Basic Information

Insect: Drosophila meridionalis
Gene Symbol: zfh1
Assembly: GCA_035045145.1
Location: JAWNPG010000020.1:9649161-9653316[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4.8e-05 0.0034 17.8 1.7 1 23 150 172 150 172 0.97

2 15 0.00089 0.063 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9.7e-05 0.0068 16.9 0.1 1 23 373 395 373 395 0.98

4 15 0.012 0.87 10.3 0.9 1 23 401 423 401 423 0.98

5 15 3.7e-05 0.0026 18.2 2.2 1 23 454 477 454 477 0.95

6 15 0.00061 0.043 14.4 1.9 1 23 513 535 513 535 0.95

7 15 0.019 1.3 9.7 1.3 1 23 541 564 541 564 0.97

8 15 0.028 2 9.1 0.5 3 19 573 589 572 590 0.95

9 15 0.00017 0.012 16.1 5.6 1 23 599 621 599 621 0.97

10 15 0.044 3.1 8.5 1.2 2 23 627 648 626 648 0.96

11 15 9.9e-06 0.0007 20.0 1.0 1 23 657 679 657 679 0.98

12 15 0.00023 0.016 15.7 0.5 3 23 687 707 685 707 0.97

13 15 6e-05 0.0042 17.5 0.5 1 23 713 735 713 736 0.95

14 15 0.057 4 8.2 0.4 1 23 746 768 746 768 0.97

15 15 0.0006 0.043 14.4 0.5 1 23 1281 1303 1281 1303 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4.8e-05	0.0034	17.8	1.7	1	23	150	172	150	172	0.97
2	15	0.00089	0.063	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9.7e-05	0.0068	16.9	0.1	1	23	373	395	373	395	0.98
4	15	0.012	0.87	10.3	0.9	1	23	401	423	401	423	0.98
5	15	3.7e-05	0.0026	18.2	2.2	1	23	454	477	454	477	0.95
6	15	0.00061	0.043	14.4	1.9	1	23	513	535	513	535	0.95
7	15	0.019	1.3	9.7	1.3	1	23	541	564	541	564	0.97
8	15	0.028	2	9.1	0.5	3	19	573	589	572	590	0.95
9	15	0.00017	0.012	16.1	5.6	1	23	599	621	599	621	0.97
10	15	0.044	3.1	8.5	1.2	2	23	627	648	626	648	0.96
11	15	9.9e-06	0.0007	20.0	1.0	1	23	657	679	657	679	0.98
12	15	0.00023	0.016	15.7	0.5	3	23	687	707	685	707	0.97
13	15	6e-05	0.0042	17.5	0.5	1	23	713	735	713	736	0.95
14	15	0.057	4	8.2	0.4	1	23	746	768	746	768	0.97
15	15	0.0006	0.043	14.4	0.5	1	23	1281	1303	1281	1303	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAACAGCACGCATCCGCGGTGGACTCCGAGACCGACCTACTGGAAAACGGCGCTGCTGACAGCGAGGTAACGGCCGCCTACTTGGTCAATGGCAATGCAACCGACGAAGACCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCACGCGATGGTCAGCTGAGTGAGATTATTGCCGCCAACGAAAGCGGCGGCAGCACCGTTTTGATCACGGACAGCGGAACGGTTGCCTACGCCGAAGCATTTGACGATGATGCTGAGGTGGTCACCGAAGAGATCATCACGGATGACTGGGTGCAACATCAGGGCGCCGAGCGCGTGGAAATCGCTGCGGAACAGATTGCGGGCAATAACAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTACACGGCATTGCGACCCTATCCCTGTGACTTCTGCAGCCGGCGCTTCCGCAAGAAGACCAGCCTGAACAACCACATGCTGGCGCATCAGAACGATCGTCCGCACCTGTGTAAGTTGTGCGGCGCTCGGTTCTCGCGGCGGGCTGAGCTCATCAGTCACTTCAAGGCGCACGCCGAGGCACAGGATGCGGCCGATGCGGCGGCAGCAATCAAATTCGAgccgccacagcagcagcagcagcgccagatGGACGACCAGTTCTATGAGCAGGAGTGGTCTCTGTACCAGGAGCAGGAGGACGATGAAGTGCAACAAGATCTGCAGCAAATGGAAGAAGaccagcaggaggaggagcaggagcaggagctggaacagcaggagcaacagcagcatcaacatcacTTGGTGCTGCCGCAGGCTAGCTATGCTGCGATCAGTGATGTACCCGCTCCAACAGCCACGCGCGGTCGCATTAGCCGCCTCAAGCCCAAGGAGGAGTGCACTCAGTACATTGTGATTCCCGAGAAGCAGACAACGGATGACTTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGCCAACGCTGACCAGCGGCACGCCAATCGAAGCGGCCCAAGTGGCGGTCAGCGTGCCCGTTGCCGAGACGGCTCAGGCTCAACGCTTTCCGGTGATAGACGACAGTAAACCCTTTGTGTGCCAGCAATGCGGCTTGGCATTTGCGCGCGAGAAGGCGCTGGTCTCGCATATTAAGAATCATCGAGTTGACTCTCCGTTCGAATGCAATCAGTGCCAGGACATGTTCTGGGACAACTACAGCCTGCAGGAGCACCAGAAGACCCATCAGTTCGAGGAGAGCAATTCGGAGTACGATCCGGCCTCGGCTGGAGAAGACAGCGCCAGCGAGTCGGAGCCGGAGCAGCTGTACGGCGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGATCTGCTGCGTCGCCATgcgaagcagcagcacaagcagCTGACCACGGACGCAGAGGGCGTCGCTGgcgatgcggatgcggatgcggatgcggatgcggatgcggatgcggatgccgAGAATGCCAAAGATGCGCAGCATTGCTGTCACACGTGTGGCAAATCCTTTCCCAGCGCCTTGGAGCTGCTCGCCCATGCCGAAGTGCATGCGCGCTTCCCGCCCTTCAAATGCGTTCTGTGTGGCGTTAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATCTGCACACGCGCCACCCGCACGAGCTGAGGCCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGTCGCGATCGCAAGGCCCTGATGAAGCACGCCTGGGATCACTCGCGGGAGAAGTGCCACTCGTGCTCGAAGTGCGGCAAGAACTTCCACAACAAGGCGCGACTGAAGCGGCACATGGCCTCGCATCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAGGAGTTCCCCGACGGACGCACGCTGTCCAATCATCGGCACTCGCACAGCACCACCTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATACATGTGCGCATCCATACGGGCGAGCGACCCTATGGCTGTCACTACTGCTGGAAGGCGTTCGCGGATGGGGGAACGCTGCGCAAGCACGAGCGCATCCACACCGGCGAGAAGCCCTACGCCTGCTCCGTGTGTCCACGCGCCTTCAACCAGCGCGTCGTGCTGCGCGAGCACATACGCTCGCATCACTCGGGTCTGGATGCTGTGCGAGGAACCTACCACTGCACCGTCTGTTCGGCCGACTTGTCGTCGTCCAATGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACAGCCAAGCAGCGACAGCCAATCACTGGTCCGCGGAAGTACAAGCGACGCAGGAAACTGCAACCACATGAGATCGCCCACATGCGAGCGGAGCACAAGGATGGCGAGGATTATGGCAGCGACATGGACTTCTGTGACTTGGATGTGGAGAATGTGGACGATCTTCTCGAGGGGTCGGACACGTTGCCAGCCAAAAAGGAGAAGCGCAAGCGTACGGCTGCCAGCCAGGCCAAGGCCGTGTCGAACGGGGGCTCAAGTAGCAACGCCTCCGCTTCGGCTAAGTccgctgcagctggcagctgggaTGAGAAGTTCCTGCAGACGaatagcaacggcaacgggGCCAACGCTGATGAGAGCTTCTACCAGATTGATTCGCTCGTGGTGGTCAACGATACGACGCTGCCGGCCGTTAGCCCTTCCAGCAATGCGCAAGGTGCCTCCAAATCGCGGCGAGGCGGGGCCAAGCAGACGGAGAATGGTGCCAAATCGGGAGGAGCTGCAGAGTCCGGCAAATCCAGCGTGgccagcagtcgcagcagcagccgcaagaaGTCGAGCAGGTCGGCCAAGAGTGCAcccacagcagctgcagcagcaaccgcagccaGCACGACGAGCAGCTCGCGTCCACGCATGATACACACGGAGAAGTCGCGTGTGCCGCCAGAGAATGCATCGAAGAGGTCGCGTGGGCGCAGCTACATTACGCGCACCAGCACCAGCGAGGCCAGCAGCCAGCTGAGCAGTCAGCTGGCCAAGGCGAGCGGCGTCTCTAGTTCGCGGATTGTCGACGACTACGAGATCATATCACCCGCCACCCAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcagcagcagcgcgtcCAGTTCATGTACGACGACACCCATCTGATGATCCATTCGGGCATGTTGCGGGAGAAGCCCTACGACAAGTTCAATCCGAGTATTGTCAATGATCTCGAGGAGATTTTGCGCAGTCCGCTCAAGCACGATCGGAATGCGCGGCTGCGTTTCACCAGCGAATCGTCGACGACGCCACAGTTCCTGCCAGAGGAGGAGCAAAATCTGATCAAGATTGAGCCCACGTCGCCGGATCTGCGCGACATGGTGGAGAGCCAGCAGCGTGTCAACTCCACAAGAGCACaggcggccacgcccacatcgtCGGCGGCGCGCACATCGCGCCACCTGCGACAGCTCACTGGGAACAGTTCGGGCAGCCGAACGGCGTCCAAGCGAAGCTCTGGCAAATCCTCAGCTGCCGGCGGCTTCAGCGCCACGAagtccagcagcaacacatcCTCATCGGAAGCTGTCAGCAAGTCGTACCTCAGCTACGGCGTGGACTCCTACAATGTGAACGTGGTAGCGAGCGCCAACTCTTCGGATGTCAGTTCCGGTTTCTTCTCCATCTCCGAGGTGGTCTCCGCCGCCCACGCAGCCGACGCAGCCAAAGCAGCAGCCGCGAGCAAAACGGAGCGCCGGACCCGGTGCTTCGAGTGCGAGATGTGCTCCTCCATATTCTCCGACCGggcgcagctgctggagcacatgcacatacacatctAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGSTVLITDSGTVAYAEAFDDDAEVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKTSLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAAAAIKFEPPQQQQQRQMDDQFYEQEWSLYQEQEDDEVQQDLQQMEEDQQEEEQEQELEQQEQQQHQHHLVLPQASYAAISDVPAPTATRGRISRLKPKEECTQYIVIPEKQTTDDLQQYMECEELPPTLTSGTPIEAAQVAVSVPVAETAQAQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQLTTDAEGVAGDADADADADADADADAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELRPNSCVLCGKECRDRKALMKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYGSDMDFCDLDVENVDDLLEGSDTLPAKKEKRKRTAASQAKAVSNGGSSSNASASAKSAAAGSWDEKFLQTNSNGNGANADESFYQIDSLVVVNDTTLPAVSPSSNAQGASKSRRGGAKQTENGAKSGGAAESGKSSVASSRSSSRKKSSRSAKSAPTAAAAATAASTTSSSRPRMIHTEKSRVPPENASKRSRGRSYITRTSTSEASSQLSSQLAKASGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDTHLMIHSGMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVNSTRAQAATPTSSAARTSRHLRQLTGNSSGSRTASKRSSGKSSAAGGFSATKSSSNTSSSEAVSKSYLSYGVDSYNVNVVASANSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00544633;
80% Identity: -