Basic Information

Gene Symbol
ZNF212
Assembly
GCA_037075245.1
Location
JBAMCH010000014.1:25256699-25258622[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 4.5 3.5e+02 2.1 0.0 3 16 29 42 27 44 0.83
2 11 1.2 96 3.9 4.4 1 20 113 132 113 133 0.92
3 11 0.0029 0.22 12.2 0.6 2 23 175 196 174 196 0.96
4 11 0.00022 0.017 15.7 0.9 1 23 222 243 222 243 0.98
5 11 0.0012 0.093 13.4 0.4 2 23 251 272 250 272 0.96
6 11 9.5e-05 0.0073 16.9 0.6 1 23 297 319 297 319 0.98
7 11 1.2e-07 9.4e-06 26.0 0.5 1 23 325 347 325 347 0.98
8 11 0.0011 0.082 13.5 5.5 1 23 353 375 353 375 0.98
9 11 4.1e-05 0.0032 18.0 0.2 1 23 381 403 381 403 0.97
10 11 1.4e-05 0.0011 19.5 0.3 1 23 407 429 407 429 0.99
11 11 0.0005 0.038 14.6 1.7 1 23 459 482 459 482 0.97

Sequence Information

Coding Sequence
ATGTCATTGTCCCACCAGAACGAGGAGAGTTGTACGGACGCCCACGTGGAGGATGCAGGTGCAGCGCCCCAGGAGTTCCTCTTTTGCGAGAACTGCGGCAACGTCTACGAGGACAGCGAGGCGTACGCCAGGGATCACAGCCAGTCCGGATCCTGTGGCGGCTCTAGCGAAGGATTGGAGTACGTAGACGAGACTGCACCAGACTACATTTTGGAGGAGGTCGGCGACGAGGATATTGTCGAGCCGGATGTGCCGCTCTGGGAGCTGGTGGAGGAAGTTCCGTCCCACATCAAggcggagcaggaggaggccGATGAGCCCAGCCAGTCGGACCGCTACTTTTGCTACGACTGCCACTGCATTTTCGAGAACCGCAGCAGCGCCGAGGAGCACGTTTGTCCGCGGGCGGAATCCGGCGCCGCTTCCAGCCACCAGGTCAATTTAGAGGCCAAAGCACCGGTCCGTCGAAAGCTGACCAGTGTTAGTGCGAGGACAGGACCAAAAGATGCTTCCTCCACAATTAGCTGCGGGATCTGCAACACCGTTTTCAGTTCGGACAAGTTCCTAAAGTTTCACATGCGCATCCACGAGAATCGCGCGTCCAAGAGCATTCAGGACGCCCTTCCTGTGGGCGCCCATCAGCAGTACAGCGAGCTGGATCAGTTCTACTGCGAAATCTGCAATAAGAGCTTCGATGAGAACCTCCTGACGGTGCATAAACAGATGCATCAGCAGTCAACCAACGAGATTATGTGCAGCATCTGCAACCGAAAGTTCGAAGATGACGTTACCTACCAGATGCACCAAAAAATCCACGAGAAGCCTCGCGAGCCTGACGCATCCAGCCGATTAAACCCGCGTCCTGGTGGCGACAAGGAGAAGACCGGTTTTCCCTGCCAGTACTGCGAGCGGGTGTTCACTCGGCCCTTCGAGAAGGTCAAGCACGAACGGGTCCACACCGGTGAGAAGCCCTACGCCTGCGAGGTCTGTGGGAAGACATTTCGCGTCTCCTATTCGCTGACCCTTCATCTGCGCACCCACACCAACATTCGACCGTATGTGTGCACGGTGTGCAACAAGCGcttTAAATCACACCAAGTGTACTCCCATCACCTGCGCATCCACAGTTCGGAGCGGCAGTTCGCCTGCGATGCGTGTCCCAAGGCGTTTCGCACCTCCGTGCAGCTGTACGCCCACAAGAACACCCACACCAAGCCGTACCAGTGCGCCGTGTGCAACCGGCCCTTCTCCTCGATGTACGCCGTCAAGAATCACATGCTCACGCACAAGGACGACAAGGGAAAGGGAAGTACTAGCGCTAGTACGCCGATCCCTAAGAATGGACAGCCGGTCAAGAGTCAGGCAGCTGCAAAATTCCATTGCAGTACTTGTGGAGCTGAGTATGCGCGTCTCTTCTCCCTGCGCCTGCACATGAAATCGAGCCACGGCGTCGTGGAGGATGGGACCTTGCCGCTGGAGGATCCCGCCGCCACAGCTGAAGAGGTGCAGGCCGCCGAGACCGATGACTCCGAGACAGCGGTGCTGATAGCTGCTGCCGAGGCAGATGCCGCTTATATTAACGCTGTGGTAAACGATGTCGACGTTGTGGGGTCTGTGCCCACCTACGAGGAGTGCGTAGAGTTCGATGTAGATAATTTCCACAGCGAGGAGATTATCACAGATTGGCTTAAGTag
Protein Sequence
MSLSHQNEESCTDAHVEDAGAAPQEFLFCENCGNVYEDSEAYARDHSQSGSCGGSSEGLEYVDETAPDYILEEVGDEDIVEPDVPLWELVEEVPSHIKAEQEEADEPSQSDRYFCYDCHCIFENRSSAEEHVCPRAESGAASSHQVNLEAKAPVRRKLTSVSARTGPKDASSTISCGICNTVFSSDKFLKFHMRIHENRASKSIQDALPVGAHQQYSELDQFYCEICNKSFDENLLTVHKQMHQQSTNEIMCSICNRKFEDDVTYQMHQKIHEKPREPDASSRLNPRPGGDKEKTGFPCQYCERVFTRPFEKVKHERVHTGEKPYACEVCGKTFRVSYSLTLHLRTHTNIRPYVCTVCNKRFKSHQVYSHHLRIHSSERQFACDACPKAFRTSVQLYAHKNTHTKPYQCAVCNRPFSSMYAVKNHMLTHKDDKGKGSTSASTPIPKNGQPVKSQAAAKFHCSTCGAEYARLFSLRLHMKSSHGVVEDGTLPLEDPAATAEEVQAAETDDSETAVLIAAAEADAAYINAVVNDVDVVGSVPTYEECVEFDVDNFHSEEIITDWLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
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