAGGTGCTGGCGGGGCACGTGCTGGTGCACTGGAATCCGGATCACTTCAAGTGCACAACCTGCGAGAAATCATTCCAAAACTCACGACACCTGGAGTCGCATCAACAGACACACATGGCCAAGCTATCCTTCGAGTGCGAAACATGTTCCAAGGTCTTCACCAGCAAAACGGCCATCGATTACCATAAACTGAACAAACATGTGCCCATATCCGAATTCAAATTCACGTGCACCGAGTGCAGCAAAAAATTCCTGACCGAACGCAAGCTGAAGAATCACATGAACTCAATGCACGATCCGGAGCGGATAATCATATGCGACAAGTGTGGCAAGCAGATGCGCaccaaaatcattttgaaaaagcATCAGGAGCTCATGCACTCGGATACGCCGCGACCGGAGCCCGAGCTGAAACAGTGCCAGACCTGCGGCGCCTGGCTGAAGGGGATGACCGGTCTGAAGCAGCACATGAAGAGCATTCACGAGGAAAGCGCCGGCGAGCATCGATGTCACGTCTGCAGCAAGGTTTCGCCAAATGCCCGCGCCCTGCGTCGCCATATTTATCACAATCACGAGTGCGAGCGCAAGTTCAAGTGTACCATGTGCCACAAGGCCTTTAAGCGACCCCAAGAACTAAAGGAGCACACATCCACGCACACCGGCGAGGTACTATATACGTGTCCAAACTGTCCGATGACCTTCTTCTGCAGCGCCAACATGTACAAGCATCGCCAGCGTTTGCATCGGGCACAGTACGAGGCGGACAAGAATCAGCCAAAGCCACCCAATATTCTGCAGCAGGCGGTGGGCGCCACAGCCGCCATGAAGATGCAACGCATCCAGCACACGAGTGTGGCCAGCATAGAATCGGACTTGAAGCATTTTTAG
Protein Sequence
MDVPVAEECVLCLEENTLSLNDYLDIYSMEGTQLNVANIINKHFSLQLDESRGGARKICSHCWGTVSAFNALHEFVSAAQSSLQDAKVLPMEDDPLTQNNFSEAPKQIQEQVEQNGRNFFYPEVKIEEHELEQLPKIEVLESTTRLQTVDLDASPVRRLRKRVKAEAEAPNVEACEDSNHAASNHAASNHAAITAEAPKKRRGRPRKIDLIIKDAPSVTQAEPTVDLDADLKAEPPADFSDDDHDQDFGSQPDDGVARSEDSSVEESSESDDDSDFTADKPSESDFAVIPKRTAVRPKKYKKRTKPAEPKVRNTREQQEQRKKQQEEFDGIIAKFFNDVLPCSICNLLVHNFTEMQRHHRLTHQVDPGYVICCGRKFTQRKVLAGHVLVHWNPDHFKCTTCEKSFQNSRHLESHQQTHMAKLSFECETCSKVFTSKTAIDYHKLNKHVPISEFKFTCTECSKKFLTERKLKNHMNSMHDPERIIICDKCGKQMRTKIILKKHQELMHSDTPRPEPELKQCQTCGAWLKGMTGLKQHMKSIHEESAGEHRCHVCSKVSPNARALRRHIYHNHECERKFKCTMCHKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILQQAVGATAAMKMQRIQHTSVASIESDLKHF