Basic Information

Insect: Drosophila meridiana
Gene Symbol: zfh1
Assembly: GCA_035045185.1
Location: JAWNPF010000055.1:24406187-24410321[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4.8e-05 0.0036 17.9 1.7 1 23 150 172 150 172 0.97

2 15 0.00088 0.066 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9.6e-05 0.0072 16.9 0.1 1 23 373 395 373 395 0.98

4 15 0.012 0.92 10.3 0.9 1 23 401 423 401 423 0.98

5 15 3.6e-05 0.0027 18.2 2.2 1 23 454 477 454 477 0.95

6 15 0.0006 0.045 14.4 1.9 1 23 505 527 505 527 0.95

7 15 0.019 1.4 9.7 1.3 1 23 533 556 533 556 0.97

8 15 0.028 2.1 9.1 0.5 3 19 565 581 564 582 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 591 613 591 613 0.97

10 15 0.043 3.3 8.5 1.2 2 23 619 640 618 640 0.96

11 15 9.7e-06 0.00073 20.0 1.0 1 23 649 671 649 671 0.98

12 15 0.00023 0.017 15.7 0.5 3 23 679 699 677 699 0.97

13 15 5.9e-05 0.0044 17.6 0.5 1 23 705 727 705 728 0.95

14 15 0.056 4.2 8.2 0.4 1 23 738 760 738 760 0.97

15 15 0.0006 0.045 14.4 0.5 1 23 1273 1295 1273 1295 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4.8e-05	0.0036	17.9	1.7	1	23	150	172	150	172	0.97
2	15	0.00088	0.066	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9.6e-05	0.0072	16.9	0.1	1	23	373	395	373	395	0.98
4	15	0.012	0.92	10.3	0.9	1	23	401	423	401	423	0.98
5	15	3.6e-05	0.0027	18.2	2.2	1	23	454	477	454	477	0.95
6	15	0.0006	0.045	14.4	1.9	1	23	505	527	505	527	0.95
7	15	0.019	1.4	9.7	1.3	1	23	533	556	533	556	0.97
8	15	0.028	2.1	9.1	0.5	3	19	565	581	564	582	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	591	613	591	613	0.97
10	15	0.043	3.3	8.5	1.2	2	23	619	640	618	640	0.96
11	15	9.7e-06	0.00073	20.0	1.0	1	23	649	671	649	671	0.98
12	15	0.00023	0.017	15.7	0.5	3	23	679	699	677	699	0.97
13	15	5.9e-05	0.0044	17.6	0.5	1	23	705	727	705	728	0.95
14	15	0.056	4.2	8.2	0.4	1	23	738	760	738	760	0.97
15	15	0.0006	0.045	14.4	0.5	1	23	1273	1295	1273	1295	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTGGACTCCGAGACCGACCTACTGGAAAACGGCGCTGCTGACAGCGAGGTAACGGCCGCCTACTTGGTCAATGGCAATGCAACCGACGAAGACCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCACGCGATGGTCAGCTGAGTGAGATTATTGCCGCCAACGAAAGCGGCGGCAGCACCGTTTTGATCACGGACAGTGGAACGGTTGCCTACGCCGAAGCATTTGACGAGGATGCTCAGGTGGTCACCGAGGAGATCATCACGGATGACTGGGTGCAACATCAGGGCGCCGAGCGCGTGGAAATCGCTGCGGAACAAATTGCGGGCAATAACAGCTCACAGGAGCTGCTGGACATGGAGCAGGACGAGTACACGGCATTGCGACCCTATCCCTGTGACTTCTGCAGCCGACGCTTCCGCAAGAAGACCAGCCTGAACAACCACATGCTGGCACATCAGAACGATCGTCCGCACCTGTGTAAGTTGTGCGGCGCTCGGTTCTCGCGGCGGGCTGAGCTCATCAGTCACTTCAAGGCGCACGCCGAGGCACAGGATGCGGCCGATGCGGCGGCAGCAATCAAATTCGAgccgccacagcagcagcagcagcgccagatGGACGACCAGTTCTATGAGCAGGAGTGGTCTCTGTaccaggagcaggaggacGATGAAGTGCAACAAGATCTGCAGCAAATGGAAGAAGaccagcaggaggaggagcaggagcaggagctggaacagcaggaacaacagcagcatcaacatcaCTTGGTGCTGCCGCAGGCTAGCTATGCTGCGATCAGTGATGTACCCGCTCCAACAGCCACGCGCGGTCGCATTAGTCGCCTCAAGCCCAAGGAGGAGTGCACTCAGTACATTGTGATTCCCGAGAAGCAGACAACGGATGACTTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGCCAACGCTGACCAGCGGCACGCCAATCGAAGCGGCCCAAGTGGCGGTCAGCGTGCCCGTTGCCGAGACGGCTCAGGCTCAACGTTTTCCGGTGATAGACGACAGCAAACCCTTTGTGTGCCAGCAGTGCGGCTTGGCATTTGCGCGCGAGAAGGCGCTGGTCTCGCATATTAAGAATCATCGAGTTGACTCTCCGTTCGAATGCAATCAGTGCCAGGACATGTTCTGGGACAACTACAGCCTGCAGGAGCACCAGAAGACCCATCAGTTCGAGGAGAGCAATTCGGAGTACGATCCGGCCTCGGCTGGGGAGGACAGCGCCAGCGAGTCGGAGCCGGAGCAGCTGTACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGATCTGCTGCGTCGCCATgcgaagcagcagcacaagcagCTGACCACGGACGTGGAGGGCGTCGCTGgcgatgcggatgcggatgcggatgccgAGAATGCCAAAGATGCGCAGCATTGCTGTCACACGTGTGGCAAATCCTTTCCCAGCGCCTTGGAGCTGCTCGCCCATGCCGAAGTGCATGCGCGCTTCCCGCCCTTCAAATGCGTTCTGTGTGGCGTTAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATCTGCACACGCGCCACCCGCACGAGCTGAGGCCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGTCGCGATCgcaaggccctgatgaagcaCGCCTGGGATCACTCGCGGGAGAAGTGCCACTCGTGCTCAAAGTGCGGCAAGAACTTCCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAGGAGTTCCCCGACGGACGCACGCTGTCCAATCATCGGCACTCGCACAGCACCACGTCGGCGGGCAAACTCTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATACATGTGCGCATCCATACGGGCGAGCGACCCTATGGCTGTCACTATTGCTGGAAGGCGTTCGCGGATGGGGGAACGCTGCGCAAGCACGAGCGCATCCACACGGGCGAGAAGCCCTACGCCTGTTCCGTGTGTCCACGCGCCTTTAACCAGCGCGTCGTGCTGCGCGAGCACATACGCTCGCATCATTCGGGTCTGGATGCTGTGCGAGGAACCTACCACTGCACCGTCTGCTCGGCGGACTTGTCCTCGTCCAACGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACAGCCAAGCAGCGACAGCCAATCACTGGTCCGCGGAAGTACAAGCGACGCAGGAAACTGCAGCCACATGAGATCGCCCACATGCGAGCGGAGCACAAGGATGGCGAGGATTATGGTAGCGACATGGACTTCTGTGACTTGGATGTGGAGAATGTGGACGATCTTCTCGAGGGGTCGGACACGTTGCCAGCCAAAAAGGAGAAGCGCAAGCGTACGGCTGCCAGCCAGGCCAAGGCCGTGACGAACGGGGGATCAAGTAGCAACGCCTCCGCTTCGGCTAAGTCCGccgcagctggcagctgggaTGAGAAGTTCCTGCAGACGaatagcaacggcaacgggGCCAACGCTGATGAGAGCTTCTACCAGATTGATTCGCTCGTGGTGGTCAACGATACGACGCTGCCGGCCGTTAGCCCCTCCAGCAATGCGCAAGGTGCTTCCAAATCGCGGCGAGGCGGGGCCAAGCAGACGGAGAATGGTGCCAAATCGGGAGGAGCTGCAGAGTCCGGCAAATCCAGTGTCgccagcagtcgcagcagcagccgcaagaaGTCGAGCAGGTCGGCCAAGAGTGCacccacagcagctgcagcagcaaccgcagccaGCACGACGAGCAGCTCGCGTCCACGCATGATACACACGGAGAAGTCGCGTGTGCCGCCAGAGAATGCATCGAAGAGGTCGCGTGGGCGCAGCTATATTACGCGCACCAGCACCAGCGAGGCCAGCAGCCAGCTGAGCAGTCAGCTGGTCAAGGCGAGCGGCGTCTCCAGTTCGCGGATTGTCGATGACTACGAGATCATATCACCCGCCACCCAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcagcagcagcgcgtcCAGTTCATGTACGACGACACCCATCTGATGATCCATTCGGGCATGTTGCGGGAGAAGCCCTACGACAAGTTCAATCCGAGTATTGTCAATGATCTCGAGGAGATTTTGCGCAGTCCGCTCAAGCACGATCGGAATGCGCGCCTGCGCTTCACTAGCGAATCGTCGACGACGCCACAGTTCCTGCCAGAGGAGGAGCAAAATCTGATCAAGATTGAGCCCACGTCGCCGGATCTGCGCGACATGGTGGAGAGCCAGCAGCGTGTCAACTCCACAAGAGCACaggcggccacgcccacatcgtCGGCGGCGCGCACATCGCGCCACCTGCGACAGCTCACTGGGAACAGTTCGGGCAGCCGAACGGCGTCCAAGCGAAGCTCTGGCAAATCCTCAGCTGCCGGCGGCTCCAGCGCCACGAagtccagcagcaacacatcCTCATCGGAAGCTGTCAGCAAGTCGTACCTCAGCTACGGCGTGGACTCCTACAATGTGAGCGTGGCAGCGAGCGCCAACTCGTCGGATGTCAGTTCCGGTTTCTTCTCCATCTCCGAGGTGGTCTCCGCCGCCCACGCAGCCGACGCAGCCAAAGCAGCAGCCGCGAGCAAAACGGAGCGCCGGACCCGCTGCTTCGAGTGCGAGATGTGCTCCTCCATATTCTCCGACCGGGCGCAGCTGCTGGagcacatgcacatacacatcTAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGSTVLITDSGTVAYAEAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKTSLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAAAAIKFEPPQQQQQRQMDDQFYEQEWSLYQEQEDDEVQQDLQQMEEDQQEEEQEQELEQQEQQQHQHHLVLPQASYAAISDVPAPTATRGRISRLKPKEECTQYIVIPEKQTTDDLQQYMECEELPPTLTSGTPIEAAQVAVSVPVAETAQAQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKQLTTDVEGVAGDADADADAENAKDAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELRPNSCVLCGKECRDRKALMKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSAGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKDGEDYGSDMDFCDLDVENVDDLLEGSDTLPAKKEKRKRTAASQAKAVTNGGSSSNASASAKSAAAGSWDEKFLQTNSNGNGANADESFYQIDSLVVVNDTTLPAVSPSSNAQGASKSRRGGAKQTENGAKSGGAAESGKSSVASSRSSSRKKSSRSAKSAPTAAAAATAASTTSSSRPRMIHTEKSRVPPENASKRSRGRSYITRTSTSEASSQLSSQLVKASGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDTHLMIHSGMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESQQRVNSTRAQAATPTSSAARTSRHLRQLTGNSSGSRTASKRSSGKSSAAGGSSATKSSSNTSSSEAVSKSYLSYGVDSYNVSVAASANSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00545385;
80% Identity: -