Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.1 2.8e+03 -1.9 0.1 29 48 156 176 142 200 0.73

2 2 6.1e-09 1.5e-05 24.6 0.0 7 58 267 309 261 330 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.1	2.8e+03	-1.9	0.1	29	48	156	176	142	200	0.73
2	2	6.1e-09	1.5e-05	24.6	0.0	7	58	267	309	261	330	0.81

Coding Sequence: ATGGCTGCCGCATCCGCTGgccaacagctgcagcagcagcagcagcaacaacagactCAGCACAAAGTGAacattgttggtgttggcaaTGCGGAGACGGTTGCTGGTGTGCTGCAGGTCAACAAtgagttgcaacagcaacagcaacagctcaaCATgtacaagcaacagcagcaacagcaattgttgcagcaacagcaacatcaattcTATCAGCAGCAAACGAAATTTGTATCGCGGGTCGTTACAAATGCAGCCGCaatgcaaccacaacaacaacaacagcagcaacaaatattaCCAGCTGGTTTGGTAAATGGCAGCGCCAACATGATGCAAGCCACAAATGTTGCtgtacagcagcagcagcaccaacaacagcagcagcagcaacaacaacagcagcagcaacaacaacaacagcagcaacaacaacagcagcaacaacaacaacaacaacaactgcgtcAAAGTCaacacatttttgtgtgtcCATCAATAGGCAcgcagctacagcaacagcaacaacagcagcagcagcaacttcaacagcagcagcagcaacttcaacagcagcagcagcaaagcaaacagcGTTTAGCGCAAATCAAGTTGCCTGTAAAgtccgcagcagcagcagcagtcggaACAGCAACTGTCTCTGCCGCTCACTGTatgccagcaacaattgcaatgcgTCAAATGAATCAGaaccatcagcaacagcaggtcTATGCTAAGAATgtggccaaaaacaataatgctggcaacaacatcaacatcaacagcaacagcagcaacaatgcaaatttgGCTCCAGGCTGGCGTCGactaaccaacaacaatgaagtGGCCTACATCAGTCCAACGGGCAAAACGCTGCGTACACAATTCCAAATTAAGGACTATTTGCTAACACAGGGTACCTGCAAGTGCGGCCTACCGTGTCCGCTGAGGCCGGAAtactttttcgattttaatgcACAGGTAAGTTAG
Protein Sequence: MAAASAGQQLQQQQQQQQTQHKVNIVGVGNAETVAGVLQVNNELQQQQQQLNMYKQQQQQQLLQQQQHQFYQQQTKFVSRVVTNAAAMQPQQQQQQQQILPAGLVNGSANMMQATNVAVQQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLRQSQHIFVCPSIGTQLQQQQQQQQQQLQQQQQQLQQQQQQSKQRLAQIKLPVKSAAAAAVGTATVSAAHCMPATIAMRQMNQNHQQQQVYAKNVAKNNNAGNNININSNSSNNANLAPGWRRLTNNNEVAYISPTGKTLRTQFQIKDYLLTQGTCKCGLPCPLRPEYFFDFNAQVS

Sequence clustering based on sequence similarity using MMseqs2